Clinical trials: Polycystic Ovary Syndrome (PCOS)
Polycystic Ovaries
Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS
Prospective study conducted on 150 women with polycystic ovarian syndrome (PCOS) were randomly divided into 3 groups: group I (50 women) received clomiphene citrate (CC) only 50 mg orally every 8 hours started from cycle day 3…
- Trial name
- PCOS (NCT02352597)
- Testing
- phytoestrogen, estradiol valerate, clomiphene citrate
- Volunteers
- 150 people
- Sponsor
- Cairo University
PCOS, NAFLD
Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome
This study was planned to examine the prevalence of vitamin D insufficiency, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and their relationship with each other and the nutritional status of individuals with…
- Trial name
- NCT05843955
- Testing
- Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Hacettepe University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary Syndrome
This study will investigate whether the addition of Quercetin or Alpha-Lipoic Acid (ALA) to standard metformin therapy can improve symptoms, hormone levels, metabolic health, and quality of life in women with polycystic ovary…
- Trial name
- NCT07182526
- Testing
- Quercetin, Alpha Lipoic Acid 600 MG Oral Tablet, MetFORMIN 500 Mg Oral Tablet
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Mustansiriyah University
Polycystic Ovary Syndrome (PCOS)
Intra-Ovarian PRP Compared With Gonadotropin for Ovarian Response in Letrozole-Resistant PCOS
The goal of this randomized clinical trial is to compare autologous platelet-rich plasma (PRP) with gonadotropin for improving ovarian response in women with letrozole-resistant polycystic ovary syndrome (PCOS).
- Trial name
- NCT07777640
- Testing
- Autologous Platelet-Rich Plasma (PRP), Gonadotropin
- Where
- Bangladesh
- Volunteers
- 50 people
- Sponsor
- Bangladesh Medical University
Polycystic Ovarian Syndrome
Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels
Flax seed oil, fish oil, and soy bean oil, are commonly recommended supplements for Polycystic Ovarian Syndrome (PCOS). These oils have different chemical structures and biological actions.
- Trial name
- PCOS (NCT00579540)
- Testing
- Flax Seed Oil, Fish Oil, Soybean Oil
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Davis
Polycystic Ovary Syndrome, Insulin Resistance
MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome
The aim of this study is to explore the microRNA profile in serum of women with Polycystic Ovary Syndrome and investigate the correlation between the microRNA profile and markers of metabolic syndrome.
- Trial name
- NCT03142633
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Holbaek Sygehus
PCOS, Polycystic Ovary Syndrome
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS.
- Trial name
- CRM010 (NCT04597099)
- Testing
- Micronized progesterone, Flutamide, Estradiol patch
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Non-alcoholic Fatty Liver Disease in Women With PCOS
Saroglitazar Magnesium 4 mg in the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in Women With PCOS (EVIDENCES VII)
This is a multicenter, phase 2A, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of Saroglitazar Magnesium in women with well characterized PCOS.
- Trial name
- NCT03617263
- Testing
- Saroglitazar Magnesium 4 mg Tablet
- Where
- 19 sites in United States, Mexico
- Volunteers
- 60 people
- Sponsor
- Zydus Therapeutics Inc.
Polycystic Ovary Syndrome
Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial.
The purpose of this study is to compare effects of statins (simvastatin) and metformin on clinical (menstrual cycle, excessive hair, skin problems), endocrine (androgens), metabolic (lipids, markers of systemic inflammation), and…
- Trial name
- NCT00396513
- Testing
- Simvastatin, Simvastatin and Metformin, Metformin
- Where
- Poland
- Sponsor
- Poznan University of Medical Sciences
Polycystic Ovary Syndrome (PCOS), Polycystic Ovary Syndrome
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for PCOS
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously for the treatment of Polycystic Ovary Syndrome.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Polycystic Ovary Syndrome, PCOS
- Trial name
- NCT06143527
- Testing
- Cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Insulin Resistance, Polycystic Ovary Syndrome
Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic…
- Conditions
- Insulin Resistance, Polycystic Ovary Syndrome, Hyperinsulinism, Obesity
- Trial name
- DAISY (NCT05950282)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ali Chappell
Polycystic Ovary Syndrome
Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome
Insulin resistance is an important feature of the polycystic ovary syndrome,and patiens are successfully treated with the insulin sensitizing agent metformin. The insulin resistance of lean patients with the syndrome is debated.
- Trial name
- NCT00319293
- Testing
- Metformin
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital Skejby
Polycystic Ovary Syndrome
Effect of Nicotinic Acid on Cardiovascular Risks Indices in Polycystic Ovary Syndrome
Niacin will improve postprandial hyperlipidaemia and cardiovascular risks indices via its lipid lowering as well as via pleiotropic effects in patients with polycystic ovary syndrome (PCOS).
- Trial name
- NCT01118598
- Testing
- tredaptive (nicotinic acid/ laropiprant)
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Polycystic Ovary Syndrome, Hyperinsulinism
Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome
OBJECTIVES: I. Determine whether reduction of serum insulin levels by metformin increases ovulatory response to clomiphene citrate in women with polycystic ovary syndrome.
- Trial name
- NCT00005104
- Testing
- clomiphene citrate, metformin
- Where
- 6 sites in United States, Italy
- Volunteers
- 99 people
- Sponsor
- National Center for Research Resources (NCRR)
Hyperandrogenemia, Polycystic Ovary Syndrome
Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- Trial name
- JCM026 (NCT01428245)
- Testing
- Progesterone, Estrace (estrogen)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Metabolic Syndrome, Polycystic Ovary Syndrome
Evaluation of Licorice Root on Metabolic Syndrome in Polycystic Ovary Syndrome Females
The goal of this study is to learn about the effect of licorice root powder on parameters of metabolic syndrome in those women diagnosed with PCOS with age range of 15-49 years of age.
- Trial name
- NCT06043375
- Testing
- Licorice Root Powder Capsule
- Where
- Pakistan
- Volunteers
- 55 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Polycystic Ovary Syndrome, Anovulation
LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents
PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound .
- Trial name
- NCT04325295
- Testing
- Laparoscopic ovarian drilling, Recombinant FSH (rFSH)
- Volunteers
- 200 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome
Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy
The purpose of this study is to investigate the effect of semaglutide in women with Polycystic Ovarian Syndrome(PCOS ) and determine potential therapeutic benefits.
- Trial name
- NCT06222437
- Testing
- Semaglutide
- Sponsor
- Methodist Health System
Polycystic Ovary Syndrome
Trial With Metformin in Women With Polycystic Ovary Syndrome
The investigators wanted to elucidate the effects of metformin in Polycystic Ovary Syndrome (PCOS) by performing a randomized, double-blinded, placebo-controlled cross-over study.
- Trial name
- NCT02280057
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Herning Hospital
Hyperandrogenemia, Obesity
Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess
Short term hydrocortisone to test whether improves excess androgen production from adrenal gland and ovaries
- Conditions
- Hyperandrogenemia, Obesity, Polycystic Ovary Syndrome
- Trial name
- NCT01422707
- Testing
- Hydrocortisone
- Where
- United States
- Sponsor
- University of Virginia
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