Clinical trials: Polymers
Coronary Heart Disease
Test of Long-Term Safety and Efficacy of Sirolimus-Permanent-Polymer Eluting Stent (Cypher)- and Sirolimus-Polymer-free Eluting Stents (PPS/PFS) Assessed by Optical Coherence Tomography
The objective of this pilot study is to compare the PFS-eluting stent (ISAR Rapa G1) with the PPS-eluting stent (Cypher®) regarding uncovered stent strut segments at 5 years.
- Trial name
- PPS/PFS-OCT (NCT01260558)
- Testing
- Sirolimus-Permanent-Polymer Eluting Stent, Sirolimus-Polymer-free Eluting Stent
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Recurrent Small Cell Lung Carcinoma
Pegylated Irinotecan NKTR 102 in Treating Patients With Relapsed Small Cell Lung Cancer
This phase II trial studies how well pegylated irinotecan NKTR 102 works in treating patients with small cell lung cancer that has returned after a period of improvement.
- Trial name
- NCT01876446
- Testing
- Laboratory Biomarker Analysis, Pegylated Irinotecan, Pharmacological Study
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Roswell Park Cancer Institute
Hypothermia
Comparison of a New Patient Warming System Using Polymer Conductive Warming With Forced Air Warming During Surgery
Two patient warming systems will be compared with 40 patients each in a convective warming group (BairHugger, Arizant) and in a conductive warming group (HotDog, Augustine Biomedical).
- Trial name
- HDV (NCT00772460)
- Testing
- Patient Warming with conductive / convective warming
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Hypothermia
Comparison of a New Patient Warming System Using a Polymer Conductive Warming Under-body and Upper-body Blanket With Forced Air Warming
Intraoperative active warming is usually performed by skin warming. There are several forced-air systems on the market; forced air warming is generally described as the most effective yet feasible method of patient warming.
- Trial name
- NCT01075724
- Testing
- Patient Warming with Forced Air, Resistive Warming
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Coronary Artery Disease, Diabetes Mellitus
Efficacy and Safety of Coronary Amphilimus-ELuting Stent in diAbeTic patiEnts
More recently a polymer-free drug eluting stent (Amphilimus eluting stent) has shown to have a superiority in terms of efficacy and safety if compared with stable polymer drug eluting stent when used in diabetic patients.
- Trial name
- ESCALATE (NCT03651180)
- Where
- Italy
- Volunteers
- 3,400 people
- Sponsor
- Ospedale S. Giovanni Bosco
Nasolabial Fold Wrinkles
Polymeric Microspheres vs Sculptra® in the Treatment of Moderate to Severe Nasolabial Folds
This is a single-dose, randomized, double-blind, active-controlled, split-face, multiple centers, non-inferiority study. Approximately 50 nasolabial fold subjects will be enrolled.
- Trial name
- NCT06013332
- Testing
- PBF PLLA microsphere (injectable poly-L-lactic acid), Sculptra®
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Hospital
Venous Leg Ulcer (VLU), Diabetic Foot Ulcer (DFU)
Effectiveness of Silicone Superabsorbent Polymer Dressings for Chronic Wound Management
The purpose of this single arm clinical study is to find out how well two Silicone superabsorbent polymer dressings, RespoSorb Silicone (also known as Zetuvit Plus Silicone) and RespoSorb Silicone Border (also known as Zetuvit…
- Trial name
- NCT07549737
- Testing
- RespoSorb Silicone (RSSil), RespoSorb Silicone Border (RSSB)
- Where
- 8 sites in Poland
- Volunteers
- 80 people
- Sponsor
- HARTMANN GROUP
Coronary Artery Disease, Myocardial Ischemia
Multivessel TALENT
Multivessel TALENT is a prospective, randomized, multi-center study comparing clinical outcomes between SUPRAFLEX Cruz and SYNERGY in approximately 1550 patients with de-novo three vessel disease undergoing percutaneous coronary…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- NCT04390672
- Testing
- SUPRAFLEX Cruz, SYNERGY
- Where
- Ireland
- Volunteers
- 1,550 people
- Sponsor
- National University of Ireland, Galway, Ireland
Glioblastoma Multiforme
Surgery With Implantable Biodegradable Carmustine (BCNU) Wafer Followed by Chemo for Patients With Recurrent Glioblastoma Multiforme
The purpose of this research study is to try and identify a more effective treatment plan to improve survival rates for patients with a recurrent Glioblastoma Multiforme (GBM) brain tumor that can be removed by brain surgery.
- Trial name
- NCT00984438
- Testing
- BCNU Wafer, Irinotecan, Bevacizumab
- Where
- United States
- Sponsor
- University of Cincinnati
Craniofacial Defects, Subtle, Skull Defect
Functionalized Bioink Delivering Biomolecules for the Treatment of Craniofacial Diseases
The study aims to address the challenges of craniofacial bone reconstruction in pediatric and adult patients affected by congenital craniofacial malformations (i.e.
- Conditions
- Craniofacial Defects, Subtle, Skull Defect, Craniosynostoses
- Trial name
- DART-CRAFT (NCT06533150)
- Testing
- multiomic profiling
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Coronary Syndrome, Angina Pectoris
Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents
Drug eluting stents (DES) are widely used for treatment of coronary artery lesions. The Xience Sierra stent has a refined design of the metal stent backbone and is used in patients with various clinical syndromes and in different…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- NCT04475380
- Testing
- Percutaneous coronary intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 1,757 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
NSCLC
A Prospective Phase II Clinical Study of Immunotherapy Combined With Chemotherapy for Stage III Unresectable Non-small Cell Lung Cancer
This study is a prospective, multicenter, open-label, single-arm Phase II clinical trial. The study recruits patients with stage III unresectable non-small cell lung cancer according to the 8th edition of the AJCC/UICC staging…
- Trial name
- NCT07082179
- Testing
- Iparomlimab and Tuvonralimab combined with paclitaxel polymer micelles and Platinum (cisplatin/carboplatin)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Hybrid Crowns on Single Implants in Esthetic Zone
Patient Satisfaction and Crestal Bone Loss of Polymer Infiltrated Ceramic Network Versus Lithium Disilicate Implant Hybrid Abutment Crowns in Esthetic Zone
P: Population: Patients requiring single unit implant restoration in esthetic zone I: Intervention: Polymer-infiltrated-ceramic-network abutment crown (VITA Enamic-VITA Zahnfabrik) C: Comparison: Lithium disilicate ceramic…
- Trial name
- NCT03333889
- Testing
- Vita Enamic hybrid crown, emax hybrid crown
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Tooth Decay
Resin Polymer (NuSmile BioFlx) Compared to Stainless Steel Crowns (3M ESPE) for Restoration of Primary Molar Teeth
The purpose of this research study is to test the effectiveness of two different crowns/caps on teeth for restoration of primary molar teeth. The two different materials of crowns are resin polymer and stainless steel crowns.
- Trial name
- NCT06354634
- Testing
- Resin polymer (NuSmile Bioflx) crown, Stainless steel crown
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University
Dermatitis, Atopic, Rosacea
A Study of a Polymeric Surfactant Technology Cleanser in Sensitive Skin Participants
The purpose of this study is to evaluate the efficacy and tolerance of a gentle facial cleanser in participants with sensitive skin (eczema/atopic dermatitis, rosacea, acne, cosmetic intolerance syndrome).
- Conditions
- Dermatitis, Atopic, Rosacea, Acne Vulgaris, Sensitive Skin
- Trial name
- NCT05094700
- Testing
- Non-marketed Cosmetic Facial Cleanser
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
ST Elevation Myocardial Infarction
STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT
Primary percutaneous coronary intervention (PCI) is the preferred revascularization strategy for patients with acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- STARS DAPT (NCT05785897)
- Testing
- Successful primary PCI, defined as primary PCI of the culprit lesion with ≥1 Abluminus NP polymer-free sirolimus-based nanocarrier eluting stent (Concept Medical Inc., India) implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- IGLESIAS Juan Fernando
Colon Cancer
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to Capecitabine Chemotherapy in Colon Cancer Treatment
Cancers of the colon and rectum are the third most common cancers in Canadian males and females. The initial therapy of colorectal cancer is surgery to remove the cancer and nearby lymph glands.
- Trial name
- NCT00126867
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- AHS Cancer Control Alberta
Brain and Central Nervous System Tumors
Internal Radiation Therapy Plus Carmustine Implants in Treating Patients With Recurrent or Refractory Malignant Glioma
RATIONALE: Internal radiation uses high-energy radiation to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003876
- Testing
- polifeprosan 20 with carmustine implant, surgical procedure, iodine I 125
- Where
- United States
- Sponsor
- Barrett Cancer Center
Late Acquired Stent Malaposition
Late Acquired Malaposition and Different Polymers
The polymers releasing the drug of first-generation drug-eluting stents (DES) may induce allergic reactions and inflammation, resulting in late-acquired stent malaposition (LASM) with uncoverage of struts, and risk of stent…
- Trial name
- NCT02018991
- Testing
- Everolimus-Eluting Stent (EES), Zotarolimus-Eluting-Stent (ZES), Biolimus-Eluting-Stent (BES)
- Where
- Austria
- Volunteers
- 69 people
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
First-in-man Trial Examining the Safety and Efficacy of BuMA Supreme and Resolute Integrity in Patients With de Novo Coronary Artery Stenosis
Prospective, multi-center, randomized 1:1, single blind trial using BuMA Supreme versus Resolute Integrity conducted in approximately 14 interventional cardiology centers in The Netherlands, Belgium, Spain and Portugal.
- Trial name
- NCT02236975
- Testing
- BuMA Supreme Biodegradable drug coating coronary stent system, Resolute Integrity durable polymer stent system
- Where
- 12 sites in Belgium, Netherlands and 2 more
- Volunteers
- 168 people
- Sponsor
- Sino Medical Sciences Technology Inc.