Clinical trials: Polyethylene Glycols
Slow Transit Constipation, Pharmacotherapy
Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation
Lubiprostone has established efficacy and a favorable safety profile in chronic constipation and irritable bowel syndrome with constipation (IBS-C).
- Trial name
- STOPS 03 (NCT07277907)
- Testing
- Lubiprostone, Polyethylene glycol (PEG )
- Where
- 20 sites in China
- Volunteers
- 346 people
- Sponsor
- Third Military Medical University
Colonoscopy, Colon Neoplasm
A Prospective Single-Blinded Randomized Trial Comparing Colonoscopic Preparation at Different Time
Colorectal cancer (CRC) is the leading cause of cancer death not only in the Western countries but also in Taiwan. Colonoscopy is now gradually accepted as one of the powerful tool for colorectal cancer screening.
- Trial name
- NCT00155415
- Testing
- Different timing of taking polyethylene glycol(PEG)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Bowel Preparation Solution, Colonoscopy
Comparison of Bowel Preparation Using 2 Liter Polyethylene Glycol Regimen Plus Elobixibat Versus 4-Liter Polyethylene Glycol Regimen
Comparison of bowel preparation using 2 liter polyethylene glycol regimen plus elobixibat Versus 4-Liter polyethylene glycol regimen.
- Trial name
- NCT06436833
- Testing
- 2-Liter polyethylene glycol plus elobixibat, 4-Liter polyethylene glycol
- Where
- Thailand
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
IBD, Healthy
Effectiveness of PLENVU in the General Screening Population and Patients With IBD
Patients presenting for endoscopic surveillance of IBD or colorectal screening colonoscopy at one of the participating centers will be asked to participate in the present study after careful evaluation of inclusion and exclusion…
- Trial name
- NCT04457934
- Testing
- Plenvu
- Where
- 3 sites in Germany
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Constipation - Functional, Constipation
A Trial of Actazin Versus PEG 3350 for Maintenance Therapy in Children With Constipation
The goal of this pilot feasibility randomized controlled trial is to determine whether Actazin (kiwifruit extract) is a feasible and effective alternative to polyethylene glycol 3350 (PEG 3350) for maintenance therapy in children…
- Conditions
- Constipation - Functional, Constipation, Constipation Aggravated
- Trial name
- NCT06836024
- Testing
- Actazin chewable tablet, PEG 3350, Chewable Tablet
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Hamilton Health Sciences Corporation
Constipation, Cancer
Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients
This is a study to compare the efficacy and tolerability of two laxatives for treatment of opioid-induced constipation in adult outpatients with cancer treated at the British Columbia Cancer Pain and Symptom Management/Palliative…
- Trial name
- NCT01189409
- Testing
- PEG then Senna, Senna then PEG
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- British Columbia Cancer Agency
Constipation
Maintenance Treatment for Children With Constipation
Constipation is a common problem among children. The majority of children suffering from constipation have no underlying disease.
- Trial name
- NCT01566409
- Testing
- Polyethylene glycol 3350
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- Line Modin
Peripheral Nerve Injuries
Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)
The overall objective of this study is to determine the safety of PEG fusion when used with primary repair or reconstruction in patients with an acute upper extremity peripheral nerve injury.
- Trial name
- NCT04789044
- Testing
- NTX-001
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Major Extremity Trauma Research Consortium
Bowel Preparation
Comparing the Bowel Cleansing Efcacy of Picosulfate Sodium/ Citric Acid / Magnesium Oxide and Polyethylene Glycol: A Randomized Trial in Taiwan
This study aims to compare the intestinal cleansing efficacy, safety, tolerability, and acceptability of sodium picosulfate/magnesium citrate and polyethylene glycol in Taiwan.
- Trial name
- NCT06994585
- Testing
- Drinklear, Niflec
- Where
- Taiwan
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Colonoscopy
The Efficacy Side Effects and the Tolerance of Polyethylene Glycol 3350 as a Bowel Prep in Children
Bowel preparation solutions containing Polyethylene Glycol is a commonly used preparation of the colon for colonoscopy in children.
