Clinical trials: Polycystic Ovary Syndrome (PCOS)
Impaired Glucose Tolerance, Hyperinsulinism
Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes
This study investigated any potential associations between two isocaloric diets with different meal frequency (3 meals versus 6 meals) and glycemic control in people at high diabetes risk (lean and overweight/obese women with…
- Conditions
- Impaired Glucose Tolerance, Hyperinsulinism, Poor Glycemic Control, Hyperglycemia
- Trial name
- NCT02248272
- Testing
- Isocaloric diet with 3 meals, Isocaloric diet with 6 meals
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Meropi Kontogianni
Hyperandrogenism,, Polycystic Ovary Syndrome,
Presentations of Hyperandrogenic Phenotypes in Taiwanese Women
STUDY QUESTION: Which of the four abnormally elevated androgen groups (total testosterone [TT], androstenedione [A4], free androgen index [FAI], or dehydroepiandrosterone-sulfate [DHEA-S]) present with an unfavorable metabolic…
- Conditions
- Hyperandrogenism,, Polycystic Ovary Syndrome,, Metabolic Syndrome,, Insulin Resistance,
- Trial name
- NCT01940666
- Where
- Taiwan
- Volunteers
- 649 people
- Sponsor
- Taipei Medical University WanFang Hospital
Polycystic Ovary Syndrome
Role of the Ketogenic Diet in Women With PCOS
For the fact of PCOS symptoms could be improved with weight loss and improving insulin resistance, the investigators will do this study to evaluate the role of the ketogenic diet in overweight and obese women with PCOS.
- Trial name
- NCT04175964
- Testing
- ketogenic diet, caloric diet with Metformin, caloric diet
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Polycystic Ovary Syndrome
Spironolactone Plus Metformin in Polycystic Ovary Syndrome
The investigators examined whether a combined therapy with low-dose spironolactone plus metformin is more effective than metformin alone in 52 overweight/obese Polycystic Ovary Syndrome (PCOS) patients.
- Trial name
- NCT01526616
- Testing
- Metformin, Metformin plus Spironolactone
- Volunteers
- 56 people
- Sponsor
- University Magna Graecia
PCOS, Insulin Resistance
Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS.
- Trial name
- NCT02766803
- Testing
- Simvastatin and micronized trans-resveratrol
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Insulin Resistance, Polycystic Ovary Syndrome
Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic…
- Conditions
- Insulin Resistance, Polycystic Ovary Syndrome, Hyperinsulinism, Obesity
- Trial name
- DAISY (NCT05950282)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ali Chappell
Polycystic Ovary Syndrome
Clinical Efficacy and Safety of Laparoscopic Sleeve Gastrectomy in Obese Patients With PCOS
This study aims to evaluate the clinical efficacy and safety in obese patients with Polycystic Ovary Syndrome after laparoscopic sleeve gastrectomy.
- Trial name
- NCT05536583
- Testing
- Laparoscopic sleeve Gastrectomy
- Volunteers
- 200 people
- Sponsor
- Shanghai 10th People's Hospital
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome and Exercise
Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder characterized by oligo-ovulatory menstrual dysfunction, androgen excess and polycystic ovaries.
