Clinical trials: Polycystic Ovary Syndrome
Infertility
Comparison Between Letrozole and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome.
210 women with clomiphene resistant PCOS will be randomly divided into 3 equal groups using computer generated random numbers. Group 1 will receive FSH, group 2 will have Letrozole and group 3 will act as the control group with…
- Trial name
- FSH (NCT02304107)
- Testing
- FSH, Letrozole
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome
Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine the relationship between lipid-induced inflammation and ovarian androgen secretion in women with polycystic ovary syndrome (PCOS); and to examine the effect of salsalate and polygonum…
- Trial name
- ELI-ROAS (NCT01489319)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Indiana University
Polycystic Ovary Syndrome, Diet Habit
Advanced Glycation End Products and Dietary Intervention in Polycystic Ovary Patients
Recently, the negative effects of advanced glycation end products on the pathophysiology of some diseases have attracted attention.
- Trial name
- NCT05830487
- Testing
- Low AGE diet with reduced energy and fat, Energy and fat-reduced normal diet
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
PCOS
Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting approximately 6-10% of women of reproductive age.
- Trial name
- NACIPCOS (NCT01896492)
- Testing
- NAC
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Infertility, Polycystic Ovarian Syndrome
HRT Versus MOS for Endometrial Preparation Prior to FET in PCOS Patients
Evaluation of endometrial preparation using either hormonal therapy or ovarian stimulation prior to frozen-thawed embryo transfer (FET) in patients with polycystic ovarian syndrome (PCOS)
- Trial name
- NCT02273791
- Testing
- Estradiol valerate, Sequential Clomiphene citrate and Gonadotropin
- Where
- 2 sites in Egypt
- Volunteers
- 126 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome
Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome
Metformin is one of the most commonly prescribed drugs worldwide for the treatment of Type 2 Diabetes. It has been currently used for the treatment of: polycystic ovary syndrome, gestational diabetes, metabolic syndrome and…
- Trial name
- NCT01366391
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Biocinese
Polycystic Ovarian Syndrome, Subfertility
A Comparison of Letrozole and Clomifene Citrate
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies, affecting 5% to 10% of women of reproductive age. Women with PCOS suffer from anovulatory infertility.
- Trial name
- NCT02647424
- Testing
- Letrozole, Clomiphene
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
PCOS
An Integrated Self-Management Intervention for Adolescents With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder, affecting 7%-18% of reproductive-age women. Women with PCOS are at increased risk for a number of adverse physical and mental health outcomes.
- Trial name
- NCT03600337
- Testing
- Working to Optimize Wellness in Tees with PCOS (WOW)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Texas at Austin
Polycystic Ovary Syndrome, Miscarriage
The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether metformin may improve pregnancy rates, and decrease miscarriage rates and complications of pregnancy, such as toxemia and gestational diabetes, in women with polycystic ovary…
- Conditions
- Polycystic Ovary Syndrome, Miscarriage, Infertility, Toxemia
- Trial name
- NCT00994812
- Testing
- metformin
- Where
- 5 sites in Finland
- Volunteers
- 326 people
- Sponsor
- University of Oulu
Polycystic Ovarian Syndrome
Effect of Metformin Therapy on Serum Under-carboxylated Osteocalcin Levels in Hyperandrogenic Lean Polycystic Ovarian Syndrome Women
High ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity. Meformin is an insulin sensitizing agent will be given for these women trying to interfere with the pathophysiology…
- Trial name
- U-C OC IN PCOS (NCT02244567)
- Testing
- Metformin 850 mg twice daily for 3 months, Serum uc-oc, drug
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Polycystic Ovary
Clomiphene Citrate Stair-Step Protocol
A RCT will be conducted to compare the traditional clomiphene citrate regimens for ovulation induction with the stair-step protocol.
- Trial name
- NCT03178500
- Testing
- Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Dysglycemia
Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
PCOS is the most common endocrine disorder of reproductive aged women. In addition to menstrual and endocrine abnormalities, PCOS is characterized by insulin resistance and glycemic dysregulation.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Dysglycemia, Insulin Resistance
- Trial name
- GEMS-PCOS (NCT06050265)
- Testing
- DEXCOM Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Polycystic Ovary Syndrome
The Effect of Therapy Combination in PCOS With Dlbs 3233
The effect of combination therapy dlbs 3233 and clomifen citrate vs clomifen citrate on homa ir, maturation follicle, and menstrual cycle in PCOS cases at Muhammadiyah Asri Medical Center Hospital
- Trial name
- NCT07403201
- Testing
- dlbs 3233 , clomifen citrat
- Where
- Indonesia
- Volunteers
- 90 people
- Sponsor
- Inlacinpenelitian
Study the Relationship Between Insulin Resistance With Hormonal and Ovarian Morphological Characteristics in Patients With Polycystic Ovarian Syndrome
Correlation of Insulin Resistance With Hormonal and Ovarian Morphological Characteristics in Patients With Polycystic Ovarian Syndrome
We designed a study to determine if ovarian volume (OV) and/or follicle number (FN) are independently associated with abnormal metabolic findings in women diagnosed with PCOS.
- Trial name
- NCT05661565
- Testing
- No intervention
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Familial Partial Lipodystrophy
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)
Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/…
- Conditions
- Polycystic Ovary Syndrome, Familial Partial Lipodystrophy, LMNA (LaMin Nuclear A) Related Disorders
- Trial name
- ANDROLIPO (NCT07412028)
- Testing
- Genetic analysis, Biological analysis, imaging test
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polycystic Ovary Syndrome
The Psychological and Social Impact of PCOS
The aim of the study is to assess the association between the quality of life of patients with PCOS and various factors (age, BMI, socio-professional category, delay in diagnostic of PCOS, infertility, hyperandrogenism, parity…
- Trial name
- SPICE (NCT05982236)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
PCO, Induction of Ovulation
Parameters Declaring PCO Infertile Patients Either Sensitive or Resistant to Different Doses of Clomiphene Citrate.
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder seen in 6%-10% of women (Human Reproduction, 2004). It is characterized by polycystic ovaries, anovulatory cycles, and hyperandrogenism.
- Conditions
- PCO, Induction of Ovulation, Clomiphene Citrate
- Trial name
- NCT04887402
- Testing
- Clomiphene Citrate
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
PCOS, Obesity
Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome
The purpose of this study was to determine whether combined treatment with liraglutide and metformin is more effective than metformin as monotherapy in the treatment of obese women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT02483299
- Testing
- Metformin, Glucophage tablets and Victoza
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Polycystic Ovary Syndrome, Vitamin D Deficiency
Association of Vitamin D Status With Metabolic Markers in Adolescents With Polycystic Ovary Syndrome
This prospective cross-sectional case-control study aims to investigate the relationship between serum vitamin D levels, visceral adipose tissue (VAT) thickness, and metabolic parameters in adolescents diagnosed with polycystic…
- Conditions
- Polycystic Ovary Syndrome, Vitamin D Deficiency, Insulin Resistance
- Trial name
- NCT06970821
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal