Clinical trials: Polycystic Ovarian Syndrome (PCOS)
PCOS, Insulin Resistance
Myoinositol Treatment and Asprosin Levels in PCOS
Policystic ovary syndrome is the most common endocrinopthy during reproductive period. One of the factors implicated in the pathogenesis is insulin resistance.
- Trial name
- NCT05951309
- Testing
- inofolic combi, Glucophage 500Mg Tablet
- Where
- Cyprus
- Volunteers
- 30 people
- Sponsor
- Near East University, Turkey
Polycystic Ovarian Syndrome
Follicular Synchronization in PCOS Patients Undergoing ICSI
The use of GnRH antagonist protocol nowadays is the slandered protocol of controlled ovarian stimulation in patients with poly cystic ovarian syndrome (PCOS) because it decreases the incidence of OHSS(1, 2).
- Trial name
- NCT04069117
- Testing
- letrozole 2.5mg (Femara; Novartis Pharma Services, Basel, Switzerland)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University Hospital
Polycystic Ovary Syndrome
Treatment of Adolescent Polycystic Ovary Syndrome (PCOS)
A 24 week study to compare the use of Metformin, birth control pills and a carefully planned intensive lifestyle program that includes weight loss and exercise.
- Trial name
- NCT00714233
- Testing
- Metformin, Oral Contraceptive Pills (Yasmin), Lifestyle Modification
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Polycystic Ovary Syndrome
Role of the Ketogenic Diet in Women With PCOS
For the fact of PCOS symptoms could be improved with weight loss and improving insulin resistance, the investigators will do this study to evaluate the role of the ketogenic diet in overweight and obese women with PCOS.
- Trial name
- NCT04175964
- Testing
- ketogenic diet, caloric diet with Metformin, caloric diet
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Obesity, Polycystic Ovary Syndrome
Treatment of Obesity With Topiramate in Patients With Polycystic Ovary Syndrome
Treatment of obesity related to Polycystic Ovary Syndrome with topiramate or placebo to assess improvement of clinical and laboratory parameters after 6 months of follow-up
- Conditions
- Obesity, Polycystic Ovary Syndrome, Hyperandrogenism
- Trial name
- NCT04453306
- Testing
- Topiramate
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
The Frequency of Polycystic Ovary Syndrome Among Young Reproductive Females Presenting With Hyperandrogenism: a Mixed Cohort Study
This mixed cohort study will test the frequency of PCOS among young females presenting with one of the clinical hyperandrogenism criteria: acne, hirsutism and/or hair loss.
- Trial name
- NCT05734287
- Testing
- clinical, biophysical and biochemical assessment of young females with clinical hyperandrogenism
- Where
- Qatar
- Volunteers
- 260 people
- Sponsor
- Woman's Health University Hospital, Egypt
Polycystic Ovary Syndrome
CANA/Met in Non-diabetic Women With PCOS
Polycystic ovary syndrome (PCOS), which is associated with hyperinsulinaemia, hyperandrogenaemia, impaired glucose metabolism and aberrant adipokines production from the adipose tissue, is a heterogeneous reproductive and…
- Trial name
- NCT04973891
- Testing
- Canagliflozin combined with metformin, metformin
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Shengjing Hospital
Polycystic Ovary Syndrome
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction
Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovaries. Insulin resistance (IR) is a common feature of PCOS, and the resultant hyperinsulinemia is theorized to promote…
- Trial name
- TIN-PCOS-AOD (NCT03229408)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
PCOS and US Cavitation
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Women with this syndrome may have infrequent menstrual periods or amenorrhea and excess androgen levels.
- Trial name
- NCT05880550
- Testing
- ultrasound cavitation in addition to aerobic ex, aerobic exercises.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Healthy
Vitamin D Treatment, Pharmacogenetics and Glucose Metabolism
Background: Polycystic ovary syndrome (PCOS) is as common as 5-10% of all women in Austria. PCOS women frequently present with metabolic disturbances, hyperandrogenism and infertility. New therapy concepts are warranted.
