Clinical trials: Polymers
Coronary Artery Disease
Short-term Dual Antiplatelet Therapy After Deployment of Bioabsorbable Polymer Everolimus-eluting Stent
To compare the clinical outcomes of P2Y12 antagonist monotherapy with aspirin plus P2Y12 antagonist following 3-month of DAPT in patients undergoing PCI with bioabsorbable polymer Everolimus-eluting stents (Synergy®)
- Trial name
- NCT03447379
- Testing
- P2Y12 antagonist monotherapy, Aspirin plus P2Y12 antagonist
- Where
- South Korea
- Volunteers
- 1,452 people
- Sponsor
- Gangnam Severance Hospital
Periodontitis
Sterify Gel as an Adjunct to Non-Surgical Periodontal Therapy in Periodontitis
This retrospective observational study will evaluate the clinical response to Sterify Gel, a sterile mucoadhesive polymeric hydrogel, when used as an adjunct to non-surgical periodontal therapy in adult patients with stage II…
- Trial name
- Sterify (NCT07672665)
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Nasopharyngeal Carcinoma
TPC Versus GP Induction Chemotherapy for Nasopharyngeal Carcinoma
The NCCN guidelines recommend induction chemotherapy followed by concurrent chemoradiotherapy as the standard treatment for locoregionally advanced nasopharyngeal carcinoma (NPC).
- Trial name
- NCT06301165
- Testing
- TPC induction chemotherapy, GP induction chemotherapy
- Where
- 8 sites in China
- Volunteers
- 162 people
- Sponsor
- Sun Yat-sen University
Complete Tear, Knee, Anterior Cruciate Ligament
Clinical Evaluation of a Resorbable PLLA Implant for Regeneration of the Anterior Cruciate Ligament (ACL)
The purpose of this study is to evaluate the safety of a resorbable polymer implant (Soft Tissue Regeneration's L-C Ligament) for replacement and regeneration of the anterior cruciate ligament (ACL).
- Trial name
- NCT01634711
- Testing
- L-C Ligament
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Soft Tissue Regeneration, Inc.
Coronary Disease
Evaluation of HealinG of Polymer-Free Biomlimus A9-Coated Stent by Optical Coherence Tomography (EGO-BIOFREEDOM)
Since polymers have been identified as a possible cause of late complications of drug eluting stents, new stents are being designed to improve polymers' biocompatibility or to bond drugs on stents without polymers.
- Trial name
- NCT01760876
- Testing
- coronary intervention
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- Professor Stephen Lee
Mucosal Erosion, Gingival Recession
Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques
This study has been initiated to evaluate the question, "What is the best way to protect the palate after a gum graft is removed?" The overall objective is to determine if there is a difference in PROMs of donor site healing…
- Trial name
- NCT06892496
- Testing
- Visual Analog scale (VAS) questionnaire, Vacuum-formed retainer (VFR) technique, 3-D printed acrylic resin stent (3DS) technique
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Virginia Commonwealth University
Coronary Artery Disease
Clinical Investigation of the MiStent Drug Eluting Stent (DES) in Coronary Artery Disease
The DESSOLVE II clinical trial is to assess the safety and performance of the sirolimus-eluting MiStent for the treatment for improving coronary luminal diameter in patients with symptomatic ischemic heart disease due to discrete…
- Trial name
- DESSOLVE-II (NCT01294748)
- Testing
- MiStent DES, Endeavor DES
- Where
- 28 sites in Belgium, France and 4 more
- Volunteers
- 184 people
- Sponsor
- Micell Technologies
Coronary Artery Disease, Drug Eluting Stent
CREATE Trial, Prospective, Observational Study
Observation of the safety and effectiveness of Cre8 stent, Cre8 evo stent in patients with ischemic heart disease with long coronary lesions
- Trial name
- NCT05658250
- Testing
- CRE8 polymer-free Amphilimus-eluting stent, Cre8 evo stent
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Coronary Artery Disease
Comparison of BuMA eG Based BioDegradable Polymer Stent With EXCEL Biodegradable Polymer Sirolimus-eluting Stent in "Real-World" Practice
PANDA III is sought to investigate the safety and efficacy of a PLGA-polymer with electro-grafting base layer sirolimus-eluting stent (SES) versus a PLA-polymer SES at 12 months follow-up.
- Trial name
- PANDA-III (NCT02017275)
- Testing
- BuMA, EXCEL
- Where
- China
- Volunteers
- 2,348 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Lung Cancer Stage I, Lung; Node
Intra-operative Air Leak Management After Minimally Invasive Lung Segmental Resection
In patients undergoing minimally invasive thoracoscopic surgery (video-assisted thoracoscopic surgery, or VATS), a still unsolved issue is represented by intraoperative alveolar air leaks (IOAALs), which if prolonged beyond the…
- Conditions
- Lung Cancer Stage I, Lung; Node, Air Leak From Lung
- Trial name
- NCT06544200
- Testing
- Polymeric Hydrogel Matrix
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- University Hospital Padova
Severe Mitral Valve Regurgitation, Severe Mitral Valve Stenosis
The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease.
