Clinical trials: Polymers
Small Cell Lung Cancer, Non-small Cell Lung Cancer
A Study of Intravenous XMT-1001 in Patients With Advanced Solid Tumors
This amended expansion phase of the protocol is to further the experience at a dose level of 150 mg CPT eq/m2 in patients with Stage IV non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) and to test for…
- Trial name
- NCT00455052
- Testing
- XMT-1001
- Where
- 12 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mersana Therapeutics
Infection, Post-operative Care
The Use of a Novel Microbicidal Liquid Polymer for the Reduction of Pin Track Infection
The purpose of the study is to investigate additional clinical uses for the polymer, which is a FDA approved, 510k, medical device, but has not been approved for use on patients with pin track sites as a way to lower the…
- Trial name
- NCT03756506
- Testing
- Novel Microbicidal Liquid Polymer
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Prevent-Plus LLC
Endodontically Treated Molar, Marginal Fit
Assessment of Marginal and Internal Fit of High Performance Polymer PEEK Endocrown Using Two Preparation Designs
First, Participants in this study will be recruited according to inclusion criteria. Proper examination for the participants (clinically and radiographically).
- Conditions
- Endodontically Treated Molar, Marginal Fit, Internal Fit
- Trial name
- PEEK (NCT06500845)
- Testing
- Bevel marginal design endocrown for endodontically treated teeth, Butt marginal design endocrown for endodontically treated teeth
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Metastatic Colorectal Cancer
"Cancersensor": Circadian Rhythms
Observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched…
- Trial name
- NCT01693835
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pulmonary Emphysema, COPD
AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema
The purpose of this study is to assess the procedural and post-procedural safety and efficacy of AeriSeal therapy at up to 4 subsegments during a single treatment session in patients with GOLD Stage III/IV homogeneous or…
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- NCT01181466
- Testing
- AeriSeal System
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Aeris Therapeutics
Coronaropathy
Observatory to Assess the Yukon Choice PC & the Yukon Chrome PC Sirolimus Eluting Bioabsorbable Polymer Stents Systems
The TRANSLUMINA GmbH YuChooSeR Observatory is a prospective, multicentric post-marketing observatory designed to evaluate large scale safety and reliability of the Yukon Choice PC and the Yukon Chrome PC stents systems use in…
- Trial name
- YuChooSeR (NCT03918070)
- Testing
- Yukon Choice PC and Yukon Chrome PC
- Where
- 19 sites in France
- Volunteers
- 2,722 people
- Sponsor
- Translumina GmbH
Dry Eye Syndromes
Dual-Polymer Hydroxypropyl Guar-and Hyaluronic Acid Lubricants in Rheumatoid Arthritis
The goal of this clinical trial is to evaluate the efficacy of hydroxypropyl guar-and hyaluronic acid containing lubricant eye drops in rheumatoid arthritis patients .
- Trial name
- NCT06209879
- Testing
- SYSTANE™ Hydration Lubricant Eye Drops
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Coronary Artery Disease
Intra-patient Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT (Optical Coherence Tomography) Follow up
The objective of the study is to evaluate the process of early re-endothelialization of the Coroflex® ISAR Drug-eluting stent compared with the Ultimaster® Drug-eluting stent
- Trial name
- NCT02785237
- Testing
- Coroflex® ISAR Drug-eluting stent, Ultimaster® Drug-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Coronary Artery Disease
Elixir Medical Clinical Evaluation of the Novolimus-Eluting Coronary Stent System: A Randomized Study "EXCELLA II STUDY"
Randomized Study To evaluate the safety and effectiveness of the Elixir Medical DESyne Novolimus-Eluting Coronary Stent System with Durable Polymer through the assessment of clinical, angiographic and IVUS endpoints as compared…
- Trial name
- NCT00792753
- Testing
- Medtronic Endeavor Coronary Stent System, DESyne BD Novolimus Stent System, DESyne Novolimus Stent System
- Where
- 8 sites in Australia, Belgium and 6 more
- Volunteers
- 360 people
- Sponsor
- Elixir Medical Corporation
Cardiovascular Disease, Myocardial Infarction
A Prospective, Randomized Trial of BVS Veruss EES in Patients Undergoing Coronary Stenting for Myocardial Infarction
The aim of the current study is to test the clinical performance of the everolimus-eluting BVS compared with that of the durable polymer everolimus-eluting stent (EES) in patients undergoing PCI in the setting of acute MI.
- Conditions
- Cardiovascular Disease, Myocardial Infarction, Thrombus, Primary Angioplasty
- Trial name
- ISAR-Absorb MI (NCT01942070)
- Testing
- Bioresorbable vascular scaffold, Durable polymer everolimus-eluting metallic stent
- Where
- 2 sites in Germany
- Volunteers
- 262 people
- Sponsor
- Deutsches Herzzentrum Muenchen
STEMI - ST Elevation Myocardial Infarction
A Randomized Comparison of Long-Term Healing Between Biodegradable- Versus Durable-Polymer Everolimus Eluting Stents in STEMI
This study aims to compare the acute thrombogenecity and frequency of neoatherosclerotic lesions and other aspects of long term arterial healing such as the frequency of malapposed and uncovered stent struts at 3 years among…
- Trial name
- CONNECT (NCT03440801)
- Testing
- Synergy, Xience
- Where
- Japan
- Volunteers
- 240 people
- Sponsor
- Tokorozawa Heart Center
Advanced Solid Malignancies
A Trial to Determine the Maximum Tolerated Dose and Evaluate the Safety and Pharmacokinetics of Docetaxel-PNP, Polymeric Nanoparticle Formulation of Docetaxel, in Subjects With Advanced Solid Malignancies
This is a phase I trial to determine the maximum tolerated dose and recommended phase II dose of docetaxel-PNP (polymeric nanoparticle formulation of docetaxel) and to evaluate the safety and pharmacokinetics of docetaxel-PNP in…
- Trial name
- NCT01103791
- Testing
- Docetaxel-PNP
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Samyang Biopharmaceuticals Corporation
Hepatitis B, Chronic, Hepatitis D, Chronic
A Long Term Follow-up Study of Patients From the REP 301 Protocol
The REP 301 treatment protocol involved the treatment of patients with chronic hepatitis B / hepatitis D co-infection with two agents: REP 2139-Ca and pegylated interferon (peg-IFN).
- Trial name
- NCT02876419
- Where
- Moldova
- Volunteers
- 11 people
- Sponsor
- Replicor Inc.
Nail Diseases
Benefit of Topical Hemostatic Powder Containing Hydrophilic Polymer With Potassium Ferrate for Hemostasis Following Nail Surgery
The purpose of this study is to assess the efficacy and safety of topical hemostatic powder containing hydrophilic polymer with potassium ferrate for bleeding control after nail surgical procedures
- Trial name
- NCT04384679
- Testing
- Hydrophilic polymer and potassium ferrate powder
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Ischemia, Myocardial, Coronary Artery Disease
Comparison of an Ultra-low Strut Thickness Everolimus-eluting Biodegradable Polymer Stent Versus Durable Polymer Everolimus-eluting Stents in Patients Treated With Percutaneous Coronary Intervention
The objective of this randomized study is to compare the safety and efficacy of the ultra-low strut thickness everolimus-eluting biodegradable polymer Evermine50 stent to the everolimus-eluting family stents (durable polymer…
- Conditions
- Ischemia, Myocardial, Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
- Trial name
- SORT OUT XII (NCT06692140)
- Testing
- Ultra-low strut thickness everolimus-eluting biodegradable polymer Evermine50 stent(s), PCI with Everolimus-eluting stents (durable polymer everolimus-eluting Xience or Promus stent(s))
- Where
- 3 sites in Denmark
- Volunteers
- 3,150 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease
Assessment of Cutting-Balloon Angioplasty With Everolimus-Eluting Stent(EES) in the Treatment of Coronary Calcified Lesion(CCL) Guided by Intravascular Ultrasonography(IVUS)
The study seeks to address the clinical question of how effectively a novel cutting balloon (Wolverine™) can modify calcified lesions for stent implantation in comparison with a non-compliant (NC) balloon, particularly when used…
- Trial name
- NCT06177808
- Testing
- Wolverine cutting balloon, Non-compliant balloon
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Soonchunhyang University Hospital
Pulmonary Emphysema, COPD
AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation
The purpose of this study is to characterize the safety and efficacy of the AeriSeal System in patients with advanced upper lobe predominant emphysema and significant collateral ventilation as determined by the Chartis System.
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- CV+ (NCT01460108)
- Testing
- AeriSeal System
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Hepatocellular Carcinoma
Clinical Study Examining the Safety and Efficacy of Doxorubicin Drug Eluting Microspheres Transarterial Embolization in the Setting of Hepatocellular Carcinoma (HCC)
The study is designed to determine whether loading doxorubicin (a type of chemotherapy), when loaded onto a drug eluting microsphere will result in increased destruction of a tumor.
- Trial name
- NCT01116635
- Testing
- doxorubicin, superabsorbent polymer microspheres, embolotherapy
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
B-cell Lymphoma Refractory
Polymer-lipid Particle-delivered CAR1920 mRNA CAR-T Therapy for Relapsed/Refractory B-cell Lymphoma/Leukemia
The purpose of this study is to determine the efficacy and safety of the CAR-T cell immunotherapy utilizing polymer-lipid nanoparticles for delivering CD19/CD20 dual-targeting InViVoCAR1920 mRNA, for the first-line consolidation…
- Trial name
- NCT07321301
- Testing
- Polymer-Lipid Nanoparticle-Mediated Delivery of CD19/CD20 Dual-Targeting InViVoCAR1920 mRNA for CAR-T Cell Immunotherapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Daihong Liu
Metastatic Colorectal Cancer
"Cancersensor" Metastasis Resection
Observational, non randomized study aimed at measuring the effect of surgical resection of metastasis in the urinary concentrations of physiological modified nucleosides in 45 patients with metastatic colorectal cancer.
- Trial name
- NCT01693848
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France