Clinical trials: Polyethylene Glycols
Colorectal Cancer, Colonoscopy
Fixed Low-dose Simethicone Combined With Macrogol 4000 (PEG) Reduces Colon Bubble Formation in Colonoscopy
Several randomised studies have shown that the addition of low-dose Simethicone to the bowel preparation was sufficient to reduce the presence of bubbles during colonoscopy.
- Conditions
- Colorectal Cancer, Colonoscopy, Bowel Preparation Solution
- Trial name
- XIMEPEG-RL (NCT06319924)
- Testing
- Simethicone combined with Macrogol 4000 (PEG)
- Where
- 5 sites in France
- Volunteers
- 601 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Colon Adenoma, Colonic Polyp
Comparison Between a 1L of Polyethylene Glycol+Ascorbic Acid as a Split Dose Bowel Preparation for Colonoscopy
Comparison between a 1L of polyethylene glycol+ascorbic acid as a split dose and oral sulfate solution bowel preparation for colonoscopy study design: prospective, randomized, parallel, multi-center trial in 3 hospitals in Korea…
- Trial name
- NCT04758156
- Testing
- CleanViewAL, SUPREP
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colon Prep for Colonoscopy
Safety and Efficacy Study of an Edible Colonoscopy Preparation
The purpose of this study is to evaluate the efficacy and safety of ECP (PEG 3350) Colon Prep Kit compared with MoviPrep split-dose as a colon-cleansing preparation for colonoscopy.
- Trial name
- NCT03332485
- Testing
- ECP Colon Prep Kit, MoviPrep®
- Where
- 8 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sebela Pharmaceuticals Development LLC
Bowel Preparation, Bowel Preparation for Colonoscopy
A Study to Investigate the Effect of a Meal At 6pm the Day Before the Colonoscopy on the Bowel Cleansing with Plenvu
Bowel cleansing prior to colonoscopy is crucial to be able to perform a high-quality examination. Therefore maximum efforts are made to achieve optimal bowel cleansing including diet restriction and refraining from day-before…
- Conditions
- Bowel Preparation, Bowel Preparation for Colonoscopy, Bowel Cleansing for Colonoscopy, Healthy
- Trial name
- DinNER1006 (NCT06651398)
- Testing
- Lenient diet
- Where
- Belgium
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lactulose, Polyethylene Glycol
Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults
Colonoscopy is the gold standard in bowel assessment when there is suspicion of colon and rectum pathology. Bowel cleansing is necessary to ensure an optimal visualization of colonic mucosa, allowing this form of detection and…
- Conditions
- Lactulose, Polyethylene Glycol, Bowel Preparation, Colonoscopy
- Trial name
- NCT05726344
- Testing
- Lactulose, Polyethylene Glycol 3350
- Where
- Uruguay
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Anemia
An Observational Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) in Stage V Chronic Kidney Disease Participants on Hemodialysis
This observational study will evaluate the efficacy and use of Methoxy polyethylene glycol-epoetin beta (Mircera) in participants with Stage V chronic kidney disease on hemodialysis receiving an erythropoietin prior to study…
- Trial name
- NCT01940484
- Testing
- Methoxy polyethylene glycol epoetin beta
- Where
- 10 sites in South Africa
- Volunteers
- 98 people
- Sponsor
- Hoffmann-La Roche
Patients Undergoing Elective Colonoscopy
Comparison of Bowel Cleansing Regimens Prior to Colonoscopy
The purpose of this study is to to compare two bowel preparation regimens of patients who will undergo colonoscopy, in terms of quality of bowel preparation and in terms of patient satisfaction.
- Trial name
- PRECOL2011-1 (NCT01649674)
- Testing
- polyethylene glycole (PEG) solution, sodium picosulphate and magnesium citrate solution
- Where
- 7 sites in Italy
- Volunteers
- 525 people
- Sponsor
- National Cancer Institute, Naples
Postoperative Adhesion, Peritoneal Adhesion, Nos
Efficacy of Sprayable PEG Barrier in Gynecologic Laparoscopy
The purpose of the study is to investigate whether sprayable PEG barrier is effective in reducing adhesions in laparoscopic gynecologic surgery.
- Trial name
- NCT01187680
- Testing
- Spraygel, Control
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Hyponatremia
Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS
Objective: To compare the incidence of peri-colonoscopy hyponatremia associated with PEG 3350 + sports drink (PEG-SD) versus PEG 3350-electrolyte solution + sodium sulfate + sodium ascorbate and ascorbic acid (PEG-ELS).
