Clinical trials: Polymorphism
Post-COVID-19 Syndrome
Physical Functions and Lifestyle Behaviours in Post-COVID-19 Syndrome Based on Circadian Rhythms
Post-COVID-19 syndrome is associated with persistent symptoms such as fatigue, reduced physical activity, and impaired respiratory function.
- Trial name
- NCT07545499
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Malaria
PALUREA: Severe Imported Malaria in Adults
Plasmodium falciparum malaria remains a major public health problem in endemic areas, with approximately 2 million deaths each year, especially in tropical African countries.
- Trial name
- PALUREA (NCT00372684)
- Testing
- with severe malaria hospitalized in ICU, with uncomplicated malaria
- Where
- France
- Volunteers
- 302 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Age-Related Macular Degeneration
Genetic Polymorphisms in Ranibizumab Treatment in Wet Age-Related Macular Degeneration (AMD)
Genetic factors of an individual patient may have an impact on Ranibizumab (Lucentis) treatment outcome in patients with Wet Age-Related Macular Degeneration (AMD).
- Trial name
- NCT01676506
- Testing
- Ranibizumab, Ranibizumab Injection
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Russian Academy of Medical Sciences
Hepatitis C, Chronic
Biliverdin Reductase A in Chronic Hepatitis C Virus Infection
In this project, the investigators aim to study the role of biliverdin reductase A (BLVRA) in HCV infected patients prior and during/after standard antiviral therapy in association with viral clearance, disease progression and…
- Trial name
- NCT01112033
- Where
- Czechia
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Thyroid Cancer
Salivary dysfuncTion After Radioiodine Treatment
Aim/Introduction: The treatment of differentiated thyroid cancer includes generally a total thyroidectomy, followed by a radioiodine (131I)-therapy.
- Trial name
- START (NCT04876287)
- Testing
- Radioiodine
- Where
- France
- Volunteers
- 138 people
- Sponsor
- French Nuclear Safety and Radiation Protection Authority (ASNR)
Healthy
Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects
Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects
- Trial name
- sibu (NCT01421706)
- Testing
- Sibutramine-clopidogrel, sibutramine-Clarithromycin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inje University
Cardiovascular Diseases
Identification of New Biomarkers for the Prediction of Cardiovascular Events
The main goal of this project is to constitute a collection of biological samples, obtained through the clinical activity of the Centre for Screening and Prevention of Atherosclerosis at Toulouse University Hospital, managing…
- Trial name
- CDPA-Biobank (NCT04809506)
- Testing
- additional blood samples
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Toulouse
Tryptophan Metabolism Alterations, Polymorphism
Effect of Genetic Alterations Affecting the Genes Encoding the Major Enzymes of the Kynurenine Pathway on Suicidal Behavior
Current research has shown that an imbalance in the Kynurenine pathway plays a role in the physiopathology of neurogenerative and mental disorders (with a decrease in neuroprotective metabolites and an increase in neurotoxic…
- Conditions
- Tryptophan Metabolism Alterations, Polymorphism, Suicidal Behavior
- Trial name
- SuiKYN (NCT04565834)
- Testing
- SNP (single nucleotide polymorphism) genotyping
- Where
- 2 sites in France, Spain
- Volunteers
- 849 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Breast Neoplasms, Arthralgia
CYP19 Genetic Polymorphism & Aromatase Inhibitor(AI)
The purpose of this study is to investigate the relationship between the side effects(especially arthralgia and arthritis) which appear in the patients who are prescribed aromatase inhibitor(AI) and the CYP19 genetic…
- Conditions
- Breast Neoplasms, Arthralgia, Arthritis, Genetic Polymorphism
- Trial name
- AI-CYP19 (NCT00973505)
- Testing
- Aromatase Inhibitor(Femara or Arimidex)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Anam Hospital
Disorders of Sex Development, Congenital Adrenal Hyperplasia
Gene Polymorphisms Influencing Steroid Synthesis and Action
The extend of steroid biosynthesis and action is mainly dependent on underlying genetic polymorphisms and gene mutations. These sequence variations in multiple genes involved in steroid biosynthesis and action cause different…
- Conditions
- Disorders of Sex Development, Congenital Adrenal Hyperplasia, Congenital Adrenal Hypoplasia, Adrenal Insufficiency
- Trial name
- NCT00485186
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Chronic Hepatitis C
Peripheral Blood Mononuclear Cell (PBMC) Gene Expression in HCV Genotype 1 Patients
Our previous collaborative studies has developed a molecular diagnosis tool, which is characterized with a prediction model consisting single nucleotide polymorphisms (SNPs), for assessing the efficacy of interferon combined…
- Trial name
- PBMC (NCT00680173)
- Testing
- pegylated interferon alpha 2a and plus ribavirin
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Non-small-cell Lung Cancer, Adenocarcinoma
TS Gene Polymorphism Predicts Effect in Patients With Advanced Lung Cancer
The investigators performed a multicenter, open trial of using TS gene polymorphism to predict advanced lung adenocarcinoma effect to pemetrexed combined with cisplatin regiment as first-line treatment.
