Clinical trials: Point-of-Care Systems
Intussusception, Emergencies
Point-of-Care Ultrasonography for Intussusception
Pediatric emergency medicine (PEM) physicians are increasingly utilizing point-of-care ultrasound (POCUS). There is currently limited data regarding POCUS evaluation for intussusception in pediatric patients.
- Trial name
- NCT03360643
- Testing
- Point-of-care ultrasound prior to radiology ultrasound, Radiology-performed ultrasound
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Hydrostatic Pulmonary Edema, Acute Respiratory Failure
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema.
- Conditions
- Hydrostatic Pulmonary Edema, Acute Respiratory Failure, Dyspnea
- Trial name
- DYSP-ED-US (NCT07324980)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Sinusitis Bacterial
Point-of-Care Immunoassay for Detection of Bacterial Sinusitis
This study is conducted to evaluate the performance of a rapid, point-of-care in vitro diagnostic device (Sinu-Test®) for the qualitative detection of the three most common pathogens responsible for causing bacterial sinusitis.
- Trial name
- NCT03584737
- Testing
- rapid in vitro diagnostic test, bacterial culture, PCR assay
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- ENTvantage Dx
Ebola Virus Disease, Malaria
Mobile Point of Care Diagnostic Testing for Ebola Virus Disease in DRC
A mobile suitcase laboratory for EBOV point-of-care (POC) detection at Ebola treatment centers was successfully implemented in Guinea during the large Ebola virus disease (EVD) outbreak in West-Africa 2014-2015.
- Conditions
- Ebola Virus Disease, Malaria, Typhoid Fever, Dengue Fever
- Trial name
- MobEboDRC (NCT04235361)
- Testing
- Differential RPA tests
- Where
- 4 sites in Canada, Democratic Republic of the Congo and 2 more
- Volunteers
- 500 people
- Sponsor
- University of Stirling
Hypoglycemia, Hyperglycemia
Exploration of Continuous Glucose Monitoring on the Intensive Care Unit
Both hyperglycemia and hypoglycemia in patients at the intensive care unit (ICU) are strongly associated with increased morbidity and mortality.
- Trial name
- CGM-IC (NCT06645873)
- Testing
- Continuous glucose monitoring (CGM) device
- Where
- 3 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Kim Kamphorst
Anemia, Iron Deficiency, Iron Overload
Validation of a Point-of-care Device Measuring Ferritin With Capillary Blood
Measurement of iron is important for identifying both low and high iron levels in the body. Measuring a protein in the blood called ferritin is currently the easiest way to determine a patient's iron status.
- Conditions
- Anemia, Iron Deficiency, Iron Overload, Iron-deficiency
- Trial name
- FerPOC (NCT03800446)
- Testing
- Point of care ferritin test
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Cholecystitis, Acute, Biliary Diseases
Repeat Biliary Point of Care Ultrasound for Detecting Early Acute Cholecystitis
The goal of this interventional, prospective study is to determine the clinical utility of a repeat point-of-care ultrasound of the gallbladder in adult emergency department patients with abdominal pain for which initial imaging…
- Trial name
- NCT07792200
- Testing
- Repeat biliary point of care ultrasound
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- WellSpan Health
Jaundice, Neonatal, Hyperbilirubinemia
Point-of-Care System for Determination of Bilirubin Capacity in Neonates
The aims of this observational bench project are to validate the performance of the miniaturized and modernized hematofluorometer that measures bilirubin capacity into a product and is suitable for operation in various point of…
- Conditions
- Jaundice, Neonatal, Hyperbilirubinemia, Bilirubin-Induced Neurological Dysfunction (BIND)
- Trial name
- NCT02612207
- Testing
- Bilirubin Binding Capacity by Hematofluorometry Validation
- Where
- 2 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Stanford University
Gram Negative Infections, Sepsis and Septic Shock
A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections
The goal of this clinical trial is to : 1. Test whether the combination of CAZ±AVI and FOS leads to superior clinical outcomes in patients with severe suspected Gram-negative bacterial infection, as demonstrated by a shorter time…
- Trial name
- CAVIFOS (NCT07063095)
- Testing
- Ceftazidime± avibactam with fosfomycin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Angela HUTTNER
Neonatal, Asphyxia
Evaluation of Lactate Dehydrogenase as Decision Support for Admissions to Neonatal Ward
The immediate newborn period is the period of highest morbidity in life. Early signs of serious disease are often vague and difficult to interpret for the non- specialist.
- Trial name
- HildaNeoHan (NCT02379936)
- Testing
- The Neo Hilda, Traditional evaluation, iPhone 4S
- Where
- Vietnam
- Volunteers
- 122 people
- Sponsor
- National Children's Hospital, Vietnam
DEEP VEIN THROMBOSIS
Point of Care Ultrasound (US) Versus Detailed Radiology US for Deep Vein Thrombosis (DVT)
We propose an observational study to assess the ability of intensivists to evaluate for deep vein thrombosis using 2 point compression ultrasonography.
- Trial name
- NCT01045759
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Neoplasia of the Uterine Cervix, Cancer Prevention
HRME: Screening for Cervical Cancer and Its Precursors in Low-Resource Settings
A new mobile diagnostic and treatment unit is being developed by BCH to address the loss-to follow-up associated with the mobile screening program and demonstrate POC diagnosis by HRME.
- Conditions
- Neoplasia of the Uterine Cervix, Cancer Prevention, Cervical Intraepithelial Neoplasia
- Trial name
- HRME-UH2 (NCT02494310)
- Testing
- High-Resolution Microendoscopy Imaging
- Volunteers
- 200 people
- Sponsor
- Barretos Cancer Hospital
Pneumonia
Lung Ultrasound in Pediatric CAP
Community-acquired Pneumonia (CAP) represents the single largest cause of death and morbidity in children worldwide (1). Respiratory viruses are the most common cause of CAP in preschool children, followed by bacteria.
- Trial name
- ULTRASONIC-CAP (NCT05741203)
- Testing
- lung ultrasound
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sickle Cell Disease
Development and Evaluation of an Information Management System and Communication System for Population-wide Point-of-care Infant Sickle Cell Disease Screening
Although over 75% of children with sickle cell disease (SCD) are born in sub-Sahara where the disease highly contributes to under-5 mortality and causes life-long debilitation, evidence-based strategies to control SCD are not…
- Trial name
- SIMCS SCD (NCT06563440)
- Testing
- Digital app and information system
- Where
- 2 sites in United States, Uganda
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Pediatric Ankle Fracture
Point-of-Care Ultrasonography for Pediatric Ankle Fracture Detection
This prospective observational study evaluated the diagnostic accuracy of point-of-care ultrasonography (POCUS) for detecting ankle fractures in children presenting to the emergency department with acute isolated ankle trauma.
- Trial name
- NCT07872124
- Testing
- Point-of-Care Ultrasonography (POCUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pulmonary Embolism
Point-of-Care Ultrasound in Predicting Adverse Outcomes in Emergency Department Patients With Acute Pulmonary Embolism
This study is an observational, prospective study examining the role point-of-care echocardiography of predicting short term adverse outcomes in emergency department patients with acute pulmonary embolism.
- Trial name
- NCT05050617
- Testing
- Point-of-care echocardiography
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- WellSpan Health
Colorectal Cancer Screening
Point of Care, Real-Time Urine Metabolomics Test to Diagnose Colorectal Cancers and Polyps in Low-and Middle-Income Countries
Study description: the study is a clinical trial aimed at assessing the validity of a point-of-care tool developed for colorectal cancer screening using urine metabolites.
- Trial name
- NCT05679960
- Testing
- Urine PolypDx machine Versus Colonoscopy
- Where
- Nigeria
- Volunteers
- 645 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Dyspnea, Respiratory Distress Syndrome
LUng and Cardiac Ultrasound for REspiratory Distress in ElDerly
Prospective trial to evaluate the impact on the initial therapeutic inadequacy of a management strategy for acute dyspnea in the elderly based on the use of lung and cardiac ultrasonography.
- Trial name
- LUCREED (NCT06807983)
- Testing
- diagnostic strategy based on lung and cardiac ultrasonography
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Toulouse
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