Clinical trials: Pneumonia, Hospital-Acquired
Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
This was a Phase 3 study containing a randomized open-label superiority cohort (Cohort 1) comparing the efficacy and safety of plazomicin with colistin when combined with a second antibiotic (either meropenem or tigecycline) in…
- Conditions
- Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE, Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE, Complicated Urinary Tract Infection (cUTI) Due to CRE
- Trial name
- CARE (NCT01970371)
- Testing
- plazomicin, colistin, meropenem
- Volunteers
- 69 people
- Sponsor
- Achaogen, Inc.
Head and Neck Cancer, Tracheostomy Complication
Hospital Acquired Pneumonia in Temporary Tracheostomy
Medical condition or disease under investigation: Oromaxillofacial surgery in head and neck cancer Purpose of research: Retrospective data analysis identifying hospital acquired pneumonia in patients who undergo temporary…
- Conditions
- Head and Neck Cancer, Tracheostomy Complication, Hospital-acquired Pneumonia, Surgery
- Trial name
- HAP (NCT05418517)
- Testing
- Tracheostomy, Overnight intubation
- Where
- United Kingdom
- Volunteers
- 193 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Bacterial Pneumonia
Assessment of the Diagnostic Capacity of the Mini-broncho Alveolar Lavage Performed Through a Suction Catheter
The aim of this study is to develop a safe and effective technique to take sample for lower respiratory tract cultures easy to perform in conditions of acute respiratory failure and spontaneous ventilation for patients admitted…
- Trial name
- Mini-LBA (NCT00763620)
- Testing
- catheter for mini bronchoalveolar lavage
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Coronary Artery Disease, Pneumonia Nosocomial
Nosocomial Pneumonia After Coronary Artery Bypass Grafting
Observational studies of patients with coronary artery bypass grafting, associated with an unfavorable cardiopulmonary prognosis for at least one year after surgery.
- Trial name
- CABG-PNEUM (NCT07476274)
- Testing
- Clinical, laboratory, and instrumental examination
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Covid19, Muscle Atrophy
Electrical Stimulation for Critically Ill Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- Covid19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase I (NCT04685213)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Community-Acquired Infections, Pneumonia
Community-acquired Pneumonia in Buskerud County in Norway
The purpose of this study is to determine the etiology of community-acquired pneumonia, to assess risk factors and to investigate potential prognostic biomarkers of serious disease and fatal outcome.
- Trial name
- NCT01563315
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- Vestre Viken Hospital Trust
Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia
Imipenem/Cilastatin-XNW4107 Versus Imipenem/Cilastatin/Relebactam for Treatment of Participants With Bacterial Pneumonia (XNW4107-302, REITAB-2)
This study aims to compare treatment with Imipenem/Cilastatin-XNW4107 (IMI-XNW4107) with imipenem/cilastatin/relebactam (IMI/REL) in participants with hospital-acquired or ventilator-associated bacterial pneumonia (HABP or VAPB…
- Trial name
- REITAB-2 (NCT05204563)
- Testing
- Combination of Imipenem/Cilastatin and XNW4107, Imipenem/Cilastatin/Relebactam
- Where
- 35 sites in United States, France and 2 more
- Volunteers
- 450 people
- Sponsor
- Evopoint Biosciences Inc.
HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
Multicenter, randomized, controlled, open-label trial to assess if semiquantitative multiplex PCR assay, as compared to conventional microbiology, can reduce the percentage of patients without microbiological diagnosis in the…
- Trial name
- LIGHTNING (NCT05952648)
- Testing
- Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture
- Where
- 4 sites in Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID 19
Prospective Hospital Registry of Patients With Suspected or Confirmed Coronavirus Infection (COVID-19) and Community-acquired Pneumonia
Coronavirus-2019 disease (COVID-19) and community-acquired pneumonia are significant problems of modern medicine. Pneumonia is the most common severe complication of COVID-19.
- Trial name
- TARGET-VIP (NCT04522076)
- Where
- 2 sites in Russia
- Volunteers
- 1,130 people
- Sponsor
- National Research Center for Preventive Medicine
Community Acquired Pneumonia, Hospital Acquired Pneumonia
HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract Infections
HOME FIRST (Home Followed - up with Infection Respiratory Support Team) is an early supported discharge scheme. It will enable patients with lower respiratory tract infection (LRTI) to be provided with high quality safe…
- Conditions
- Community Acquired Pneumonia, Hospital Acquired Pneumonia, Lower Respiratory Tract Infection
- Trial name
- HOMEFIRST (NCT02454114)
- Testing
- HOMEFIRST, Standard Hospital Care
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Ventilator-Associated Pneumonia, Nosocomial Pneumonia
Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia
Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection.The possible association between oral care and incidence of VAP, and the role of dental plaque, mouth and tracheal colonization…
- Conditions
- Ventilator-Associated Pneumonia, Nosocomial Pneumonia, Pneumonia
- Trial name
- RASPALL (NCT00842478)
- Testing
- Toothbrushing
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Pneumonia
An Open-label, Randomized, and Comparative Study to Evaluate the Efficacy and Safety of Cefoperazone/Sulbactam in Comparison to Cefepime for the Treatment of Hospital-acquired Pneumonia and Healthcare-associated Pneumonia
This is a phase III, multi-center, open-label, comparative and randomized study in evaluating the efficacy and safety of cefoperazone/sulbactam versus cefepime for the treatment of hospital-acquired pneumonia and…
- Trial name
- NCT01280461
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- Taipei Medical University WanFang Hospital
Pneumonia, Mortality
Lactate Clearance in Hospital-acquired Pneumonia
There is no clear consensus on the use of pneumonia severity index (PSI) developed for community-acquired pneumonia in hospital-acquired pneumonia cases.
- Conditions
- Pneumonia, Mortality, Lactate, Prognosis
- Trial name
- NCT04826848
- Testing
- Lactate
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Ankara City Hospital Bilkent
COVID-19, Muscle Atrophy
Electrical Stimulation for Critically Ill Post-Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- COVID-19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase II (NCT05198466)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Community Acquired Pneumonia, Hospital Acquired Pneumonia
The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia
The purpose of the study is to determine if the clinical course of pneumonia is more severe when both, bacterial and viral pathogens are find as possible causative agent and how does it affect treatment.
- Conditions
- Community Acquired Pneumonia, Hospital Acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- SCAHAVAP (NCT02203110)
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Covid19, Ventilator Associated Pneumonia
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:
A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation.
- Conditions
- Covid19, Ventilator Associated Pneumonia, Nosocomial Pneumonia
- Trial name
- COVAP (NCT04488510)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Mechanical Ventilation Complication, Tracheal Intubation Morbidity
Continuous Endotracheal Cuff Pressure Control to Prevent Ventilator Associated Respiratory Infections
The purpose of the study is to determine whether automated cuff pressure control results in a reduction in the proportion of patients developing ventilator associated respiratory infections during their stay in intensive care.
- Conditions
- Mechanical Ventilation Complication, Tracheal Intubation Morbidity, Ventilator-Associated Pneumonia, Hospital Acquired Infection
- Trial name
- VARI-prevent (NCT02966392)
- Testing
- Tracoe cuff pressure controller
- Where
- 3 sites in Vietnam
- Volunteers
- 600 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Community Acquired Bacterial Pneumonia
Use of Ceftaroline in Hospitalized Patients With Community Acquired Pneumonia
Community-acquired bacterial pneumonia, which is often called CAP, is a bacterial infection in the lungs and is treated with antibiotics. Sometimes people need to be in the hospital to be treated for CAP.
- Trial name
- CAP (NCT01605864)
- Testing
- Efficacy of ceftaroline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albany Medical College
Hospital-acquired Pneumonia
Efficacy and Safety of Colistimethate Sodium Injection Vial to Treat Hospital-acquired Pneumonia in Adults
1. To evaluate the clinical and microbiological efficacy and safety of Colistimethate sodium Injection Vial to treat adults with hospital-acquired pneumonia . 2.
- Trial name
- NCT01940731
- Testing
- Colistimethate sodium
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.