Clinical trials: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome
Insulin resistance is an important feature of the polycystic ovary syndrome,and patiens are successfully treated with the insulin sensitizing agent metformin. The insulin resistance of lean patients with the syndrome is debated.
- Trial name
- NCT00319293
- Testing
- Metformin
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital Skejby
PCOS
OCP vs Metformin on Ovarian Stromal Blood Flow in PCOS
This study is undertaken to compare the effects of treatment with commonly used OCP containing ethinylestradiol-cyproterone acetate and metformin in women with PCOS.
- Trial name
- NCT03236740
- Testing
- Ethinyl Estradiol-cyprosterone acetate, Metformin Hydrochloride
- Where
- India
- Volunteers
- 101 people
- Sponsor
- S.C.B. Medical College and Hospital
Polycystic Ovary Syndrome
Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)
The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water…
- Trial name
- MRI-PCOS (NCT03043924)
- Testing
- Cyproterone Acetate + estradiol, Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Polycystic Ovary Syndrom, Metformin
PCOS Patients' Immune Alterations
In this study, the investigators will include PCOS patients and healthy women who meet the trial criteria from the clinical research centers of 3 hospitals, introduce the content of this study to participants, and invite…
- Conditions
- Polycystic Ovary Syndrom, Metformin, Immune Function
- Trial name
- NCT06325969
- Testing
- Detect the immune function of peripheral blood samples
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Polycystic Ovarian Syndrome, Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome and Cabergoline
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I)…
- Trial name
- NCT01569256
- Testing
- Cabergoline
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
Polycystic Ovarian Syndrome
Endometrial Effects of Metformin Action in Women With Polycystic Ovarian Syndrome (PCOS)
The investigators aim is to conduct a prospective un-blinded pilot study of premenopausal women diagnosed with Polycystic Ovarian Syndrome (PCOS), defined using criteria developed at the 1990 NICHD conference on PCOS, undergoing…
- Trial name
- NCT01070160
- Testing
- Endometrin (progesterone 100mg vaginal inserts), Metformin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Hyperandrogenism, Polycystic Ovary Syndrome
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CBS010 (NCT04723862)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovarian Syndrome
In-Vitro Maturation of Oocytes From Polycystic Ovarian Patients Undergoing IVF
Retrieval of immature oocytes from women with polycystic ovaries, their in-vitro maturation, fertilization and embryo transfer can prevent hormonal treatment that can lead to ovarian hyperstimulation.
- Trial name
- IVM (NCT00561808)
- Testing
- In-vitro maturation oocytes
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Polycystic Ovary Syndrome
Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome
To evaluate the effects of melatonin supplementation on the main in vitro fertilization (IVF) outcomes during ovarian stimulation in patients with Polycystic ovarian syndrome (PCOS).
- Trial name
- NCT01540747
- Testing
- Myo-inositol + folic acid + melatonin, Myo-inositol + folic acid
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Polycystic Ovary Syndrome, Infertility
Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients
Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).
- Conditions
- Polycystic Ovary Syndrome, Infertility, ART
- Trial name
- NCT04268563
- Testing
- metformin, Sitagliptin, Sitagliptin/metformin
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
PCOS and US Cavitation
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Women with this syndrome may have infrequent menstrual periods or amenorrhea and excess androgen levels.
- Trial name
- NCT05880550
- Testing
- ultrasound cavitation in addition to aerobic ex, aerobic exercises.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Obesity, Hyperlipidemias
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population.
- Conditions
- Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension
- Trial name
- NCT06049420
- Testing
- Lifestyle counseling and coaching
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Reproductive System Disorder, Urinary Incontinence
The Effect of Polycystic Ovary Syndrome on Pelvic Floor Structure and Function
Polycystic Ovarian Syndrome (PCOS) is the most common endocrinological disorder in women of reproductive age, and its prevalence is reported to be 6-21% in women aged 15-49 (1).
- Conditions
- Reproductive System Disorder, Urinary Incontinence, Urogenital Disease, Polycystic Ovary Syndrome
- Trial name
- NCT04398186
- Testing
- Anogenital distance measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giresun University
Polycystic Ovarian Syndrome
Myo-inositol Versus Metformin in Patients With Polycystic Ovarian Syndrome to Treat Obesity
There are considerable gaps in the comparative effectiveness and tolerability of myo-inositol and metformin for treating obesity in patients with polycystic ovarian syndrome (PCOS).
- Trial name
- NCT07387679
- Testing
- Myo-inositol, Metformin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Muhammad Aamir Latif
Polycystic Ovary Syndrome (PCOS), Insulin Resistance
PCOS Treatment Using DLBS3233, Metformin, and Combination of Both
This is a 3-arm, randomized, double-blind, double-dummy, and controlled clinical study over 6 months of treatment to evaluate the metabolic and clinical efficacy as well as the safety of DLBS3233 alone, metformin and combination…
- Trial name
- POSITIF (NCT01999686)
- Testing
- DLBS3233, Metformin XR
- Where
- 7 sites in Indonesia
- Volunteers
- 186 people
- Sponsor
- Dexa Medica Group
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome and Exercise
Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder characterized by oligo-ovulatory menstrual dysfunction, androgen excess and polycystic ovaries.
- Trial name
- NCT03362918
- Testing
- High Intensity Interval Training, Continuous Aerobic Exercise Training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Polycystic Ovarian Syndrome
Efficacy Study of Raloxifene to Induce Ovulation in Polycystic Ovarian Syndrome
This study examines Raloxifene versus Clomiphene to induce ovulation in women with polycystic ovarian syndrome (PCOS).
- Trial name
- PCOS (NCT01607320)
- Testing
- Raloxifene, Clomiphene
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Bruce Lessey
Polycystic Ovary Syndrome
Letrozole or Combined Metformin Clomiphene Citrate (CC) for Women With CC Resistant Polycystic Ovary Syndrome
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of combined metformin and Clomiphene in infertile women with polycystic ovary syndrome (PCOS) not responding to treatment with…
- Trial name
- NCT00911313
- Testing
- Letrozole tablets (Femara; Novartis Pharma, Switzerland), metformin HCl (Cidophage®; CID,Cairo, Egypt), CC (Clomid®; Global Napi Pharmaceuticals, Cairo, Egypt)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome
Effects of Pioglitazone on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome (PCOS)
Our hypothesis is that hyperinsulinemia increases the renal clearance of D-chiro-inositol (DCI) in women with polycystic ovary syndrome (PCOS) and that this leads to a reduction in circulating insulin-stimulated…
- Trial name
- PCOS (NCT00868140)
- Testing
- pioglitazone
- Where
- 2 sites in United States, Venezuela
- Volunteers
- 51 people
- Sponsor
- Virginia Commonwealth University
Reproductive Age, PCOS (Polycystic Ovary Syndrome)
Pro- and Anti-inflammatory Cytokines in PCOS
The study will involve measurements and comparisons of the concentrations of pro-inflammatory cytokines: IL-6, TNF-α, IL-18, as well as anti-inflammatory cytokine IL-4 in women with polycystic ovary syndrome (PCOS) and insulin…
- Trial name
- NCT06793085
- Testing
- Measurement of interleukin-6 (il-6) concentration in blood serum, Measurement of fasting tumor necrosis factor α (TNF-α) concentration, Measurement of interleukin-18 (il-18) concentration
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
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