Clinical trials: Polycystic Ovary Syndrome (PCOS)
PCOS
A Metabolomic Study of Polycystic Ovary Syndrome With Insulin Resistance and Its Relationship With TCM Syndrome Types
The type-2 diabetes mellitus（T2DM）, metabolic syndrome, cardiovascular disease complications induced by polycystic ovary syndrome(PCOS) with insulin resistance(IR）, which become serious threat to public health.
- Trial name
- NCT02992093
- Testing
- all the indicators
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Polycystic Ovary Syndrome
Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome
PCOS-RCE is an observational, cross-sectional, two-arm study that is aimed at determining if an established diagnosis of polycystic ovarian syndrome (PCOS) influences the number of blood vessel-forming stem cells in the…
- Trial name
- PCOS-RCE (NCT05410834)
- Where
- 3 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Insulin Sensitizers Role in Control of PCOS Vicious Cycle.
PCOS is a common and complex disease affecting women of reproductive age. It is characterized by its complex pathological symptoms and mechanisms resulting in endocrine and metabolic dysfunction.
- Trial name
- NCT06170463
- Testing
- Metformin Hydrochloride, MI/DCI combination in 40:1 ratio, Combination of Metformin hydrochloride and MI/DCI
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Zagazig University
Polycystic Ovary Syndrome, Insulin Resistance
The RCT of Acupuncture on PCOS Combined With IR
The objectives of this randomized controlled trial are to compare insulin sensitivity following true acupuncture + placebo metformin (Group 1) vs sham acupuncture + placebo metformin (Group 2) vs sham acupuncture + metformin…
- Trial name
- NCT02491333
- Testing
- true acupuncture, metformin
- Where
- China
- Volunteers
- 342 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Polycystic Ovary Syndrome
The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients
The study aims to evaluate the effects of combination of metformin with NAC in PCOS on biochemical and hormonal parameters.
- Trial name
- PCOS (NCT06836128)
- Testing
- N-acetyl cysteine, Metfomin
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Cairo University
Insulin Resistance
Brain Metabolism in Polycystic Ovary Syndrome
The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu).
- Trial name
- NCT02409914
- Volunteers
- 7 people
- Sponsor
- Université de Sherbrooke
Infertility, Polycystic Ovary Syndrome
GnRH Antagonist Versus GnRH Agonist in Polycystic Ovary Syndrome During in Vitro Fertilization - Embryo Transfer
GnRH (Gonadotropin-releasing hormone) antagonists in IVF (in vitro fertilization) has been accomplished by several randomized controlled trials compared with conventional GnRH agonist long protocol in polycystic ovary syndrome…
- Trial name
- NCT01402336
- Testing
- GnRH antagonist (Cetrorelix), Conventional GnRH agonist (Triptorelin)
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Polycystic Ovary Syndrome
hMG or Recombinant FSH on OHSS Prevention in PCOS Patients Undergoing IVF
There have been some controversies regarding the use of preparations with LH activity in patients with polycystic ovary syndrome (PCOS) who have high endogenous LH activity.
- Trial name
- NCT01365936
- Testing
- HMG, rFSH
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Ovary Cyst, Fertility Issues
Dydrogesterone-Primed Ovarian Stimulation Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in ICSI
GnRH antagonist protocol is currently a good strategy for controlled ovarian stimulation in women with PCOS undergoing IVF/ICSI cycles.
- Trial name
- NCT05751681
- Testing
- progestin primed ovarian stimulation protocol, dydrogesterone (Duphaston, Abbott), Cetrotide
- Where
- Egypt
- Volunteers
- 79 people
- Sponsor
- Zagazig University
Polycystic Ovary Syndrome
Evaluation of the Effect of Time-Restricted Feeding and Mediterranean Diet Model in Women With Polycystic Ovary Syndrome
Currently, there is still insufficient data to support the long-term efficacy, safety, and health benefits of time-restricted feeding models in women diagnosed with Polycystic ovary syndrome (PCOS), and further studies are needed…
- Trial name
- PCOS (NCT07385716)
- Testing
- Mediterranean diet, intermittent fasting
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Selcuk University
Reproductive Age, PCOS (Polycystic Ovary Syndrome)
Functional Proteins in Polycystic Ovary Syndrome
The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without…
- Trial name
- NCT06793098
- Testing
- Measurement of kisspeptin concentration, Measurement of ghrelin concentration, Measurement of zonulin concentration
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Polycystic Ovary Syndrome
Comparison Between Mediterranean Diet and High Protein Diet in Women With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) affects 5-10% of women and is the most common endocrine syndrome.PCOS is associated with infertility, risk for obesity and type 2 diabetes.
- Trial name
- NCT01615848
- Testing
- mediterranean diet restricted calorie, high protein diet
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Infertility
The Influence of AMH on Ovarian Responsiveness to Ovulation Induction With GnRH in Women With PCOS
The investigator suggests that PCOS women with high AMH levels are resistant to ovarian stimulation and may need adjustment of the dose of gonadotrophin.
- Trial name
- NCT02673632
- Testing
- Merional ®
- Volunteers
- 30 people
- Sponsor
- Ain Shams Maternity Hospital
Polycystic Ovary Syndrome, Obesity
The Effect of a Liraglutide on IVF in Obese PCOS
The aim of this study was to evaluate the impact of low dose liraglutide in combination with metformin compared to metformin alone on IVF pregnancy rate (PR) and cumulatively PR (IVF and spontaneous) in infertile obese women with…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT03353948
- Testing
- MET, COMBI
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Polycystic Ovary Syndrome
Multidisciplinary Diagnosis and Treatment of Polycystic Ovary Syndrome
The investigators collected clinical data and serum samples of patients with polycystic ovary syndrome (PCOS) in this study, used statistical software such as SPSS for date analysis, and used experimental techniques such as ELISA…
- Trial name
- NCT06047574
- Testing
- This study does not involve any interventions
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Shanghai 10th People's Hospital
Menorrhagia, Endometrial Neoplasms
Evaluation of the Goldstein SonoBiopsy™ Catheter for Diagnosing Endometrial Pathology
To assess the adequacy of an endometrial biopsy sample obtained using sonohysterography.
- Conditions
- Menorrhagia, Endometrial Neoplasms, Polycystic Ovary Syndrome, Uterine Neoplasms
- Trial name
- NCT01969396
- Testing
- SonoBiopsy Catheter, Endometrial biopsy catheter
- Where
- Panama
- Volunteers
- 2 people
- Sponsor
- Cook Group Incorporated
Endocrine System Diseases, Gonadal Disorders
Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome
The purpose of this study is to compare the effectiveness of low dose human chorionic gonadotropin (HCG) in combination with clomiphen citrate to induce ovulation and its endocrine response in patients who had previously failed…
- Trial name
- NCT00947713
- Testing
- low dose human chorionic gonadotropin, Clomiphen citrate plus HMG
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Polycystic Ovary Syndrome (PCOS)
Mechanism of Red Yeast Rice Regulating Intestinal Indole Metabolism Pathway to Improve Chronic Inflammation in Polycystic Ovary Syndrome
The aim of this study is to elucidate the effects of red yeast rice on the improvement of symptoms in patients with polycystic ovary syndrome（PCOS）, and to analyze the dose-response relationship between intestinal microbiota and…
- Trial name
- NCT07106996
- Testing
- red yeast rice，RYR
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sichuan Provincial People's Hospital
Polycystic Ovary Syndrome, Metformin
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS
The aim of this study is to see the associations of metabolic responses of metformin with single nucleotide polymorphisms (SNPs) (rs628031 and rs2282143) of solute carrier family 22 member 1 (SLC22A1) gene in women with…
- Trial name
- NCT05680805
- Testing
- Metformin Hydrochloride
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Polycystic Ovary Syndrome
Study to Assess the Effect of Metformin Supplementation on IVF Outcome in Patients With Polycystic Ovarian Syndrome.
This study was performed to investigate the effects of metformin on controlled ovarian stimulation (COS), in vitro fertilization (IVF) outcomes, pregnancy outcomes, and comparison of serum and follicular fluid cytokines and…
- Trial name
- NCT03086005
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Chung-Hoon Kim
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