Clinical trials: Polycystic Ovary Syndrome
Adverse Effects of Medical Drugs
Effects of Isotretinoin on The Gonads and Hirsutism
The investigators consider that there are some rising concerns about the use of isotretinoin by women of reproductive age with depleted ovarian reserve, hence it is important to detect the effect of isotretinoin on ovarian…
- Trial name
- NCT02855138
- Testing
- oral isotretinoin
- Volunteers
- 80 people
- Sponsor
- Kayseri Education and Research Hospital
Polycystic Ovary Syndrome
Spironolactone Plus Metformin in Polycystic Ovary Syndrome
The investigators examined whether a combined therapy with low-dose spironolactone plus metformin is more effective than metformin alone in 52 overweight/obese Polycystic Ovary Syndrome (PCOS) patients.
- Trial name
- NCT01526616
- Testing
- Metformin, Metformin plus Spironolactone
- Volunteers
- 56 people
- Sponsor
- University Magna Graecia
Vitamin D Deficiency, Clomiphene Allergy
Effect of Vitamin D Oral Supplementation in Poly Csytic Ovarian Women Resistant to Clomiphene Citrate
effect of vitamin D oral supplementation in poly csytic ovarian women resistant to clomiphene citrate
- Conditions
- Vitamin D Deficiency, Clomiphene Allergy, Polycystic Ovary Syndrome
- Trial name
- NCT04916925
- Testing
- Vitamin D, Clomid
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- rana alaaeldin aly ibrahim nasr
Polycystic Ovary Syndrome
Transcriptomic Profile of Adipose Tissue Following n-3 Polyunsaturated Fatty Acid (PUFA) Supplementation
Adipose tissue is a central organ involved in mediating metabolic health, and so the investigation of treatments which improve adipose tissue function is warranted.
- Trial name
- NCT01195155
- Testing
- LC n-3 PUFA (fish oil) Supplement
- Where
- 2 sites in Ireland
- Volunteers
- 10 people
- Sponsor
- The Adelaide and Meath Hospital
PCOS (Polycystic Ovary Syndrome), Obese Adolescents
Lean Beef as Part of a Healthy Meal Plan in Adolescents With Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS)
This pilot randomized controlled study will plan to enroll 36 adolescent females with Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS) to evaluate the effectiveness and feasibility of a tailored…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Obese Adolescents, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities, Overweight Adolescents
- Trial name
- Beef+ (NCT07780188)
- Testing
- Beef+
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Texas A&M University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Comparison Between Two Ovulation Induction Therapies and LOD on Clinical Outcomes in CC-Resistant PCOS Women
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting 4-8% of reproductive-aged women and is a leading cause of infertility due to oligo-anovulation (1).
- Trial name
- NCT06486870
- Testing
- Gonadotropin, Letrozole, laparoscopic ovarian drilling
- Where
- Egypt
- Volunteers
- 183 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome
Subcutaneous Adipose Tissue in Cases With Polycystic Ovarian Syndrome
This study aimed to search whether whole body and subcutaneous adipose tissues increase in PCOS patients and whether these tissues are related to HOMA-IR and plasma adiponectin levels.
- Trial name
- NCT01310569
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Polycystic Ovary Syndrome
Probiotic Intervention in PCOS
The investigators are conducting a double-blinded randomized controlled trial to determine whether a probiotic mixture is effective in reducing PCOS-related symptoms.
- Trial name
- ProPCO-RCT (NCT04593459)
- Testing
- Probiotic, Metformin Hydrochloride
- Where
- Austria
- Volunteers
- 112 people
- Sponsor
- Medical University of Graz
Polycystic Ovary Syndrome, Hyperandrogenism
Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility which affects 12-21% of the population.Several studies performed evaluate the possible benefit of metformin alone or in combination with…
- Trial name
- NCT02523898
- Testing
- metformine, clomiphene citrate
- Volunteers
- 388 people
- Sponsor
- Semnan University of Medical Sciences
Weight Loss, Anovulation
Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
The objective of this study is to explore the effects of weight loss on body composition, metabolic status, reproductive hormones, and ovarian follicle development in obese women with regular menstrual cycles versus obese women…
- Conditions
- Weight Loss, Anovulation, Amenorrhea, Infertility
- Trial name
- NCT01785719
- Testing
- Commercial Weight Loss Program
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cornell University
Polycystic Ovary Syndrome, Hyperandrogenism
Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
The purpose of this study is to understand the effects of elevated male hormones in adolescent girls and how they effect the development of polycystic ovary syndrome (PCOS).