The study aims to evaluate the feasibility and safety of polymer artificial heart valve designed and developed by Shanghai HeartEpoch Medical technology Co. Ltd. for the treatment of the mitral valve diseases.
- Trial name
- HeartEpoch (NCT07243184)
- Testing
- mitral valve replacement
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai HeartEpoch Medical Technology Co., Ltd
Dental Polymer Based Filling Material
Bisphenol A in Saliva and Urine Related to Placement of Dental Composites
It has been reported that therapy with polymer-based dental filling materials was associated with higher concentrations of bisphenol A in saliva and urine directly after the treatment.
- Trial name
- NCT02575118
- Testing
- Restoration of dental caries with dental composite
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- NORCE Norwegian Research Centre AS
Coronary Artery Disease, Coronary Disease
Hybrid Sirolimus-eluting Versus Everolimus-eluting Stents for Total Coronary Occlusions
Percutaneous recanalization of total coronary occlusions (TCO) was historically hampered by high rates of restenosis and reocclusion.
- Conditions
- Coronary Artery Disease, Coronary Disease, Coronary Stenosis
- Trial name
- PRISON-IV (NCT01516723)
- Testing
- Hybrid sirolimus- and everolimus-eluting stents (ORSIRO, XIENCE PRIME)
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 330 people
- Sponsor
- R&D Cardiologie
Personal Satisfaction
Effect of Different Types of Crowns on Patient Satisfaction and Clinical Assesment
The aim of this study is to compare the patient satisfaction and clinical assessment (shade matching, surface texture and marginal discoloration) of Bio- High Performance Polymers (HPP) restoration versus E-max restoration…
- Trial name
- NCT02929173
- Testing
- Allceram, hybrid crown
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Foreign Body Granuloma, Surgery
"Outcomes of Surgical Removal of Foreign Body Granulomas"
Illicit subcutaneous injection of high-viscosity fluids for restoration and improvement of body contour is a growing trend all around the world. Many local and systemic complications have been described.
- Conditions
- Foreign Body Granuloma, Surgery, Complication
- Trial name
- NCT04661969
- Testing
- Surgery
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Hospital Angeles del Pedregal
Non-squamous NSCLC
Study of Polymeric Micellar Paclitaxel, Platinum Combined With Sindilizumab Injection for Advanced Non-squamous NSCLC
This is a prospective, single-arm, single-center, phaseⅡtrial to evaluate the efficacy and safety of Paclitaxel Polymeric Micelles for Injection, platinum (cisplatin/carboplatin) in combination with sindilizumab injection as…
- Trial name
- NCT05782426
- Testing
- paclitaxel polymeric micelles for injection
- Where
- 2 sites in China
- Volunteers
- 28 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Healthy
Bioavailability Study of 300 mg Trazodone Hydrochloride (New Polymer) vs. 300 mg Trazodone Hydrochloride (Contramid® Prolonged-release Tablets) Under Fasting Conditions
This study was designed to investigate the bioequivalence of the test and reference products when administered as single oral doses in two consecutive study periods, under fasting conditions.
- Trial name
- NCT05136521
- Testing
- Trazodone HCl - new polymer, Trazodone HCl - Contramid®
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Coronary Artery Disease
Optical Coherence Tomography Evaluation of a Biodegradable Polymer-based Drug-eluting Stent
PONTINA aims at assessing by optical coherence tomography the neointimal coverage of the biodegradable polymer-based Biolimus A9-eluting stent (Biomatrix stent) after full drug elution and polymer biodegradation (6 months), at…
- Trial name
- PONTINA (NCT01060306)
- Where
- Italy
- Sponsor
- Ospedale Santa Maria Goretti
Coronary Artery Disease, Diabetes Mellitus
Reservoir-Based Polymer-Free Amphilimus-Eluting Stent Versus Polymer-Based Everolimus-Eluting Stent in Diabetic Patients
This study is a prospective, randomized controlled, single blind, two-arm, multicenter clinical evaluation. Diabetic patients (n=112) with de novo coronary artery disease will be randomized to one of the 2 treatment arms: 1)…
- Trial name
- RESERVOIR (NCT01710748)
- Testing
- Polymer-Based Everolimus-Eluting Stent, Polymer-Free Amphilimus-Eluting Stent
- Where
- 4 sites in Spain
- Volunteers
- 112 people
- Sponsor
- Spanish Society of Cardiology
Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Carmustine Implants in Treating Patients With Brain Metastases
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different ways may kill more tumor cells.
- Trial name
- NCT00003878
- Testing
- polifeprosan 20 with carmustine implant, conventional surgery
- Where
- 11 sites in United States
- Sponsor
- New Approaches to Brain Tumor Therapy Consortium