- Trial name
- NCT03362918
- Testing
- High Intensity Interval Training, Continuous Aerobic Exercise Training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Polycystic Ovary Syndrome, Periodontitis
Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis
The Purpose of this study is to assess the correlation between the inflammatory periodontal status and the medical treatment status in Polycystic Ovary Syndrome(PCOS) women with systemic inflammation and to evaluate the effect of…
- Conditions
- Polycystic Ovary Syndrome, Periodontitis, Insulin Resistance
- Trial name
- NCT02633462
- Testing
- scaling and root planing , Myo-inositol, Myo-inositol
- Volunteers
- 56 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Polycystic Ovary Syndrome
Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility and causes menstrual disruption in 6.6-6.8% of women in reproductive age and is characterized by insulin resistance, hyperinsulinemia…
- Trial name
- NCT01474967
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Hormozgan University of Medical Sciences
PCOS, Overweight
Effects of Acupuncture on Body Mass Index in Overweight and Obese Women With Polycystic Ovary Syndrome (PCOS )
This is a cross-sectional case-control study combined with a randomised controlled trial (RCT) study. This study aims to compare the effect of acupuncture, with usual care (lifestyle management) for weight control, with BMI (Body…
- Conditions
- PCOS, Overweight, Obesity
- Trial name
- PCOS (NCT04193371)
- Testing
- Active acupuncture, Lifestyle management
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Peking University Third Hospital
PCOS, Obesity
PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome
The purpose of this study was to determine whether combined treatment with phosphodiesterase-4 (PDE-4) inhibitor roflumilast and metformin is more effective than metformin as monotherapy in the treatment of obese women with…
- Trial name
- NCT02037672
- Testing
- metformin, metformin and roflumilast
- Where
- Slovenia
- Volunteers
- 36 people
- Sponsor
- University Medical Centre Ljubljana
PCOS
Comparing the Effects of Oral Contraceptive Pills Versus Metformin
To determine the effect of Oral Contraceptive Pills (OCP) verses Metformin verses OCP and Metformin on the prevalence of Metabolic Syndrome (MetS) and its components in overweight/obese women with Polycystic Ovary Syndrome…
- Trial name
- COMET-PCOS (NCT03229057)
- Testing
- OCP + Metformin
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Anuja Dokras
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Pancreatic Disease
Efficay of Physical Activity Program in PCOS Females With Fatty Pancrease and Thyroid Hypofunction
females of polycystic ovary syndromes may complain fatty pancreaetic disorder and thyroid hypofunctions (subclinical hypothyroidism)
- Conditions
- Polycystic Ovary Syndrome, Non-Alcoholic Fatty Pancreatic Disease, Subclinical hypothyroïdism
- Trial name
- NCT07591246
- Testing
- physical exercise program, usual care
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Insulin Resistance
Metformin vs Inositol vs Diet vs Combination Therapy in PCOS
Polycystic ovary syndrome (PCOS) is a common condition that can cause irregular periods, excess male-type hormones, weight gain, and insulin resistance.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Metabolic Syndrome
- Trial name
- PCOS-COMBO (9) (NCT07380841)
- Testing
- Metformin Hydrochloride, Myo-Inositol, Dietary Restriction
- Where
- Pakistan
- Volunteers
- 192 people
- Sponsor
- Islamabad Medical and Dental College
PCOS (Polycystic Ovary Syndrome)
Feasibility Effects of a Low-GI, High-fibre Diet in PCOS: a Prospective Cohort Study in Remote Yunnan
This study aims to observe the effects of a 6-month, culturally-adapted low glycemic index-high fiber (LGI-HF) dietary on IR, androgen levels, and menstrual regularity among women with PCOS in remote areas of Yunnan Province.
- Trial name
- NCT07426146
- Testing
- low glycemic index-high fiber
- Where
- 2 sites in China
- Volunteers
- 56 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Comparison Between Two Ovulation Induction Therapies and LOD on Clinical Outcomes in CC-Resistant PCOS Women
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting 4-8% of reproductive-aged women and is a leading cause of infertility due to oligo-anovulation (1).
- Trial name
- NCT06486870
- Testing
- Gonadotropin, Letrozole, laparoscopic ovarian drilling
- Where
- Egypt
- Volunteers
- 183 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome (PCOS)
Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS
This cross-sectional study aims to compare the effectiveness of oral contraceptives, oral progesterone (didrogesterone), and inositol in regulating menstrual cycles among women diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07242131
- Testing
- Combined Oral Contraceptive (Ethinylestradiol 0.03 mg + Drospirenone 3 mg), Inositol mid-level volume, Dydrogesterone Pill
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
IVF, Oocyte Maturation Defect 1
IVF Outcome Following Progestogen Ovarian Stimulation
The new strategy is by using the progestogen to block the luteinizing hormone(LH) surge either endogenous during luteal phase stimulation, or exogenous in the follicular phase i.e progestin primed ovarian stimulation (PPOS).
- Conditions
- IVF, Oocyte Maturation Defect 1, Clinical Pregnancy Rate, Ovarian Hyperstimulation
- Trial name
- NCT04175990
- Testing
- Dydrogesterone Pill
- Where
- Malaysia
- Volunteers
- 155 people
- Sponsor
- National University of Malaysia
Poly Cystic Ovary Syndrome
Efficacy of Metformin With and Without Probiotics in Women With PCOS
This prospective interventional study evaluated the effectiveness of metformin alone compared with metformin combined with probiotics in women with polycystic ovary syndrome (PCOS).
- Trial name
- MEP-PCOS (NCT07874646)
- Testing
- Metformin, Probiotics
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Dhivyaprasath Palaniappan
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