Clinical trials: Pneumonia; Pulmonary Infection
COVID-19 Pneumonia, Sepsis
Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia
The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome…
- Conditions
- COVID-19 Pneumonia, Sepsis, SARS-CoV-2 Acute Respiratory Disease, Pneumonia
- Trial name
- RANCH-COVID (NCT05181696)
- Testing
- Chest X-ray
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Osijek University Hospital
COVID-19
The LUSZ COVID-19 Severity Index: A Prognostic and Predictive Score of Mortality for Hospitalized Patients With Covid-19
The coronavirus disease 2019 (COVID-19) has spread rapidly and caused a global pandemic, as defined by the WHO, within a short period of time.
- Trial name
- LUSZ_SCORE (NCT05848427)
- Testing
- LUSZ P
- Where
- 2 sites in Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Lebanese University
Covid19, Burnout, Professional
Burnout, Stress and Coping Strategies: Impact of the Covid-19 Epidemic
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus detected in Wuhan, China on December 2019. This virus is responsible for the infectious respiratory disease called Covid-19.
- Trial name
- Au20-15 (NCT04834882)
- Testing
- Data collection (
- Where
- France
- Volunteers
- 649 people
- Sponsor
- CHU de Reims
Severe Acute Respiratory Syndrome Coronavirus 2, Hypoxemic Respiratory Failure
COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia
The purpose of the COVIDNOCHE trial (HFNO versus CPAP Helmet Evaluation in COVID-19 Pneumonia) is to evaluate the comparative effectiveness of standard care non-invasive respiratory support (helmet CPAP versus HFNO) for acute…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Hypoxemic Respiratory Failure, Pneumonia, Viral, COVID
- Trial name
- COVIDNOCHE (NCT04381923)
- Testing
- Helmet Continuous Positive Airway Pressure (CPAP), High Flow Nasal Oxygen (HFNO)
- Where
- United States
- Sponsor
- University of Pennsylvania
Pneumonia, Vitamin D Deficiency
Kabul Vitamin D Supplementation Trial
Background: Pneumonia is the leading cause of childhood mortality, accounting for 19% of the 10.6 million deaths that occur each year1.
- Trial name
- NCT00548379
- Testing
- vitamin D
- Where
- 2 sites in Afghanistan
- Volunteers
- 3,048 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Severe Influenza, Intensive Care (ICU)
Early Corticosteroids in Severe Influenza Pneumonia
This is a Phase III, multicentre, randomized, controlled, double-blind, superiority trial aiming to evaluate the efficacy of dexamethasone versus placebo in patients admitted to intensive care or intermediate care with influenza…
- Conditions
- Severe Influenza, Intensive Care (ICU), Reanimation, Infectious Diseases
- Trial name
- ECSIP (NCT07786662)
- Testing
- Dexametasone
- Where
- 48 sites in France
- Volunteers
- 544 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
COVID-19 Infection, Cancer Patients
COVID19-Convalescent Plasma for Treating Patients With Active Symptomatic COVID 19 Infection (FALP-COVID)
COVID-19 infection has spread worldwide causing several deaths in few months Convalescent Plasma from COVID 19 donors has shown huge activity in small series from Chinese patients and currently many centers from USA and the…
- Conditions
- COVID-19 Infection, Cancer Patients, General Population
- Trial name
- FALP-COVID (NCT04384588)
- Testing
- Convalescent Plasma from COVID-19 donors
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Fundacion Arturo Lopez Perez
COVID-19 Pandemic, Health Knowledge, Attitudes, Practice
Baby2Home (B2H) Mobile Health Application
The COVID-19 pandemic has transformed healthcare delivery; arguably, the fields of obstetrics and pediatrics have experienced some of the greatest changes as they have transitioned away from their role as a medical home and into…
- Conditions
- COVID-19 Pandemic, Health Knowledge, Attitudes, Practice, Perinatal Depression, Mental Health Wellness
- Trial name
- NCT05595486
- Testing
- Baby2Home Mobile Application
- Where
- 2 sites in United States
- Volunteers
- 642 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Pneumonia
Evaluation of an Oral Nutritional Supplement in Older Hospitalized Patients
Study objectives are to verify the loss of lean mass during a hospital stay in a group of older patients; to evaluate the effects of consuming a high-calorie complete and balanced oral nutritional supplement; to collect…
- Trial name
- NCT01477723
- Testing
- Experimental Oral Nutritional Supplement
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 17 people
- Sponsor
- Abbott Nutrition
COVID-19
Plasma Immunity of Mild SARS-CoV-2 Omicron and Delta Pandemic in Thailand
The investigators assessed the effect of treatment for COVID and immunity of the volunteers who admitted to the home isolation.