- Trial name
- NCT01164410
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Anemia, Kidney Disease, Chronic
An Observational Study of Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) in Patients With Chronic Kidney Disease in Pre-Dialysis or Dialysis
This prospective observational study will assess the efficacy and safety of Mircera (methoxy polyethylene glycol-epoetin beta) in clinical practice in patients with chronic kidney disease, in pre-dialysis or on dialysis…
- Trial name
- NCT01309295
- Where
- Albania
- Volunteers
- 250 people
- Sponsor
- Hoffmann-La Roche
Chronic Constipation
To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.
The purpose of this study is to determine whether Forlax® is more effective than placebo in relieving chronic constipation in children who may also suffer from soiling or faecal incontinence.
- Trial name
- NCT00255372
- Testing
- PEG 4000 (Forlax®)
- Where
- 2 sites in Thailand
- Volunteers
- 88 people
- Sponsor
- Ipsen
Water-Electrolyte Imbalance
Evaluation of One-day Polyethylene Glycol Powder Solution for Colonoscopy in Children
The purpose of this study is to examine the effects of current standard of care Polyethylene Gylcol powder (PEG-P)colonoscopy preparation on a patient's serum electrolytes, tolerance of the prep, and how well the bowel is…
- Trial name
- NCT01626040
- Testing
- polyethylene glycol powder
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Children's Hospital of Philadelphia
Hepatocellular Carcinoma
Chemoembolization Using LifePearl Polyethylene Glycol Drug Eluting Microspheres With Doxorubicin in HCC
The aim of this study is to collect data on efficacy and tolerability on a large series of patient of different Italian hospitals in order to support the validation of LifePearl with robust and consistent clinical evidence.
- Trial name
- LIFDOX (NCT03734068)
- Testing
- Chemoembolization Using LifePearl, Doxorubicin
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- International Group of Endovascular Oncology
Chronic Viral Hepatitis C
Comparative Pharmacokinetics and Pharmacodynamics of Peginterferon BIP48 and 40kDa in Healthy Volunteers
This research protocol "Comparative pharmacokinetics and pharmacodynamics of peginterferon Bacterial Intravenous Protein 48 kilodaltons (BIP48) and 40 kilodaltons (40kDa) in healthy volunteers." This is a Phase I clinical trial…
- Trial name
- NCT01889849
- Testing
- BIP 48, Pegasys
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Colonoscopy Preparation
PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy
Background: Polyethylene glycol (PEG) solution has been proven to be effective for large bowel cleansing prior to colonoscopy in children.
- Trial name
- NCT01531140
- Testing
- polyethylene glycol +Bisacodyl, Polyethylene glycol, Sennosides
- Where
- 2 sites in Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Healthy
Safety, Tolerance, and Pharmacokinetics of Single Oral Doses of BI 201335 NA and Bioavailability in Healthy Male Subjects
The objective of this study was to investigate the safety, tolerability, and pharmacokinetics of BI 201335 NA following administration of single rising doses from 4 mg to 1200 mg.
- Trial name
- NCT02182323
- Testing
- BI 201335 NA
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Colonic Disease, Intestinal Disease
Comparison for Efficacy and Safety of Bowel Preparation Between Oral Sulfate Table and 2L-polyethylene Glycol/Ascorbate in Elderly
This study compares the effectiveness and stability of intestinal tablet (OST), an oral sulfate table (OST), developed in the form of pills, with 2L-PEG/Asc for examinees aged 70 or older who are scheduled for colonoscopy.
- Trial name
- NCT05249335
- Testing
- OST, 2L-PEG/Asc
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Pharmbio Korea Co., Ltd.
Bowel Preparation
Compare the Effectiveness of Sports Drink and Water as a Solvent in Polyethylene Glycol for Colonoscopy
In this study, 200 patients were enrolled from 2023.1.1 to 2023.12.31, and were randomly divided into intervention and control groups.
- Trial name
- NCT05542810
- Testing
- Use sports drinks as polyethylene glycol solvents
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GanHuoye
Colonoscopy
Comparison of Different Low Volume Solutions Prior to Colonoscopy
Study evaluates the head -to-head efficacy and tolerability of low volume preparations prior to colonoscopy
- Trial name
- NCT03698474
- Testing
- Natrium picosulfate / Magnesium citrate, Polyethylene glycol / Ascorbic acid, Natrium/ Kalium/ Magnesium sulfate
- Where
- Czechia
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic