Clinical trials: Polycystic Ovary Syndrome
Pregnancy, Pregestational Diabetes
Safety of Metformin in Pregnancy
This study aims to better characterize the risk linked to metformin use during pregnancy, using a prospective multicentric cohort design enabling a large sample size, in evaluating the rate of birth defects after first trimester…
- Conditions
- Pregnancy, Pregestational Diabetes, Polycystic Ovary Syndrom
- Trial name
- NCT02793505
- Testing
- metformin, any drug not known as a major teratogen or major fetotoxicant
- Volunteers
- 950 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Polycystic Ovary Syndrome, Healthy
Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
Women with PCOS suffer from anovulation and, as a result, infertility. Efforts to clinically induce ovulation in these women using follicle stimulating hormone (FSH) administered subcutaneously seemingly requires prolonged…
- Conditions
- Polycystic Ovary Syndrome, Healthy, Anovulation, Hyperandrogenism
- Trial name
- NCT03252223
- Testing
- Recombinant Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Infertility, Polycystic Ovary Syndrome
Treatment of Anovulatory Infertility in PCOS Patients
Clomiphene citrate (CC) and metformin are two effective drugs used to induce ovulation in patients with polycystic ovary syndrome (PCOS), even if it is still unclear which compound between them should be initially administered.
- Conditions
- Infertility, Polycystic Ovary Syndrome, Anovulation
- Trial name
- NCT00471523
- Testing
- Clomiphene citrate, Metformin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University Magna Graecia
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
The Impact of Obstructive Sleep Apnoea in Women With Polycystic Ovary Syndrome.
Women with PCOS and OSA, compared to women with PCOS only, have more severe clinical and biochemical features of PCOS and impaired QoL.
- Trial name
- NCT03065322
- Testing
- To assess risk of OSA
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
PCOS, Hyperinsulinism
Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS
The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers during the oral glucose tolerance…
- Conditions
- PCOS, Hyperinsulinism, Hyperandrogenism, Metabolic Syndrome
- Trial name
- NCT06889454
- Testing
- GLP-1 receptor agonist, Oral contraceptive, Metformin
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- Attikon Hospital
Polycystic Ovary Syndrome
The Effect of Lifestyle Program Women With PCOS
Polycystic Ovary Syndrome (PCOS) is a common hormonal condition affecting women of reproductive age. In addition to physical symptoms such as irregular menstruation, hormonal changes, and changes in body weight, women with PCOS…
- Trial name
- PCOS (NCT07880366)
- Testing
- Lifestyle Modification Program (LMP)
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Polycystic Ovarian Syndrome, Insulin Sensitivity
PED/PEA-15 Protein, PCOS, Obesity, Insulin Sensitivity Indexes, Metformin, Oral Contraceptives
Insulin-resistance plays an important role in polycystic ovary syndrome (PCOS) physiopathology. The phosphoprotein enriched in the diabetes (PED/PEA-15), a 15 kDa protein related to insulin sensitivity, is over-expressed in type…
- Trial name
- NCT00948402
- Testing
- Metformin, oral contraceptive
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Polycystic Ovary Syndrome
AMH for the Identification of PCOM in PCOS Diagnosis
The purpose of this study is to validate the anti-müllerian hormone (AMH) cut-off established and validated in the APHRODITE study, for the determination of PCOM as part of the diagnosis of PCOS, using the Elecsys AMH Plus…
- Trial name
- HARMONIA (NCT05527353)
- Where
- Finland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
PCOS, NAFLD
Lifestyle Changes in PCOS with OSA and NAFLD
Complain of obstructive sleeping apnea and fatty liver is common in PCOS women so lifestyle changes are recommended
- Conditions
- PCOS, NAFLD, OSA
- Trial name
- NCT06591169
- Testing
- diet restriction and exercise, diet restriction
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Polycystic Ovarian Syndrome, Infertility, Female
Spontaneous Reproductive Outcomes After Oral Inositol Supplementation in Infertile Polycystic Ovarian Syndrome Women.
Polycystic ovarian syndrome (PCOS) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (IR), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility.
- Trial name
- IROP-1 (NCT03598374)
- Testing
- Inositol + Folic acid, Folic acid, Regular intercourses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Polycystic Ovarian Syndrome (PCOS)
Assessment of the Impact of Polycystic Ovary Syndrome on Women's Sexuality
This study, titled SexOPK, aims to evaluate the impact of polycystic ovary syndrome (PCOS) on women's sexual health. PCOS is a common endocrine disorder affecting 5-20% of women of reproductive age, often leading to hormonal…
- Trial name
- SexOPK (NCT06887296)
- Testing
- women answer a questionnaire
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Toulouse
Evaluations, Diagnostic Self, Treatment Adherence
Impact of Vitamin D Supplementation on Cardiometabolic Status and Androgen Profile in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of reproductive, endocrine and metabolic functions. Vitamin D has an influence on metabolic and reproductive functions.
- Trial name
- NCT04117750
- Testing
- cholecalciferol (vit D3)
- Where
- Egypt
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Zagazig University
PCOS, Impaired Glucose Tolerance
Research of Intensive Metabolic Intervention Before Pregnancy in PCOS
To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before…
- Trial name
- PCOS (NCT03383068)
- Testing
- Acarbose 100 MG, Exenatide, Orlistat
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Polycystic Ovary Syndrome
Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism
The classic description of polycystic ovary syndrome (PCOS) is that it is a disorder characterized by menstrual irregularity, chronic anovulation, androgen excess, and abnormal gonadotropin secretion.
- Trial name
- BEYAZ-PCOS (NCT01360996)
- Testing
- 3 mg DRSP/20 μg EE
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Woman's
Polycystic Ovarian Syndrome (PCOS), Herbal Medicine
Clinical Investigation of Herbal Formulation and Its Efficacy in Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome (PCO) is a metabolic disorder that afflicts the women of childbearing age. An approximate of 5-10% women are the victim of this disorder.
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Herbal Medicine, Infertility, Metabolic Disorder
- Trial name
- PCOS (NCT07399535)
- Testing
- Herbal Formulation, Metformin XR, Metformin 750 mg and herbal formulation 500 mg
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Jinnah Postgraduate Medical Centre
PCOS
Insulin and Polycystic Ovary Syndrome
Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women.
- Trial name
- NCT00683774
- Testing
- diazoxide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obesity, Hyperlipidemias
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population.
- Conditions
- Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension
- Trial name
- NCT06049420
- Testing
- Lifestyle counseling and coaching
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Polycystic Ovary Syndrome, in Vitro Fertilization
Vitamin D and Pregnancy Outcome in PCOS Patients
This multicenter double-blinded placebo-controlled randomised trial aims to evaluate the effectiveness of vitamin D supplementation prior to IVF on the live birth rate in women with PCOS.
- Trial name
- NCT04082650
- Testing
- vitamin D
- Where
- 2 sites in China
- Volunteers
- 876 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Polycystic Ovary Syndrome, Menopause
Health Risks and Barriers to Management Across the PCOS Lifespan
The overall objective of the proposed pilot project is to explore health literacy and barriers to management of PCOS across the lifespan and determine whether the cardiometabolic risks of PCOS extend beyond menopause.
- Trial name
- HERBS (NCT05769426)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
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