Clinical trials: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome, Metformin
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS
The aim of this study is to see the associations of metabolic responses of metformin with single nucleotide polymorphisms (SNPs) (rs628031 and rs2282143) of solute carrier family 22 member 1 (SLC22A1) gene in women with…
- Trial name
- NCT05680805
- Testing
- Metformin Hydrochloride
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Polycystic Ovary Syndrome, Menstrual Problem
Myoinositol Plus L-tyrosine, Selenium and Chromium in PCOS
PCOS patients were treated every day, with one sachet containing 2000 mg myo-inositol, 500 mg L-tyrosine, 40 mcg chromium picolinate, 55 mcg selenium, 200 mcg folic acid.
- Conditions
- Polycystic Ovary Syndrome, Menstrual Problem, Hirsutism
- Trial name
- NCT03673995
- Testing
- Myo-inositol+L-tyrosine
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Pharmarte srl
Polycystic Ovary Syndrome (PCOS), Metabolic Syndrome
Malay Women With PCOS and Their Association With Metabolic Syndrome
The abnormalities that characterize the Metabolic Syndrome (MetS) confer an increased risk of cardiovascular and other diseases.
- Trial name
- MPMSS (NCT03414957)
- Testing
- Hormonal and biochemical blood tests and ultrasound scanning
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cyberjaya University College of Medical Sciences
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome
Extended-release vs Immediate-release Metformin in PCOS Women
The aim of our study is to compare the different effects of 6 months treatment with extended-release metformin and immediate-release metformin on clinical, endocrine and metabolic parameters in women affected by polycystic ovary…
- Trial name
- NCT02984722
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Catholic University of the Sacred Heart
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Laboratory and Ultrasound Findings and Response to Letrozole in PCOS Patients
The goal of this observational study is to compare laboratory and ultrasound findings between letrozole-resistant and letrozole-sensitive PCOS patients in Egypt.
- Trial name
- NCT06861803
- Testing
- Letrozole tablets
- Where
- Egypt
- Volunteers
- 138 people
- Sponsor
- Al-Azhar University
Polycystic Ovary Syndrome, Infertility
Inositol in Letrozol Resistant PCOS Women
Polycystic ovary syndrome (PCOS),is a complex neuro-endocrine disorder affecting approximately 5% to 10% of women in reproductive age.Inositols are considered insulin sensitizers, as they modulate the members of insulin signaling…
- Trial name
- NCT07585396
- Testing
- Myoinositol, Metformin
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Kafrelsheikh University
Polycystic Ovary Syndrome
The Study of Polycystic Ovary Syndrome (PCOS) and Questionnaire
Polycystic ovary syndrome (PCOS) is an extremely common disorder in women of reproductive age. Diagnosis of PCOS is principally based on clinical and physical findings.
- Trial name
- NCT01256970
- Where
- Taiwan
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Polycystic Ovary Syndrome
Exploring Liver and Muscle Fat Content Using MRI
The aim of our study was to compare the difference of fatty infiltration in liver and muscle using magnetic resonance imaging (MRI) between overweight as well as obese polycystic ovary syndrome (PCOS) cases and body mass index…
- Trial name
- NCT05592080
- Testing
- MRI
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bing He
Polycystic Ovary Syndrome
REFUEL PCOS Study 1
Polycystic Ovary Syndrome (PCOS) affects 10% of all women, and it usually co-exists with high levels of male pattern hormones (also termed androgens).
- Trial name
- REFUEL-PCOS (NCT05973175)
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Depression, Anxiety
Research on Risk Factors and Interventions of Polycystic Ovary Syndrome Complicated With Depression and Anxiety
The current study intends to establish a prediction method and evaluation system for polycystic ovary syndrome (PCOS) complicated with affective disorder, such as depression and anxiety, through the epidemiological investigation.
- Trial name
- PCOS (NCT04984070)
- Testing
- Oral Contraceptives, Combined, Metformin Pill, lifestyle intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
PCOS (Polycystic Ovary Syndrome)
Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot
The SPARK- Pilot study (Symptoms of PCOS Ameliorated by Responses to Keto-adaptation) is a 12-week clinical trial at The Ohio State University designed to explore how different ways of achieving ketosis may improve reproductive…
- Trial name
- (SPARK-Pilot) (NCT07227363)
- Testing
- Ketogenic diet, Exogenous Ketone Supplement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Polycystic Ovary Syndrome (PCOS) Women
Health-related Quality of Life of Women with Polycystic Ovary Syndrome At Sohag University Hospital
It is well-established that PCOS women suffer from anxiety, depression, and markedly reduced QoL ,but There has not yet been a nationally representative study to evaluate the PCOS health related Qol and factors affecting it among…
- Trial name
- NCT06832735
- Where
- Egypt
- Volunteers
- 352 people
- Sponsor
- Sohag University
Polycystic Ovary Syndrome
A Study of Safety and Efficacy of Tildacerfont in Females With Polycystic Ovary Syndrome and Elevated Adrenal Androgens
An investigation of the safety and efficacy of tildacerfont in women with PCOS and elevated adrenal androgens
- Trial name
- NCT05370521
- Testing
- Tildacerfont
- Where
- 21 sites in United States
- Volunteers
- 27 people
- Sponsor
- Spruce Biosciences
Polycystic Ovary Syndrome
Taichi for Overweight/Obese Adolescent and Young Women With Polycystic Ovary Syndrome (PCOS)
The present study is a randomized pilot study, overweight/obese adolescent and young PCOS subjects will be assigned into two groups: Taichi arm and control arm. Hormonal profile and metabolic profile will be determined.
- Trial name
- NCT02608554
- Testing
- Taichi, Self-monitored exercise
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Polycystic Ovary Syndrome
A Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth in Women With PCOS
This study is a randomized assessor-blind controlled trial. A total of 1,103 women with PCOS will be recruited from 20 hospitals and randomly allocated into four groups: personalized acupuncture, fixed acupuncture, letrozole or…
- Trial name
- NCT03625531
- Testing
- Acupuncture, Letrozole
- Where
- China
- Volunteers
- 1,103 people
- Sponsor
- Hongxia Ma
Polycystic Ovary Syndrome, Lipid Metabolism Disorders
Dietary Fish Oil Intervention in Polycystic Ovary Syndrome (PCOS)
The primary objective in this proposed study is to determine the effect of dietary fish oil supplementation compared to standard care metformin treatment, and fish oil in combination with metformin on plasma lipids and…
- Trial name
- PCOS (NCT04116203)
- Testing
- Metformin, Fish Oil and Metformin, Fish Oil
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University of Alberta
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Polycystic Ovary Syndrome (PCOS)
Effect of a Digital Health Education Program on Quality of Life in Women With Polycystic Ovary Syndrome
This single-blind randomized controlled trial evaluated the effectiveness of a digital health education program delivered through WhatsApp in improving the quality of life of women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07684430
- Testing
- Digital Health Education Program, routine care
- Where
- Cyprus
- Volunteers
- 70 people
- Sponsor
- Near East University, Turkey
Vitamin D Receptor Defect
Endometrial Vitamin D Receptor in PCOS
Vitamin D receptor (VDR) is widely expressed not only in tissues responsible for calcium hemostasis, but also in reproductive organs, including the endometrium.
- Trial name
- NCT05885633
- Testing
- endometrial sampling with pipelle
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Uşak University