- Trial name
- TPEIAL (NCT00940069)
- Testing
- pemetrexed
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hunan Province Tumor Hospital
Multiple Sclerosis
Pharmacogenetics of Liver Toxicity in Patients With Multiple Sclerosis Treated With Fingolimod
To investigate whether polymorphic differences can be identified between Multiple Sclerosis patients developing elevated liver enzymes (defined as ALT, AST, GGT or bilirubinemia levels five above the upper normal limit on at…
- Trial name
- NCT05516303
- Testing
- Genetic polymorphism, Measurement of fingolimod and fingolimod-phosphate concentrations
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Genetics in Hypertension
Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health.
- Trial name
- Beta2AR (NCT07832942)
- Testing
- low sodium diet, high sodium diet, renal plasma flow
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Brigham and Women's Hospital
Glucocorticoid Resistance, Gene
Association Between the Effect of Glucocorticoid Pulse Therapy on Neuromyelitis Optica (NMO) and Gene Polymorphism
Aims of this study are to observe the correlation between ABCB1、VDR、TBX21、NR3C1 and other gene polymorphisms and the effect of glucocorticoid shock therapy on neuromyelitis optica.
- Conditions
- Glucocorticoid Resistance, Gene, Neuromyelitis Optica
- Trial name
- NCT04601142
- Testing
- Methylprednisolone
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Beijing Tongren Hospital
Catecholaminergic Polymorphic Ventricular Tachycardia
Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia
The purpose of this study is to test whether the addition of oral flecainide to standard therapy will reduce ventricular ectopy on exercise test compared to placebo plus standard therapy in patients with Catecholaminergic…
- Trial name
- NCT01117454
- Testing
- Flecainide Acetate, Beta blocker
- Where
- 10 sites in United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Dietary Modification
Comparison of Two Calorie Restricted MediterrAsian Diet on Weight Loss in FTO rs9939609 Overweight Carriers
Background: Obesity treatment should be individualized since some calorie restricted diet doesn't work for some individuals. Objective: we assess the effect of two different calorie restriction with MediterrAsian diet on weight…
- Trial name
- NCT02940197
- Testing
- MediterrAsian diet
- Where
- Iran
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Daily Step Count, MASLD
The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD.
The study conducted a health survey among Thai adults in 2022 and found a significant increase in obesity and nonalcoholic fatty liver disease (NAFLD), leading to metabolic-associated steatotic liver disease (MASLD).
- Conditions
- Daily Step Count, MASLD, BMI, Metabolic Syndrome
- Trial name
- NCT06334666
- Testing
- Encourage using pedometer
- Where
- Thailand
- Volunteers
- 86 people
- Sponsor
- Mahidol University
Pulmonary Tuberculosis
Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)
The purpose of this study is to elucidate whether the individualized medicine based on NAT2 gene polymorphism could improve the safety, efficacy and economical benefits of multi-drug therapy for the pulmonary tuberculosis with…
- Trial name
- NCT00298870
- Testing
- Isoniazid, isoniazed
- Where
- 4 sites in Japan
- Volunteers
- 172 people
- Sponsor
- Osaka University
Genotype Guided(HNF4a), Healthy Subjects
STUDY The Effect of HNF-4A G60D Variant on the In VIVO CYP2D6 Activity By Tolterodine Pharmacokinetic Study
This study was to investigate the pharmacokinetics of tolterodine, substrate of CYP2D6 in healthy subject in relation to the presence of HNF-4A G60D variant.
- Trial name
- HNF4a (NCT01181505)
- Testing
- Tolterodine
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Inje University