Clinical trials: Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome
Cinnamon and COH in PCOS Women Underdoing IVF/ICSI Cycles
In patients with polycystic ovary syndrome, insulin resistance increases, and since the extracts from cinnamon reduces insulin resistance by two mechanisms (1- increasing activation of the IRS/PI-3 kinase insulin signaling…
- Trial name
- NCT06199024
- Testing
- Oral cinnamon supplementation
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Royan Institute
Polycystic Ovary Syndrome, Metformin
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS
The aim of this study is to see the associations of metabolic responses of metformin with single nucleotide polymorphisms (SNPs) (rs628031 and rs2282143) of solute carrier family 22 member 1 (SLC22A1) gene in women with…
- Trial name
- NCT05680805
- Testing
- Metformin Hydrochloride
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Polycystic Ovary Syndrome, Metabolic Syndrome
A Comparison of a PULSE Diet and the TLC Diet on Reproductive, Metabolic Parameters in Women with PCOS
The main objective of the study is to evaluate the effectiveness of a lifestyle program for women with Polycystic Ovary Syndrome (PCOS). The investigators want to assess the efficacy of a pulse-based diet (i.e.
- Trial name
- NCT05428566
- Testing
- Pulse-based diet, TLC diet
- Where
- 2 sites in Jordan
- Volunteers
- 144 people
- Sponsor
- University of Jordan
Polycystic Ovary Syndrome, Infertility
Ovulation Induction in Clomiphene Citrate Resistant PCO Women
Polycystic ovary syndrome (PCOS) affects 5-10% of women in childbearing age. Hyperinsulinemia contributes to chronic anovulation commonly encountered in women with PCOS. The first choice therapy is clomiphene citrate (CC).
- Trial name
- NCT02341703
- Testing
- letrozole-metformin, letrozole-metformin-pioglitazone, transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Overweight and Obesity
Weight Loss Intervention in Women With PCOS
The proposed single arm 6 mo. trial will assess the impact of weight loss and fat loss due to a multicomponent remotely-delivered lifestyle intervention on ovulation rates and time-to-ovulation in overweight and obese women with…
- Trial name
- NCT03677362
- Testing
- Weight loss intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Kansas Medical Center
Infertility Drugs, Infertility Involuntary
Letrozole vs. Clomiphene Citrate Plus Tamoxifen for Ovulation Induction and Pregnancy Outcomes.
Infertility is a common reproductive health problem. Ovulation induction is a key treatment for women with anovulatory infertility. Letrozole and clomiphene citrate are widely used medications for ovulation induction.
- Trial name
- LET-CC-TAM (NCT07616973)
- Testing
- Letrozole, Clomiphene Citrate + Tamoxifen
- Where
- Yemen
- Volunteers
- 240 people
- Sponsor
- Sana'a University
PCOS (Polycystic Ovary Syndrome), Infertility
Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
This randomized clinical trial aims to compare the efficacy and safety of extended letrozole therapy (5 mg/day for 10 days) versus standard letrozole therapy (5 mg/day for 5 days) for ovulation induction in women with polycystic…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Infertility, Anovulation
- Trial name
- PROLEx-PCOS (NCT07159880)
- Testing
- Traditional Letrozole Therapy, Extended Letrozole Therapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GABRIEL MONTEIRO PINHEIRO
Polycystic Ovary Syndrome (PCOS)
Intra-Ovarian PRP Compared With Gonadotropin for Ovarian Response in Letrozole-Resistant PCOS
The goal of this randomized clinical trial is to compare autologous platelet-rich plasma (PRP) with gonadotropin for improving ovarian response in women with letrozole-resistant polycystic ovary syndrome (PCOS).
- Trial name
- NCT07777640
- Testing
- Autologous Platelet-Rich Plasma (PRP), Gonadotropin
- Where
- Bangladesh
- Volunteers
- 50 people
- Sponsor
- Bangladesh Medical University
Polycystic Ovary Syndrome
Combined Metformin and Clomiphene Citrate (CC) or Laparoscopic Ovarian Diathermy for Women With CC Resistant Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to compare and determine the efficacy of combined metformin and Clomiphene citrate administration to that of laparoscopic ovarian diathermy (LOD) in infertile women with Polycystic ovary syndrome…
- Trial name
- NCT00969631
- Testing
- metformin HCl (Cidophage®; CID,Cairo, Egypt), CC (Clomid®; Global Napi Pharmaceuticals,Cairo, Egypt),Cairo, Egypt), Laparoscopic ovarian diathermy (LOD)
- Where
- Egypt
- Volunteers
- 282 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome, Hyperandrogenism
Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Many, but not all, girls with high levels of the male hormone testosterone go on to develop polycystic ovary syndrome (PCOS) as adults.
- Trial name
- NCT01427595
- Testing
- Metformin, Progesterone, estrace
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Weight Loss, Anovulation
Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
The objective of this study is to explore the effects of weight loss on body composition, metabolic status, reproductive hormones, and ovarian follicle development in obese women with regular menstrual cycles versus obese women…
- Conditions
- Weight Loss, Anovulation, Amenorrhea, Infertility
- Trial name
- NCT01785719
- Testing
- Commercial Weight Loss Program
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cornell University
Polycystic Ovary Syndrome, Gingival Inflammation
Impact of PCOS on Periodontal Status of Adolescent and Adult Age Group Women
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, primarily affecting the reproductive system, with substantial collateral negative health effects on metabolic, psychological, and cardiovascular…
- Trial name
- NCT05113030
- Testing
- PERIODONTAL STATUS OF FEMALE PATIENTS WITH PCOS (NEWLY DIAGNOSED) OF ADOLESCENT AGE GROUP WILL BE ASSESSED, PERIODONTAL STATUS OF FEMALE PATIENTS WITH PCOS (NEWLY DIAGNOSED) OF ADULT AGE GROUP WILL BE ASSESSED
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Polycystic Ovary Syndrome, PCO
Effects of HICT and Intermittent Fasting on PCOS
The goal of this randomized controlled trial is to compare the effects of High intensity circuit training, Intermittent Fasting, and their combination on PCOS morphology, Anthropometrics, clinical hyperandrogenism and body image…
- Trial name
- NCT06302166
- Testing
- High Intensity Circuit training (HICT), Intermittent Fasting (IF), Combination of HICT and IF
- Where
- 2 sites in Pakistan
- Volunteers
- 33 people
- Sponsor
- Riphah International University
Polycystic Ovarian Syndrome, Obesity
Post-Prandial Liver Glucose Metabolism in PCOS
The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- PLUM (NCT03041129)
- Testing
- oral glucose tolerance test, MRI of liver
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome (PCOS) Women, Obesity
Semaglutide in Women With Polycystic Ovary Syndrome and Obesity
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that is frequently associated with metabolic features, including obesity.
- Trial name
- NCT06896981
- Testing
- Metformin with Semaglutide
- Where
- Bangladesh
- Volunteers
- 31 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Metabolic Syndrome, Polycystic Ovary Syndrome
Combined Oral Contraceptive Pill and Resistance Starch
This study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of placebo to explore if resistant starch improves…
- Trial name
- COR-PCOS (NCT06852365)
- Testing
- wheat dextrin, Oral Contraceptives, Low-Dose, Maltodextrin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Polycystic Ovarian Syndrome (PCOS)
This Study Aims to Evaluate Whether Milamend's Product Could Improve Hormone Balance in Women Who Suffer From Self-reported PCOS Symptoms.
The rationale for this study is to observe the impact of a consumer-grade commercially available product called Milamend Hormone Balance on quality of life and hormonal health in women with self-reported symptoms associated with…
- Trial name
- NCT07764328
- Testing
- A dietary supplement powder for women
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Mila Mend Inc.
Polycystic Ovary Syndrome
Role of the Ketogenic Diet in Women With PCOS
For the fact of PCOS symptoms could be improved with weight loss and improving insulin resistance, the investigators will do this study to evaluate the role of the ketogenic diet in overweight and obese women with PCOS.
- Trial name
- NCT04175964
- Testing
- ketogenic diet, caloric diet with Metformin, caloric diet
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Polycystic Ovary Syndrome
Effects of Flutamide on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the major cause of infertility in the United States. Many women with PCOS demonstrate insulin resistance and a compensatory hyperinsulinemia.This is due to both an intrinsic form of insulin…
- Trial name
- PCOS (NCT00729560)
- Testing
- Flutamide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Polycystic Ovary Syndrome, Healthy
Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
Women with PCOS suffer from anovulation and, as a result, infertility. Efforts to clinically induce ovulation in these women using follicle stimulating hormone (FSH) administered subcutaneously seemingly requires prolonged…
- Conditions
- Polycystic Ovary Syndrome, Healthy, Anovulation, Hyperandrogenism
- Trial name
- NCT03252223
- Testing
- Recombinant Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
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