Clinical trials: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Treatment Benefits of Berberine Supplementation for Women With PCOS
Berberine is a plant alkaloid, reportedly possesses a wide range of pharmacological activities, including anti-obesity and anti-dyslipidemia.
- Trial name
- NCT05480670
- Testing
- Berberine
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Ayub Teaching Hospital
Polycystic Ovary Syndrome
Molecular Basis of PCOS in Oocytes and Surrounding Cells
Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age that is characterized by elevated androgen levels, ovulatory dysfunction and polycystic ovarian morphology (PCOM).
- Trial name
- NCT04493788
- Testing
- Blood test, ultrasound and egg retrieval
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Uric Acid Concentration, Serum, Quantitative Trait Locus 7, Polycystic Ovary Syndrome
Metabolic Differences Between Subtypes of Polycystic Ovary Syndrome
We aimed to investigate serum uric acid levels in patients with different phenotype of policystic ovary syndrome and to compare healthy controls.
- Trial name
- NCT06342180
- Testing
- Serum uric acid level
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Uşak University
Polycystic Ovary Syndrome
Compromised Microcirculation in Women With Polycystic Ovary Syndrome
The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone…
- Trial name
- NCT00757185
- Testing
- ganirelix acetate, methyl testosterone
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome (PCOS)
A Randomized Controlled Trial of Acupuncture for Insulin Resistance in Patients With Polycystic Ovary Syndrome
To determine the efficacy and safety of 2 different treatment modalities: 1) acupuncture plus lifestyle management (treatment group), 2) placebo plus lifestyle management (control group) in the treatment of insulin resistance in…
- Trial name
- NCT06306417
- Testing
- lifestyle intervention, acupuncture
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Polycystic Ovary Syndrome, Anovulation
Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance
- Trial name
- INSUPP-PCOS (NCT03864068)
- Testing
- Inositol
- Where
- 2 sites in United States
- Volunteers
- 154 people
- Sponsor
- Milton S. Hershey Medical Center
Polycystic Ovary Syndrome
Impact of 11-oxygenated Androgens on Metabolic Dysfunction of Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 10% of all women and usually presents with irregular menstrual periods and difficulties conceiving.
- Trial name
- 11OXO-PCOS (NCT05246865)
- Testing
- oral androgen challenge with dehydroepiandrosterone (DHEA)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Infertility
Letrozole Versus Laparoscopic Ovarian Drilling in Polycystic Ovary Syndrome
Polycystic ovary syndrome is the major cause of anovulatory infertility. Clomiphene citrate is the most commonly used oral agent for ovulation induction in this group, but there are some drawbacks with the use of it.
- Trial name
- NCT03009838
- Testing
- Letrozole, ovarian drilling
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome
Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study
Polycystic Ovary Syndrome (PCOS) is very common, affecting approximately 5% of women of reproductive age, and impacts not only on quality of life, but also has long-term health consequences for many sufferers, such as increased…
- Trial name
- REPOS (NCT00746148)
- Testing
- Reflexology
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Nottingham
Polycystic Ovary Syndrome
Research of Intensive Lifestyle Intervention for PCOS Patients With IGT
Compare the efficacy between intensive lifestyle intervention and drugs (GLP-1 Receptor Agonists, metformin and acarbose) for PCOS patients with early onset diabetes in their metabolic and reproductive abnormalities treatment…
- Trial name
- NCT02446834
- Testing
- intensive lifestyle intervention, GLP-1 Receptor Agonists, Metformin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Polycystic Ovary Syndrome
Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome
We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.
- Trial name
- NCT05075863
- Testing
- Letrozole
- Where
- Pakistan
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Nishtar Medical University
Polycystic Ovary Syndrome
Lifestyle Change in Women With Polycystic Ovary Syndrome
This project aims to compare "diet" and "diet and exercise combination" interventions in obese women with polycystic ovary syndrome.
- Trial name
- NCT05377021
- Testing
- Lifestyle change
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients with PCOS (polycystic ovary…
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Polycystic Ovarian Syndrome, GnRH Antagonist
- Trial name
- NCT05326087
- Testing
- GnRH antagonist, MPA
- Volunteers
- 204 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
PCOS (Polycystic Ovary Syndrome)
Optimal Allogeneic PRP Concentration for Oocyte In Vitro Maturation in Women With PCOS
In vitro maturation is a long-studied technique used to obtain mature oocytes outside the human body. However, this method can increase the risk of ovarian hyperstimulation syndrome (OHSS), particularly in patients with…
- Trial name
- NCT07514234
- Testing
- PRP plasma rich platelets
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Gadjah Mada University
Polycystic Ovary Syndrome
The Effect of Escitalopram in PCOS
In a randomized study the investigators aim to characterize the effect of antidepressive medicine on quality of life, body composition, adrenal activity and glucose metabolism in PCOS.
- Trial name
- NCT05840692
- Testing
- Escitalopram 20 mg
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Polycystic Ovary Syndrome
The Experience of Living With Polycystic Ovary Syndrome in the Military
The purpose of this study is to understand the experience of living with polycystic ovary syndrome (PCOS) as an active duty Service Woman.
- Trial name
- PCOS (NCT03876665)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
PCOS
Cavitation Ultrasound in Treatment of Patients With PCOS
The aim of the current work was to compare the efficacy of cavitation ultrasound, metformin or combination of both in obese women with polycystic ovary syndrome (PCOS) regarding clinical pregnancy rate, ovulation rate, insulin…
- Trial name
- NCT01622257
- Testing
- Cavitation US, Metformin, Cavitation US + Metformin
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome
Metformin in Assisted Reproduction-MET-AR-study
Aim of study: To investigate whether four months of metformin treatment before IVF (in-vitro-fertilisation) or ICSI (intra-cytoplasmic-sperm-injection) might increase clinical pregnancy rate in normal-weight (body mass index…
- Trial name
- NCT00159575
- Where
- 2 sites in Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology