Clinical trials: Point of Care Testing
Validation, Biosensors
Validation of New G6PD Point of Care Tests Against Gold Standard Quantitative
This is a laboratory research to evaluate performances of quantitative POC G6PD tests (Biosensors) against gold standard quantitative laboratory based tests and genotyping.
- Conditions
- Validation, Biosensors, Genotyping
- Trial name
- Biosensors (NCT02625285)
- Where
- Thailand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Liver Diseases, Healthy
Blood Collection for Development and Validation of Point-of-Care Diagnostic Liver Function Tests
This is an observational study exploring the performance of a novel point-of-care diagnostic testing platform designed to quantitate the presence of liver function biomarkers such as bilirubin.
- Conditions
- Liver Diseases, Healthy, Liver Cirrhosis, Liver Fibrosis
- Trial name
- NCT05457543
- Testing
- Adult
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Group K Diagnostics Inc.
Syphilis
Point of Care Tests for Syphilis and HIV
This study will evaluate the performance of two point-of-care dual syphilis and HIV tests [Multiplo TP/HIV test (MedMira Inc, Halifax, Nova Scotia) and the INSTI Multiplex HIV-1/HIV-2/Syphilis Antibody Test (bioLytical…
- Trial name
- PoSH (NCT04514848)
- Testing
- INSTI Multiplex HIV-1/2 Syphilis AB test, Multiplo Rapid TP/HIV test
- Where
- Canada
- Volunteers
- 1,526 people
- Sponsor
- University of Alberta
NSCLC, Melanoma
Breathomics as Predictive Biomarker for Checkpoint Inhibitor Response
Immunotherapy with agents stimulating the immune system to act against cancer are now a new standard of care in various cancers as lung cancer and melanoma, but also bladder cancer, kidney cancer and head \& neck cancer.
- Conditions
- NSCLC, Melanoma, Kidney Cancer, Urothelial Carcinoma
- Trial name
- NCT04146064
- Testing
- Breathprint analysis and patient-reported outcomes
- Where
- Canada
- Volunteers
- 190 people
- Sponsor
- University Health Network, Toronto
Blood, Point-of-Care Systems
Examination of the Time Advantage Between POCT and Conventional Central Laboratory Analysis
The aim of the present study is to quantify the time advantage achieved by the use of POCT compared to conventional coagulation diagnostics.
- Conditions
- Blood, Point-of-Care Systems, Analysis, Event History
- Trial name
- NCT03242525
- Testing
- POCT and central laboratory blood analysis
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Diabetes Mellitus, Type 2, Liver Diseases
Validate Smart Breath Analyzer as Screening Tool for Diabetic, Hepatic, Renal, Lung, and Other Metabolic Disorders
This is a prospective, multicentric, non-treatment study to build and validate a portable, non-invasive smart breath analyzer that can screen underlying health issues using exhaled breath.
- Conditions
- Diabetes Mellitus, Type 2, Liver Diseases, Kidney Diseases, Lung Diseases
- Trial name
- RESPYR-SBA (NCT07646015)
- Where
- India
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Respyr
Hepatocellular Carcinoma
InstaSure™ Non-Invasive Finger-Press Test for Hepatocellular Carcinoma
This prospective observational case-control study evaluates the InstaSure™ Non-Invasive Finger-Press Test for hepatocellular carcinoma (HCC).
- Trial name
- NCT07848750
- Testing
- InstaSure™ Non-Invasive Finger-Press Test
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing Municipal Administration of Hospitals
Tuberculosis
Evaluating Next Generation LAM Assays and Molecular Diagnostics (POC and Near POC) for the Diagnosis of TB Among People With Presumptive TB: a Prospective Multicentre Diagnostic Accuracy Study
This prospective multicentre study is planned to evaluate the next generation LAM assays and molecular diagnostics (POC and near POC) among people with presumptive Tuberculosis.
- Trial name
- DriveDx4TB (NCT06019052)
- Volunteers
- 1,890 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Acute Coronary Syndromes
Point-of-Care Troponin Testing in the Emergency Department
The goal of this study is to evaluate whether a POC-guided testing strategy to exclude non-ST elevation myocardial infarction (NSTEMI) in acute chest pain patients presenting at the emergency department (ED) can result in a…
- Trial name
- CERMIT (NCT06845826)
- Testing
- Point-of-Care high-sensitivity troponin testing
- Where
- Belgium
- Volunteers
- 1,552 people
- Sponsor
- KU Leuven
Ebola Virus Disease
Evaluation of the FilmArray BioThreat-E Test
The aim of our study is to assess the analytical and clinical performance of the FilmArray (FA) BioThreat-E test (BioFire®) for the diagnosis of Ebola virus disease in the field in Guinea versus conventional molecular techniques.
- Trial name
- NCT02658331
- Volunteers
- 156 people
- Sponsor
- BioMérieux
Heart Diseases
POC - Transfusion Algorithm Cardiac Study
This multi-centre study will provide sound, generalizable data on the effectiveness of a POC-based algorithm to determine to what extent this guideline can reduce blood product transfusions.
- Trial name
- TACS (NCT02200419)
- Testing
- POC-based transfusion algorithm
- Where
- 12 sites in Canada
- Volunteers
- 7,402 people
- Sponsor
- University Health Network, Toronto
Apical Periodontitis
Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis
To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician…
- Trial name
- PoCT ELISA (NCT06701266)
- Testing
- Point of Care Test
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Manipal University College Malaysia
Chest Pain, Myocardial Infarction
Rule Out of ACS in Primary Care Using a Decision Rule for Chest Pain Including Hs-troponin I POCT
The goal of this clustered, diagnostic randomized controlled trial is to study a clinical decision rule including a high-sensitive troponin I point of care test in patients with chest pain in primary care.
- Conditions
- Chest Pain, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- POB HELP (NCT05827237)
- Testing
- Clinical decision rule
- Where
- Netherlands
- Volunteers
- 946 people
- Sponsor
- Leiden University Medical Center
Sepsis
Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults
Trial design: Randomised controlled, two-arm, parallel, clinical trial to assess the efficacy and safety of sequential daily procalcitonin assessments to guide de-escalation of empirical antibiotic therapy in adult patients with…
- Trial name
- PROCALBAN (NCT05955612)
- Testing
- Procalcitonin measurement
- Where
- Bangladesh
- Volunteers
- 532 people
- Sponsor
- University of Oxford
Drug Resistance
Danish Aspirin Resistance Trial - Pilot Study
Despite treatment with aspirin a large number of patients suffer a myocardial infarction. It has been speculated that these patients might be "resistant" to aspirin, and studies have indicated that this phenomenon is related to a…
- Trial name
- NCT00389129
- Testing
- acetylsalicylic acid
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pneumonia, Childhood Pneumonia
Diagnostic Accuracy of Lung Ultrasound for Pneumonia Diagnosis in Children
Chest X-ray is historically being used as an imaging standard to aid to the diagnosis of childhood pneumonia, however, the evidence does not support it as a perfect imaging tool.
- Trial name
- LUS (NCT07331311)
- Testing
- LUS as a chest imaging tool
- Where
- Nepal
- Volunteers
- 320 people
- Sponsor
- Nagasaki University
Point-of-Care Testing
Point Of Care Testing In Danish General Practice
The aim of this project is to evaluate the efficacy of electronic reminder letters versus postal reminder letters on general practices adherence to clinical quality guidelines regarding Point Of Care Testing (POCT).
- Trial name
- POCIP (NCT01152151)
- Testing
- Postal reminder letters, Electronic reminder letters, Reminder letters
- Where
- Denmark
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Research Unit Of General Practice, Copenhagen
Acute Respiratory Infection
ASPIRE II. Supporting Antibiotic Stewardship in Primary Care Via POCT
Acute Respiratory Infections (ARIs) are a major contributor to antibiotic resistance, largely due to the over prescription of antibiotics driven by the subjective nature of clinical assessment.
- Trial name
- ASPIRE II (NCT06981130)
- Testing
- FebriDx Point of Care Test
- Where
- 3 sites in United Kingdom
- Volunteers
- 144 people
- Sponsor
- University of South Wales
Viral Conjunctivitis
ADenoVirus Initiative Study in Epidemiology in Germany
The objectives of this study is to assess the characteristics and frequency of adenovirus conjunctivitis in a population of male and female patients from one year of age who present signs and symptoms of acute conjunctivitis.
- Trial name
- NCT02054273
- Where
- 13 sites in Germany
- Volunteers
- 240 people
- Sponsor
- NicOx
Liver Diseases, Healthy
Validation of Point of Care Liver Function Tests
This study is testing the accuracy of a point of care device that tests liver function within 20 minutes. The target population will be any adult who had liver function tests ordered and to be drawn on the same day as enrollment.
- Conditions
- Liver Diseases, Healthy, Cirrhosis, Liver, Fibrosis
- Trial name
- NCT03800069
- Testing
- Group K Diagnostic point of care device
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania