Clinical trials: Polymorphism
Catecholaminergic Polymorphic Ventricular Tachycardia
A Phase 2 Study of CRD-4730 in CPVT
This is a Phase 2, multicenter, double-blind, sponsor blinded, placebo-controlled, repeat-dose clinical study of CRD-4730 to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CRD-4730 to…
- Trial name
- CPVT (NCT06658899)
- Testing
- CRD-4730
- Where
- 12 sites in United States, Canada and 4 more
- Volunteers
- 12 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.
Radiographic Contrast Agent Nephropathy
Relationship Between ALDH2 and CIN
The purpose of this clinical trial is to investigate the relationship between the gene polymorphism of aldehyde dehydrogenase 2 and contrast induced nephropathy and its mechanism.
- Trial name
- REACTION (NCT02643706)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Qilu Hospital of Shandong University
Cardiac Surgery
Catecholamine-O-Methyl-Transferase(COMT)-Polymorphism in Cardiac Surgery
Although clinical risk factors for postoperative development of vasodilatory shock and acute renal failure have been identified; there is a considerable proportion of patients undergoing cardiac surgery where this syndrome cannot…
- Trial name
- NCT00334009
- Where
- Australia
- Volunteers
- 250 people
- Sponsor
- Austin Health
Alcohol Drinking, Depression
Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
The two purposes of this study are 1. to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has 1.
- Conditions
- Alcohol Drinking, Depression, Smoking Cessation, Attention Deficit Disorder
- Trial name
- NCT00330434
- Testing
- Trial Withdrawn 1, Trial Withdrawn 2
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Hyperlipidemias
Effect of SLC01B1 (rs2306283) Polymorphism on the Efficacy and Safety Profile of Atorvastatin in Pakistani Population
The goal of this prospective cohort study was to identify the effect of SLC01B1 gene polymorphism in the Pakistani population. The main questions it aims to answer are: To identify polymorphism in SLOC1B1 (rs2306283) in the…
- Trial name
- NCT06674044
- Testing
- Atorvastatin
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Riphah International University
Stomach Ulcer
Influence of CYP2C19 Polymorphism on PK/PD of Omeprazole
A clinical trial to investigate the influence of CYP2C19 polymorphism on pharmacokinetic/pharmacodynamic characteristics of omeprazole in healthy Korean volunteers
- Trial name
- NCT02299687
- Testing
- Omeprazole
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
NON-SMALL-CELL LUNG CANCER
Identification of EGFR-TKIs Sensitivity or Resistance Markers in NSCLC May Help in Optimal Patient Selection
The aim of this study was to retrospectively evaluate associations between EGFR and AKT DNA-polymorphisms involved in transcriptional regulation and overall survival in NSCLC patients treated with EGFR-TKIs.
- Trial name
- NCT00831454
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Armando Santoro, MD
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Angiotensin Converting Enzyme rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases
Angiotensin Converting Enzyme rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases in Sohag Hospital University.
One of the most common medical approaches to the treatment of coronary artery disease (CAD) is the percutaneous coronary intervention (PCI) which became frequent due to high efficiency and safety of this procedure.
- Trial name
- NCT06055673
- Testing
- DNA extraction AND Real- time polymerase chain reaction analysis to POLYMORPHISM OF in in-stent restenosis (ISR) in CAD
- Where
- Egypt
- Volunteers
- 182 people
- Sponsor
- Sohag University
Psoriasis Vulgaris, Metabolic Syndrome
Analysis Of The Influence Of Metabolic Syndrome On Treatment Efficacy With Anti-Tnf In Moderate-Severe Psoriasis In Real Clinical Practice.
It has been reported in various epidemiological studies that patients with moderate-to-severe plaque psoriasis, with or without associated psoriatic arthritis, have an increased frequency of cardiovascular risk factors, such as…
- Trial name
- NCT01753245
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Juan Ruano
Polymorphism (Genetics), Endometriosis
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population
Endometriosis, defined as the presence of endometrial tissue outside the uterine cavity, affects 6-10% of the general population of women in childbearing age. The pathogenesis of the disease is unknown.
- Trial name
- NCT02388854
- Testing
- SNPs analysis with Sanger sequencing
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Dental Caries Secondary to Polymorphisms, Polymorphisms in Enamel Encoding Genes
Polymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS.
A Cross-Sectional Study aims to shed light on potential genetic determinants influencing dental caries susceptibility within this demographic and significantly understanding of genetic factors associated with dental caries…
- Trial name
- NCT06343766
- Testing
- DNA collation and genotyping
- Where
- Egypt
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Patients With Symptoms of Cardiac Arrhythmia at Risk for Atrial Fibrillation
THE GIRAFFE Study: Genomic Risk Markers for Atrial Fibrillation Following Extended Cardiac Rhythm Monitoring
Our primary hypothesis is that a risk score comprised of approximately 10 single nucleotide polymorphisms (SNPs) that are associated with atrial fibrillation at the Genome Wide Association Study (GWAS) level is associated with…
- Trial name
- GIRAFFE (NCT01970969)
- Where
- United States
- Volunteers
- 928 people
- Sponsor
- Scripps Translational Science Institute
Stuttering
Genetic Factors Related to Stuttering
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening…
- Trial name
- NCT00001602
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
COVID-19
VITACOV: Vitamin D Polymorphisms and Severity of COVID-19 Infection
Vitamin D deficiency has been linked to hypertension, autoimmune, infectious and cardiovascular diseases which are risk factors for COVID-19.
- Trial name
- VITACOV (NCT04370808)
- Testing
- Exposure
- Where
- 3 sites in Portugal
- Volunteers
- 517 people
- Sponsor
- University of Lisbon
Breast Cancer
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
A study to examine the potential associations between common single nucleotide polymorphisms and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
- Trial name
- NCT00329017
- Testing
- Fine needle aspiration
- Where
- United States
- Sponsor
- Carol Fabian, MD
Systemic Lupus Erythematosus
Cyclophosphamide in Lupus Nephritis
Cyclophosphamide is widely used in the treatment of cancer and autoimmune diseases such as lupus nephritis. However, there is considerable variability in the response to cyclophosphamide treatment.
- Trial name
- NCT00441220
- Where
- 3 sites in New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
Breast Neoplasms
The Effects of Circadian Gene on Sleep and Associated Symptoms in Breast Cancer Patients Under Chemotherapy
The purpose of this study is the evaluation of effect of circadian gene on sleep and other symptoms in breast cancer patients under chemotherapy.
- Trial name
- NCT01887925
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
Parkinson's Disease
Parkinson's Diseases Susceptibility Genes and Pesticides
Parkinson's disease (PD) occurrence is higher in rural than in urban populations of industrialized countries. Epidemiologic and human tissue studies suggest that pesticides may be responsible for causing dopaminergic cell death…
- Trial name
- NCT00044590
- Where
- United States
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Polymorphism, Lung Inflammation
Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function
Background: Respiratory diseases affect more than 1 billion people worldwide. They are a growing public health concern. The lungs are constantly exposed to environmental factors such as dust, fumes, microbes, and pollutants.
- Trial name
- NCT02743468
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)