Clinical trials: Pneumonia Childhood
Pneumonia, Human Immunodeficiency Virus (HIV)
CPAP Improving Mortality for Pneumonia in African Children Trial
Pneumonia mortality rates in African countries like Malawi are high and increased further in children -exposed or infected with human immunodeficiency virus (HIV) as well as those that are severely malnourished or severely…
- Conditions
- Pneumonia, Human Immunodeficiency Virus (HIV), Malnutrition, Hypoxemia
- Trial name
- IMPACT (NCT02484183)
- Testing
- bubble continuous positive airway pressure (CPAP)
- Where
- Malawi
- Volunteers
- 646 people
- Sponsor
- Johns Hopkins University
Health Behavior
Effect of Social Accountability on Improving Service Delivery and Outcomes in the Public Sector in Uttar Pradesh, India
In several low and middle-income countries, Social Accountability (SA) interventions have been introduced as an innovative approach to governance, aiming to improve delivery of public services.
- Trial name
- D0168 (NCT02879708)
- Testing
- Information Only, Information and Facilitation
- Where
- India
- Volunteers
- 105,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pneumonia Childhood
Thoracic KT on Pulmonary Function Ichildren with Pneumonia
This study aimed to investigate the effect of thoracic kinesio-tape on Pulmonary Functions, time to clinical resolution and respiratory rate and arterial oxygen saturation in children with pneumonia.
- Trial name
- NCT06573047
- Testing
- kinesotape, Chest physiotherapy exercises
- Volunteers
- 40 people
- Sponsor
- Cairo University
Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs)
Validation of the EQ-5D-Y-3L and EQ-5D-Y-5L for Paediatric Patients in China
The goal of this observational study is to validate the EQ-5D-Y-3L and EQ-5D-Y-5L in measuring health-related quality of life (HRQoL) for paediatric patients with different health conditions in China.
- Conditions
- Quality of Life (QOL), Patient-Reported Outcome Measures (PROMs), Pneumonia Childhood, Neuroblastoma (NB)
- Trial name
- NCT06873672
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Pneumonia, Childhood Pneumonia
Diagnostic Accuracy of Lung Ultrasound for Pneumonia Diagnosis in Children
Chest X-ray is historically being used as an imaging standard to aid to the diagnosis of childhood pneumonia, however, the evidence does not support it as a perfect imaging tool.
- Trial name
- LUS (NCT07331311)
- Testing
- LUS as a chest imaging tool
- Where
- Nepal
- Volunteers
- 320 people
- Sponsor
- Nagasaki University
Pneumonia, Childhood Pneumonia
Pneumonia Case Management Practices in Pakistan
Pneumonia in Pakistan continues to be the leading killer of children under five. Although various national and provincial programs have tried to tackle this but they have not been able to achieve the desired outcomes.
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT03869099
- Testing
- Pneumonia Case Management Practices
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Edinburgh
Pneumonia Childhood, Intensive Care Unit
Effect Of Cough Assist Device On Hemodynamic Status And Oxygen Saturation For Ventilated Children
Statement of the problem: •Is there an effect of the cough assist device on Hemodynamic status and oxygen saturation for ventilated children? Null hypothesis There will be no effect of cough assist device on hemodynamic status…
- Conditions
- Pneumonia Childhood, Intensive Care Unit, Children
- Trial name
- NCT06154876
- Testing
- Cough assist device
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Chronic Graft-versus-Host-Disease, Leukemia
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults…
- Conditions
- Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer
- Trial name
- NCT04372524
- Where
- 16 sites in United States, Canada
- Volunteers
- 350 people
- Sponsor
- University of British Columbia
Low Fluid Intake, Chronic
Water Intervention for Thinking in Kids (WITiKids ) Study
The aim of this study is to determine the influence of changes in water intake on changes in cognitive function among preadolescent children.
- Trial name
- WITiKids (NCT02816450)
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Pneumonia
Observation and Treatment of Pulmonary Microthrombosis in Childhood Pneumonia With Elevated D-dimer
Objective 1. Master the clinical feathers, imaging features and laboratory diagnosis characteristics and economic costs of children pneumonia with higher D-dimer: 1.
- Trial name
- NCT04778917
- Testing
- Low-Molecular-Weight Heparins Calcium Injection
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Capital Institute of Pediatrics, China
Diarrhea, Pneumonia
64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings
The purpose of this study is to compare the occurrence of childhood diarrheal disease and pneumonia in subjects under the age of 5 years in low resource settings who have received prophylactic 64N nutraceutical (64N)as a neonate…
- Trial name
- NCT02231047
- Testing
- 64N Nutraceutical, No 64N Nutraceutical
- Where
- Guatemala
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- H2O Health and Agriculture LLC
Severe Acute Malnutrition in Childhood, Pneumococcal Disease
Opportunistic Pneumococcal Immunisation Trial in MALnutrition
The goal of the OPTIMAL clinical trial is to learn if a dose of a pneumococcal conjugate vaccine (PCV) generates a good immune response in young children who are in hospital with severe acute malnutrition.
- Conditions
- Severe Acute Malnutrition in Childhood, Pneumococcal Disease, Pneumococcal Vaccines, Pneumococcal Infection
- Trial name
- OPTIMAL (NCT06817421)
- Testing
- Pneumococcal conjugate vaccine, Typhoid conjugate vaccine
- Where
- Timor-Leste
- Volunteers
- 214 people
- Sponsor
- Nick Fancourt
Community Acquired Pneumonia in Children, Mycoplasma Pneumoniae
A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced…
- Conditions
- Community Acquired Pneumonia in Children, Mycoplasma Pneumoniae, Mycoplasma Pneumoniae Pneumonia
- Trial name
- MYTHIC (NCT06325293)
- Testing
- Azithromycin Pfizer®
- Where
- 13 sites in Switzerland
- Volunteers
- 376 people
- Sponsor
- Christoph Berger
Sars-CoV2, Covid-19
COPE - COVID-19 in Pregnancy and Early Childhood
Purpose: The emergence of a new coronavirus SARS-CoV-2 causing a novel infection in the human race resulting in a world-spanning pandemic came as a surprise and at a tremendous cost both for individual human lives as well as for…
- Conditions
- Sars-CoV2, Covid-19, Pregnancy Complications, Pregnancy Preterm
- Trial name
- COPE (NCT04433364)
- Testing
- biological samples, questionnaires and interviews
- Where
- 27 sites in Sweden
- Volunteers
- 3,834 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Respiratory Infections in Children
Trial of an AI-enabled Digital Stethoscope to Improve Antibiotic Stewardship
Antibiotics are a mainstay of the treatment of lower respiratory infections in young children even though most episodes are caused by self-limiting viruses.
- Trial name
- BLAAAST (NCT07362433)
- Testing
- Automated digital stethoscope
- Where
- Bangladesh
- Volunteers
- 2,500 people
- Sponsor
- Johns Hopkins University
Childhood Severe Illness, Pneumonia
Tools for the Integrated Management of Childhood Illness: Cross-country Quasi-experimental Pre-post Study in Kenya and Senegal
By introducing pulse oximetry, with or without clinical decision support algorithms, to primary care facilities in India, Kenya, Senegal and Tanzania, the Tools for Integrated Management of Childhood Illness (TIMCI) project aims…
- Conditions
- Childhood Severe Illness, Pneumonia, Primary Health Care, Hypoxia
- Trial name
- TIMCI (NCT05065320)
- Where
- 2 sites in Kenya, Senegal
- Volunteers
- 51,590 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Pneumonia, Childhood Pneumonia
Online Learning Portal on Under Five Pneumonia
Despite the availability of standard pneumonia management guidelines and multiple global efforts, pneumonia continues to be the leading killer of children under five, accounting to around 17% of the total under five deaths…
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT04495361
- Testing
- E-learning portal
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- University of Edinburgh
Pneumonia Childhood
Severe Pneumonia Diagnostic in Pediatric Population by Lung Ultrasonography and Procalcitonin
Lung ultrasound (LUS) in combination with a biomarker has not yet been studied. The investigators propose a clinical trial where the primary aims are: 1.
- Trial name
- PROLUSP (NCT04217980)
- Testing
- Lung ultrasonography (LUS) or Chest X ray (CXR)
- Where
- 2 sites in Spain
- Volunteers
- 202 people
- Sponsor
- Fundació Sant Joan de Déu
Pneumonia Childhood
Effectiveness Trial of Day-care vs. Usual Care of Severe Pneumonia & Malnutrition in Children
Background: At present pneumonia and malnutrition have become the leading causes of mortality among <5-year-old children in developing countries.
- Trial name
- Day-care (NCT02669654)
- Testing
- Day-care management of Severe Pneumonia
- Where
- 2 sites in Bangladesh
- Volunteers
- 4,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pneumonia
Host Response and Pathogen Genomics in Childhood Respiratory Infection
A major challenge in children's infections is that it is difficult to work out which bug is making them unwell. Tests can find the bugs that are present though there can be more than one.
- Trial name
- INTERACT (NCT07545096)
- Testing
- Non-Interventional Study
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust