Clinical trials: Pneumocystis Jirovecii
Chronic Obstructive Pulmonary Disease (COPD)
Study on the Impact of Decolonization Treatment of Pneumocystis Jirovecii on the Frequency of Acute Exacerbation in COPD
Previous researches have found the common colonization of Pneumocystis jirovecii (Pj) in the airways of people with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07665359
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Where
- 20 sites in China
- Volunteers
- 630 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bronchoalveolar Lavage Fluid, Lung Infection
Diagnosis of Lung Complication After Allo-HSCT by Multiple Parameter System Through BAL
The aim of this study was to evaluate the diagnostic yield for lung complication after allo-HSCT by multiple parameter system through BAL.
- Trial name
- SHSYXY-BAL (NCT04051372)
- Testing
- Bronchoscopic Alveolar Lavage
- Volunteers
- 250 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Idiopathic Pulmonary Fibrosis
Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole
First study to test the validity of the treatment of idiopathic pulmonary fibrosis, which causes inflammation and fibrosis (scarring) of the lung tissue, with cotrimoxazole.
- Trial name
- TriSulfa-FPI (NCT01777737)
- Testing
- Cotrimoxazole
- Where
- Spain
- Volunteers
- 3 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pneumocystis Jirovecii Pneumonia, Kidney Transplantation
Low- vs Standard-Dose TMP-SMX for Prevention of Pneumocystis Pneumonia After Kidney Transplantation
This study is a prospective randomized controlled trial designed to evaluate the efficacy and safety of low-dose versus standard-dose trimethoprim-sulfamethoxazole (TMP-SMX) for the prevention of Pneumocystis jirovecii pneumonia…
- Trial name
- TMP-SMX PJP (NCT07619027)
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Volunteers
- 1,084 people
- Sponsor
- Anhui Provincial Hospital
Pneumocystis, Pneumocystis Infection
Positioning Second-line Therapies for Pneumocystis Jirovecii Pneumonia (PCP Alternatives)
The usual first treatment for Pneumocystis jirovecii pneumonia (PCP) is an antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX).
- Conditions
- Pneumocystis, Pneumocystis Infection, Pneumocystis Carinii Infection, Pneumocystis Carinii; Infection, Resulting From HIV Disease
- Trial name
- SPIRIT-ALT (NCT07357103)
- Testing
- Clindamycin + primaquine, Pentamidine, Atovaquone
- Volunteers
- 416 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pneumocystis Jirovecii Pneumonia
Radiomics Model for the Diagnosis of Pneumocystis Jirovecii Pneumonia in Non-HIV Patients
To evaluate the performance of radiomics in differentiating Pneumocystis jirovecii pneumonia (PCP) from other types of pneumonia and to improve the diagnostic efficacy of non-invasive tests in non-HIV patients.
- Trial name
- NCT05701631
- Testing
- Radiomic model
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Chinese PLA General Hospital
Pneumonia, Pneumocystis, Autoimmune Inflammatory Rheumatic Disease
Efficacy and Safety of Prophylactic Treatment for Pneumocystis Jirovecii Pneumonia in Patients With Autoimmune Inflammatory Rheumatic Disease
This is an open-labeled, prospective clinical study aims at collecting and analyzing baseline characteristics of autoimmune inflammatory rheumatic disease (AIIRD) patients receiving sulfanilamide for preventive purposes, as well…
- Conditions
- Pneumonia, Pneumocystis, Autoimmune Inflammatory Rheumatic Disease, Autoimmune Diseases, Connective Tissue Disease
- Trial name
- NCT06499233
- Testing
- Trimethoprim/Sulfamethoxazole
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Tongji Hospital
Pneumonia, Pneumocystis
Specialized Proresolving Mediators in Pneumocystis Jirovecii Pneumonia
This study aims to evaluate specialized proresolving mediators (SPM) concentrations for the first time in subjects infected with Pneumocystis jirovecii.
- Trial name
- INFLA-PCP (NCT03606252)
- Testing
- Blood sampling, urine sampling
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Toulouse
Pneumocystis Jirovecii Infection
Pneumocystis Jirovecii Pneumonia in Non-HIV-infected Immunocompromised Patients
Pneumocystis jirovecii pneumonia (PjP) is a rare infectiouse disease with a high level of mortality. PjP is a classical opportunistic infection which concern HIV infected and immunocompromised patients.
- Trial name
- PnP-HIV-Free (NCT05458752)
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Central Hospital, Nancy, France
HIV-1-infection, Pneumocystis Pneumonia
Caspofungin for Pneumocystis Pneumonia in PLWHIV.
Pneumocystis jirovecii pneumonia is a significant concern in peaple with HIV/AIDS, often severe and potentially fatal. While trimethoprim/sulfamethoxazole remains the primary treatment, safety concerns exist with alternative…
- Trial name
- NCT06691321
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Pneumocystis Jirovecii Pneumonia
A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy
In this study, we aim to investigate the incidence of the adverse reactions, the effectiveness and the gene polymorphism associated with the plasma level of sulfamethoxazole-trimethoprim and their metabolites (including…
- Trial name
- NCT02045160
- Where
- 2 sites in Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Non-HIV Patients With Pneumocystis Jiroveci Pneumonia
Assessment of CMV-specific ELISPOT Assay for Predicting CMV Co-infection in Patients With Pneumocystitis Pneumonia (ACE-PCP)
PCP (Pneumocystis jiroveci pneumonia) is one of the important opportunistic infections in immunocompromised patients including HIV-infected patients, transplant recipients, and immunosuppressant users.
- Trial name
- NCT02109887
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
COPD Exacerbation Acute
Treatment of Pneumocystis in COPD (the TOPIC Study)
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease associated with chronic inflammation in the airways and lung, resulting in significant morbidity and mortality worldwide.
- Trial name
- NCT05418777
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Corewell Health East
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Pneumocystis Jiroveci Pneumonia, Intensive Care Unit
Prospective Registration of Severe Pneumocystis Jiroveci Pneumonia Requiring ICU Admission
the investigators aim to set up a multicenter registry study for severe PJP requiring ICU admission. The purpose of this study is 1.
- Trial name
- NCT03201497
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Pneumocystis Jirovecii Pneumonia in Non-HIV Patients
TMP-SMX for Non-HIV PCP: A Prospective Multicenter Study
Pneumocystis jirovecii pneumonia (PCP) is a life-threatening opportunistic infection in immunocompromised patients. Non-HIV-related PCP has a rising incidence, faster progression, and higher mortality than HIV-associated cases.
- Trial name
- NCT07690410
- Testing
- low-dose TMP-SMX regimen
- Volunteers
- 480 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pneumocystis Pneumonia
Rezafungin for Treatment of Pneumocystis Pneumonia in HIV Adults
This study aims to generate clinical data on the efficacy, safety, and tolerability of rezafungin combined with 7 days of co-trimoxazole for treatment of Pneumocystis pneumonia (PCP) in adults living with human immunodeficiency…
- Trial name
- NCT05835479
- Testing
- Co-Trimoxazole, Rezafungin Acetate / Co Trimoxazole
- Where
- 6 sites in South Africa
- Volunteers
- 50 people
- Sponsor
- Mundipharma Research Limited
Pulmonary Nodule, Invasive Fungal Infections
Granulomatous Pneumocystis Pneumonia
The intra-alveolar form of Pneumocystis jiroveci pneumonia (PjP) is a common pathology in immunocompromised patients, particularly those infected with HIV. The diagnosis is based on the detection of Pj in a LBA.
- Conditions
- Pulmonary Nodule, Invasive Fungal Infections, Pneumocystis Jirovecii
- Trial name
- NC (NCT03731156)
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pneumocystis Jirovecii Infection, Pneumocystis
Prospective Observational Study on the Incidence of Opportunistic Fungal Infections
Corticosteroids exposure is a common risk factor for invasive fungal infections. Systemic corticosteroid therapy treats several medical conditions, including rejection in solid organ transplant recipients, malignancy, and…
- Conditions
- Pneumocystis Jirovecii Infection, Pneumocystis, Cryptococcosis, Candidiasis
- Trial name
- NCT05707156
- Where
- United States
- Volunteers
- 12,032 people
- Sponsor
- University of Colorado, Denver
Pneumocystis, Pneumocystis Pneumonia
Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia
Pneumocystis jirovecii pneumonia (PCP) is an opportunistic fungal infection of immunocompromised hosts which causes in significant morbidity and mortality.
- Conditions
- Pneumocystis, Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- LOW-DOSE (NCT04851015)
- Testing
- trimethoprim-sulfamethoxazole
- Where
- Canada
- Volunteers
- 416 people
- Sponsor
- Todd C. Lee MD MPH FIDSA