- Trial name
- NCT05328479
- Where
- Thailand
- Volunteers
- 5,181 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Long-COVID, Brain Fog
Effect of Daily Walnut Consumption on Memory in Subjects With Long-COVID
Approximately 30% of patients experience "Long-COVID" syndrome presenting with symptoms such as cognitive difficulties ('brain fog'), fatigue, dyspnea, autonomic dysfunction, depression and anxiety, lasting beyond 12 weeks…
- Conditions
- Long-COVID, Brain Fog, Cognition, Memory
- Trial name
- NCT07429903
- Testing
- whole food - walnuts
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of California, Los Angeles
Healthy Older Adults Ages 60-89
Longitudinal Innate Immunity and Aging Study
This study plans to examine biological bases of cognitive aging. The goals of the study are to better understand how immune system markers, measured in the blood and in the spinal fluid, are related to clinical features of aging…
- Trial name
- LIIA (NCT03944603)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Influenza, COVID-19
Patient-Centered Practical Vaccine Talk For Busy Clinicians
The goal of this study is to assess the effect of an educational intervention for primary care providers (PCPs) on influenza and COVID-19 vaccine uptake among their adult patients through a pragmatic, cluster randomized trial in…
- Trial name
- PCP-VAX (NCT07651761)
- Testing
- Provider communication training
- Where
- United States
- Volunteers
- 24,500 people
- Sponsor
- University of Massachusetts, Worcester
COVID-19 Infection
PREDICT: A PBRN Feasibility Study on COVID-19 Screening in Dental Practice
The study team will conduct a feasibility study to develop and test out procedures for improved triage and COVID-19 testing in dental practices to increase safety and perceptions of the safety of Dental Health Care Workers (DHCW)…
- Trial name
- PREDICT (NCT05123742)
- Testing
- COVID-19 Testing
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
COVID 19
Neuropathology in Adults Intensive Care Unit Patients With COVID 19
This is a single center observational autopsy study, conducted during the first wave of the coronavirus disease (COVID-19) pandemic in France.
- Trial name
- NCT04453670
- Testing
- autopsy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University of Versailles
COVID-19
Interferon Gamma Induced Protein 10 (IP-10) in a Clinical Decision Support Protocol in COVID-19 Patients
The proposed project will pilot incorporation of rapid serial measurements of IP-10 into a CDS tool for moderate and severe COVID-19 patients.
- Trial name
- NCT04389645
- Testing
- IP-10 in CDS protocol
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- MeMed Diagnostics Ltd.
Asthma, COPD
Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections.
- Conditions
- Asthma, COPD, Bacterial Pneumonia, Viral Pneumonia
- Trial name
- OXIGENE (NCT07386912)
- Testing
- Characterization of the neutrophil granulocyte epigenome, Characterization of the T-cell immune response to to various oxidatively modified mycobacterial antigens
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Research Center Borstel
COVID-19
Mesenchymal Stem Cell Secretome In Severe Cases of COVID-19
This study is a multi-centre randomized controlled trial involving severe covid-19 patients. The intervention group will receive mesenchymal stem cell secretomes and standard covid-19 therapy, while the control group receive…
- Trial name
- NCT05122234
- Testing
- Injection of secretome - mesenchymal stem cell, Standard treatment of Covid-19
- Where
- 4 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
COVID-19, Endothelial Dysfunction
The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05185934
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Atelectasis, Acute Respiratory Distress Syndrome
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients
Mechanical ventilation is an important treatment modality for intensive care unit (ICU) patients, but it also brings a series of problems such as ventilator-associated pneumonia, ventilator-induced lung injury, and atelectasis.
- Conditions
- Atelectasis, Acute Respiratory Distress Syndrome, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT06662630
- Testing
- High-Frequency Oscillatory Ventilation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
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