- Conditions
- Polycystic Ovary Syndrome, Healthy, Vitamin D Deficiency
- Trial name
- NCT01721915
- Testing
- Vitamin D supplementation
- Where
- Austria
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Myoma;Uterus, Vitamin D Deficiency
Vitamin D Levels And Myoma Uteri
Women with at least one uterine leiomyoma and polycystic ovary syndrome over 10 mm and women with normal ultrasonographic findings were included in the study.
- Conditions
- Myoma;Uterus, Vitamin D Deficiency, Polycystic Ovary
- Trial name
- NCT03871868
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Polycystic Ovary Syndrome
Inositol Treatment in Different Type of PCOS Phenotype
Evaluation of the efficacy of inositol treatment in women with PCOS in relation to the phenotype (according to the Rotterdam Criteria)
- Trial name
- NCT05678114
- Testing
- Myo-inositol
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Lo.Li.Pharma s.r.l
Pregnancy Complications, Delivery Complications
CoPPer Study - Complications of Polycystic Ovary Syndrome (PCOS) Pregnancy: Evaluating Risk
The CoPPer study is a follow-up study of women diagnosed with Polycystic Ovary Syndrome (PCOS). Women will be included pre-conceptional and followed-up until after delivery.
- Conditions
- Pregnancy Complications, Delivery Complications, Neonatal Complications
- Trial name
- CoPPer (NCT00821379)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht
Polycystic Ovary Syndrome
Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study
To investigate the effect of metformin on pregnancy complications and pregnancy outcome in the II. and III. trimester of pregnancy in women with polycystic ovary syndrome.
- Trial name
- pilPregMet (NCT03259919)
- Testing
- Metformin
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Norwegian University of Science and Technology
Polycystic Ovary Syndrome
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Hypothesis The overall hypothesis is that non-obese (BMI <30) women with PCOS have high luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated low-frequency EA restore these alterations and induce…
- Trial name
- PCOSLFEA (NCT00921492)
- Testing
- Low-frequency electro-acupuncture (EA), Meeting a therapist - attention control
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Göteborg University
Polycystic Ovary Syndrome, Reproductive Medicine
Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome
The main objective will be to check if MyoInositol (MYO) reduces the total resistance rate to Clomiphene Citrate (CC). For this, our study will be controlled, randomized and double blinded.
- Trial name
- MYOPK (NCT03059173)
- Testing
- Myo-Inositol + Levomefolic acid, Clomiphene Citrate
- Where
- France
- Volunteers
- 276 people
- Sponsor
- University Hospital, Lille
Polycystic Ovary Syndrome, Anovulatory
Endometrial Thickness and Subendometrial Vascularity in Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin
The participants will receive metformin 500mg 3times per day for 3months and one month is left for spontaneous pregnancy to occur or not (primary outcome ) and the investigators will check endometrial thickness and…
- Trial name
- NCT03486626
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Ain Shams Maternity Hospital
PCO - Polycystic Ovaries, Infertility
Mild Stimulation Protocol Using Clomiphene Citrate for Women With PCOS Undergoing in Vitro Fertilization
Infertility is of increasing significance affecting almost 48.5 million couples around the world. Anovulation is a major cause of infertility in women with polycystic ovary syndrome (PCOS) accounting for about 80% of women with…
- Trial name
- NCT04157725
- Testing
- mild stimulation protocol: oral Clomiphene Citrate, Conventional Stimulation Protocol: will receive FSH/HMG
- Where
- Lebanon
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Infertility, PCOS
Metformin in Patients With PCOS and Predictors of Poor Ovarian Response Ongoing In-vitro Fertilization
Metformin should be administered with caution and could be potentially dangerous in infertile patients with PCOS who show a poor ovarian response and are undergoing gonadotropin-based ovarian stimulation.
- Conditions
- Infertility, PCOS, Prognosis for Poor Response
- Trial name
- NCT01208740
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University Magna Graecia
Polycystic Ovary Syndrome
Improved Effects of MI Plus Alpha-LA in PCOS
PCOS patients are initially treated with 2 g myo-inositol and 0.2 mg folic acid, two times per day by oral route, for three months.
- Trial name
- NCT03422289
- Testing
- myo-inositol plus folic acid, myo-inositol plus folic acid plus alpha-lactalbumin
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- Lo.Li.Pharma s.r.l
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