Clinical trials: Polymorphism
Chronic Hepatitis C
SR-BI and Antiviral Treatment Response in HCV
The scavenger receptor type B class I (SR-BI) is a receptor for high-density lipoproteins (HDL) and one of entry factors for hepatitis C virus (HCV).
- Trial name
- NCT02714712
- Testing
- Peginterferon alfa-2a
- Volunteers
- 309 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder, EBV-Related Post-Transplant Lymphoproliferative Disorder
Epcoritamab for the Treatment of Relapsed or Refractory Post Transplant Lymphoproliferative Disorders
This phase Ib trial tests the safety and effectiveness of epcoritamab in treating patients with post-transplant lymphoproliferative disorder (PTLD) that has come back after a period of improvement (relapsed) or has not responded…
- Conditions
- Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder, EBV-Related Post-Transplant Lymphoproliferative Disorder, Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder, Recurrent Polymorphic Post-Transplant Lymphoproliferative Disorder
- Trial name
- NCT06672705
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Timothy Voorhees
Healthy Volunteers
CYP2B6 Polymorphisms in Methadone Disposition
This research study will determine if genetic variation in CYP2B6 affects how the body metabolizes methadone.
- Trial name
- NCT01648283
- Testing
- IV racemic methadone HCl, Oral racemic methadone HCl
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Hypertension
Target Organ Damage and Polymorphisms Vav-2 and Vav-3 in Hypertensive Subjects
Objectives: To analyze the influence on the presence of target organ damage renal, cardiac and vascular of peripheral and central blood pressure, retinal vessels caliber, oxidative stress and polymorphisms of genes VAV-2-3 in…
- Trial name
- LOD-HTA (NCT02022618)
- Where
- Spain
- Volunteers
- 454 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Healthy
Risk of CYP2C19 Phenoconversion in Healthy Volunteers With Rapid, Normal, and Intermediate Predicted Metabolizers' Status
CYP2C19 is responsible for the metabolism of approximately 10% of drugs currently on the market, including several proton pump inhibitors, clopidogrel, benzodiazepines and some tricyclic antidepressants, including amitriptyline.
- Trial name
- Switch19 (NCT05264142)
- Testing
- Voriconazole 200mg, FluvoxaMINE 50 Mg Oral Tablet, Omeprazole 10 MG Oral Tablet
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Children Who Receive a Stem Cell Transplantation With Busulfan IV
Polymorphisms and Busulfan Pharmacokinetic Study
Test the correlations between the pharmacogenetic and pharmacokinetic of Busulfan IV in children receiving hematopoietic stem cell transplantation.
- Trial name
- NCT01257854
- Where
- 4 sites in Canada, France and 1 more
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Muscle Strength, Genetics
Effectiveness of Muscular Work and Genetic Variants in Strength Gain of Ischiofemoral and Quadriceps
In the field of sports training and recovery, the work of muscular strength has become the star theme in terms of its influence on the performance of athletes.
- Trial name
- NCT03973060
- Testing
- Concentric-eccentric muscular work, Genetic polymorphism
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Sinus Arrhythmia
Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan
Background: Sinus node dysfunction is a major cause of bradycardia necessitating pacemaker implantation. Evidences of genetic study supported that some genes involved in the pacemaker current or renin-angiotensin system were…
- Trial name
- NCT00314223
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
NAFLD, Fatty Liver
A Nutrigenetic Intervention in MASLD
The study is designed as a 12-week randomized controlled dietary intervention in individuals who had been diagnosed with NAFLD in the last 6 months and whose body mass index is above 25 at the time of participation in the…
- Trial name
- NCT06220695
- Testing
- Dietary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Depression, Diabetes Mellitus
BDNF Level and val66met Polymorphism of Brain Derived Neurotropic Factor Gene in Patients With T2DM and Depression
This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes.
- Trial name
- NCT05526131
- Testing
- Questionare
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kasr El Aini Hospital
Type2 Diabetes
Association Between TMAO and Diabetes
Background: The association of trimethylamine-N-oxide (TMAO), a microbiota dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
- Trial name
- NCT03130894
- Testing
- Plasma TMAO concentration
- Volunteers
- 2,694 people, healthy volunteers welcome
- Sponsor
- Liegang Liu
System; Lupus Erythematosus
NCF Gene & TNFSF4 in SLE Patients
the investigators objective is to identify the association of SNP polymorphisms in the TNFS4, and NCF gene and SLE Egyptian patients.
- Trial name
- NCT05314881
- Testing
- TNFS4, NCF gene
- Volunteers
- 65 people
- Sponsor
- Assiut University
Chronic Bronchitis, Asthma
Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans
There is suggestive evidence for a role of dietary in the etiology of asthma and chronic bronchitis. However, there are few prospective data.
- Trial name
- NCT00342030
- Where
- Singapore
- Volunteers
- 63,257 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Multiple Sclerosis, Relapsing-Remitting
Polymorphisms of Interleukins, Glypican, and Human Leukocyte Antigen Genes and Treatment Response in Multiple Sclerosis.
HLA-DRB1 * Gene and some genes involved in inflammation and immunity (IL-7R, GPC5, CTSS) have been linked to risk of MS and the response to treatment with immunomodulators.
- Trial name
- WESTEMDRB1 (NCT02769767)
- Testing
- Polymorphism of Interleukins, Glypican, and Human Leukocyte Antigen Genes.
- Where
- Mexico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Instituto Jalisciense de Cancerologia
Stroke
Fangshan / Family-based Ischemic Stroke Study In China
The exact etiology of ischemic stroke remains unclear, because multiple genetic predispositions and environmental risk factors may be involved, and their interactions dictate the complexity.
- Trial name
- FISSIC (NCT00534742)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University
Sexual Dysfunction
Trazodone for SSRI-sexual Dsyfunction
The aim of this study is to investigate the efficacy of trazodone in the treatment of selective serotonin reuptake inhibitor(s) associated sexual dysfunction.
- Trial name
- T-SSRI-SD (NCT01097980)
- Testing
- Trazodone
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Beitou Armed Forces Hospital, Taipei, Taiwan
Lung Transplant, Chronic Allograft Rejection
Mechanisms of Lung Allograft Rejection
This study will explore the ways in which lung transplants are rejected. A series of experiments will evaluate the differences in airway gene expression.
- Trial name
- NCT00340418
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Bronchiolitis
Genetic Influences of Albuterol Response In Children With Bronchiolitis
Bronchiolitis is a significant cause of morbidity and hospitalization in children, accounting for approximately 125,000 hospitalizations per year in the U.S.
- Trial name
- NCT00570297
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Connecticut Children's Medical Center
Induced Pluripotent Stem Cells
Stem Cell Study of Genetics and Drug Addiction
Background: Researchers are interested in studying the roles that genes play in drug and alcohol addiction. Genes seem to account for about half of the differences between people who become addicted to drugs and people who do…
- Trial name
- NCT01534624
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Vitamin D Deficiency, Pregnancy
Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome
The VitDTracking study focuses on the relevance of maternal vitamin D levels and their association with prematurity, aiming to improve maternal and child health outcomes, particularly by reducing avoidable preterm births.
- Trial name
- VitDTracking (NCT06292195)
- Testing
- Exposure
- Where
- 3 sites in Portugal
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Évora