- Trial name
- NCT01428193
- Testing
- Flutamide, Progesterone, estrace
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Insulin Resistance
Insulin Resistance Before and During Pregnancy in Women With Polycystic Ovary Syndrome
The polycystic ovary syndrome (PCOS) affects about 10% of reproductive-age women. Women with PCOS are at a higher risk of gestational diabetes, which may lead to more pregnancy complications.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Insulin Sensitivity, Obesity
- Trial name
- NCT01475565
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Ovarian Hyperstimulation Syndrome
Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels < 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at…
- Trial name
- NCT01815138
- Testing
- hCG
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UConn Health
Polycystic Ovary Syndrome, Assisted Reproduction
Mitochondrial DNA in Fresh Versus Frozen Embryo Culture Media of PCOS Women Undergoing In Vitro Fertilization
Ninety women with PCOS candidate for ICSI were randomized to 2 groups:Group A: fresh samples of PCOS patients undergoing IVF (no= 45) and Group B: frozen samples of PCOS patients undergoing IVF (no= 45).
- Trial name
- NCT03820167
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome
Absorption and Tolerability Studies of an Emulsion Containing the Coconut Oil-derived Glycerol Tridecanoate in Healthy Men
The primary aim of the study is to test safety and tolerance of oral intake of GT oil in the form of a non-diary based emulsion (10g of GT per emulsion) in healthy men.
- Trial name
- NCT03255889
- Testing
- Glyceryl Tridecanoate
- Where
- Singapore
- Volunteers
- healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
Efficacy of Canagliflozin Versus Metformin in Women With Polycystic Ovary Syndrome
The goal of this clinical trial is to investigate the use of ultra-high performance liquid chromatography-mass spectrometry for metabolomics and proteomics research in patients with Polycystic Ovary Syndrome (PCOS) and…
- Trial name
- NCT06256289
- Testing
- Canagliflozin 100mg Tab, Metformin Hydrochloride
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ping Li,MD
Polycystic Ovary Syndrome
Novel Subtypes of Polycystic Ovary Syndrome
To classify subtypes of Polycystic Ovary Syndrome (PCOS) using machine-learning algorithms, and compare the reproductive and metabolic characteristics and IVF outcomes across these identified subtypes.
- Trial name
- NCT06124391
- Testing
- Long-term follow-up
- Where
- 11 sites in United States, Brazil and 4 more
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Polycystic Ovary Syndrome
Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)
Women with PCOS suffer from excess male hormone (androgen) production by the ovary. Androgen is made by cells that surround follicles that contain eggs.
- Trial name
- NCT02145247
- Testing
- hCG
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Polycystic Ovary Syndrome
Weight Cycling on Hyperandrogenemia and Insulin Resistance in Polycystic Ovary Syndrome
This study prospectively includes PCOS patients with normal weight and overweight/obesity, closely follows up and intensively manages them, and observes the level and distribution of weight reduction achieved by patients after…
- Trial name
- WHIP (NCT06545721)
- Testing
- Adjusting dietary structure + exercise + behavioral intervention, Precision dietary prescription, Standard guideline-based low-energy diet
- Where
- China
- Volunteers
- 425 people
- Sponsor
- Peking Union Medical College Hospital
PCOS
Vaginal Administration of Metformin in PCOS Patients.
Polycystic ovary syndrome is a common cause of irregular periods, poor ovulation and delay in achieving pregnancy. Certain drugs may help improve ovarian activity in such women as metformin.
- Trial name
- VMPCO (NCT02026869)
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
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