- Trial name
- NCT01299779
- Testing
- PEG-SD, PEG-ELS
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Thomas Jefferson University
HIV Infections
Safety and Efficacy of Polyethylene Glycolated IL-2 (PEG IL-2) Plus Zidovudine or Dideoxyinosine in HIV Positive, Asymptomatic and Symptomatic Individuals
To investigate the safety of polyethylene glycolated interleukin-2 (PEG IL-2) given subcutaneously in conjunction with antiviral treatment and to explore the effects of treatment on surrogate markers of efficacy and incidence of…
- Trial name
- NCT00001997
- Testing
- Interleukin-2, Polyethylene Glycolated, Zidovudine, Didanosine
- Where
- United States
- Sponsor
- Chiron Corporation
Colonoscopy
Comparison Between OSS and 2L PEG/Asc for Bowel Preparation of Elderly People
For evaluation of the usefulness of oral sulfate solution (OSS) for bowel preparation of elderly people, investigators compare the efficacy, tolerability and safety between OSS and 2L polyethylene glycol (PEG) with ascorbic acid…
- Trial name
- NCT03520361
- Testing
- Oral sulfate solution (OSS), 2L PEG/Asc
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- KangWon National University Hospital
Chronic Constipation
Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
This study aim was to evaluate the effect of pharmacological treatments normally used to treat functional constipation and in particular PEG, bisacodyl and prucalopride on colonic motility as assessed by high-resolution manometry.
- Trial name
- NCT03279341
- Testing
- polyethylene glycol, Bisacodyl, Prucalopride
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Bowel Preparation
Comparison of Split-dose and Single-dose Bowel Preparation Regimens Using Polyethylene Glycol Electrolyte(PEG)
The goal of this quasi-experimental study was to compare the effect of single-dose and split-dose 3L compound polyethylene glycol electrolyte powder (PEG) regimen on the quality, comfort and tolerability of bowel preparation in…
- Trial name
- PEG (NCT06551883)
- Testing
- different bowel preparation regime, traditional bowel preparation regime
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Tongji Hospital
Colonoscopy
Comparison of Same-day 2 Sachets Picosulfate Versus High Volume PEG for Afternoon Colonoscopy
Comparison of using the same-day 2 sachets picosulfate versus high volume PEG bowel preparation for afternoon colonoscopy Morning only same-day 2 sachets picosulfate may enhance patient tolerability and have similar bowel…
- Trial name
- SP2HP (NCT01685970)
- Testing
- High volume split-dose PEG, 2 sachets of picosulfate
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Inje University
Colo-rectal Cancer, Colonic Neoplasms
Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting
Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority.
- Trial name
- NCT03816774
- Testing
- PEG split-dose and simethicone
- Where
- Portugal
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Multiple Mieloma
Maintenance Treatment of Multiple Myeloma (MM) After Autologous Peripheral Blood Transplant (PBSCT) Using Polyethylene Glycol alpha2B Interpheron (PEG-INTRON)
Multiple myeloma accounts for approximately 1% of all cancers and 10% of hematologic malignancies. Between 50 and 70% of symptomatic patients presented response to induction chemotherapy.
- Trial name
- NCT01325896
- Testing
- PEG-Intron sc injection
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Bowel Preparation, Colonoscopy
Impact of Time Intervals of Preparation on Quality and Tolerance of the Bowel Preparation
The purpose of this study is to determine optimal time intervals for preparation before colonoscopy using different formulas.
- Trial name
- NCT02908919
- Testing
- Colonoscopy
- Where
- 2 sites in Czechia
- Volunteers
- 480 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Colorectal Cancer
Comparison of Mechanical Bowel Preparation Versus Enema for Candidates to Colorectal Resection for Adenocarcinoma
The purpose of this study is to evaluate mechanical bowel preparation (MBP) with polyethylene glycol plus bowel enema versus bowel enema alone in patients candidates to colorectal resection for malignancy.
- Trial name
- MBP (NCT00940030)
- Testing
- mechanical bowel preparation, enema
- Where
- Italy
- Volunteers
- 440 people
- Sponsor
- European Institute of Oncology
Colonoscopy
Investigation of PICOPREP and PEG-ELS for Bowel Preparation for Colonoscopy
Eligible subjects undergoing a colonoscopy will randomly receive either PICOPREP or polyethylene glycol 4000 electrolyte lavage solution before the procedure to evaluate its effectiveness, tolerability and safety.
- Trial name
- NCT01356407
- Testing
- PICOPREP, PEG-ELS
- Where
- 7 sites in China
- Volunteers
- 300 people
- Sponsor
- Ferring Pharmaceuticals
Bowel Preparation Solutions
Comparison of Clenpiq vs Golytely Bowel Preparation
This is a prospective randomized study which will be done at main campus Cleveland Clinic. The investigators will be comparing the colon cleansing by the Boston Bowel Preparation Scale in participants undergoing colonoscopy as an…
- Trial name
- NCT03198221
- Testing
- Golytely, Clenpiq
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The Cleveland Clinic