Clinical trials: Polymorphism-Genetic
Alzheimer Disease
REVEAL III: Risk Evaluation and Education for Alzheimer's Disease
The purpose of this study is to provide healthy adults with genetic testing and information about their chances of developing Alzheimer's disease.
- Trial name
- REVEAL (NCT00462917)
- Testing
- Pleiotropic info, in-person disclosure, AD-only info, in-person disclosure, Pleiotropic info, phone disclosure
- Where
- 4 sites in United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Congenital Heart Disease
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy
There are many kids born with congenital heart disease. Some of these defects may lead to the formation of a single ventricle (the heart having only one pumping chamber).
- Trial name
- NCT00165984
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Emory University
Puberty
The COPENHAGEN Puberty Study
By clinical examinations and withdrawing of blood samples from a large number of healthy Danish children, this study will reveal if age of pubertal onset is declining.
- Trial name
- NCT01411527
- Where
- Denmark
- Volunteers
- 1,957 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes Mellitus
Efficacy Study of Pioglitazone and Metformin and Association Between Pioglitazone Response and Peroxisome Proliferator-activated Receptor Gamma Gene Variants in Bangladeshi Type 2 Diabetes Mellitus Subjects
The present study was undertaken to assess the efficacy and safety of two different insulin sensitizers (namely Pioglitazone and Metformin) among subjects with type 2 diabetes mellitus (T2DM) in Bangladesh.
- Trial name
- T2DMCT (NCT01589445)
- Testing
- Pioglitazone hydrochloride, Metformin hydrochloride
- Where
- Bangladesh
- Volunteers
- 77 people
- Sponsor
- University of Dhaka
Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
Renin-angiotensin-aldosterone system (RAAS) polymorphisms influence 24h arterial pressure fluctuation. Resistant systemic arterial hypertension (RSAH) has an increased risk of end organ damage and unfavourable prognosis, whereas…
- Conditions
- Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy, Myocardial Infarction, Stroke
- Trial name
- GENHART (NCT01173029)
- Testing
- Anti-hypertensive drug treatment
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Universidade Gama Filho
Pain, Surgery
Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal Surgery
Purpose: This study aimed to investigate the impact of CYP3A4*1G genetic polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery.
- Trial name
- NCT01181492
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Huazhong University of Science and Technology
Pain, Surgery
The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
This study was conducted to explore whether the non-synonymous single-nucleotide polymorphisms in SCN9A gene can predict individual basal pain perception and postoperative pain intensity in the general population undergoing upper…
- Trial name
- NCT01507493
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xianwei Zhang
Vitamin D Receptor Defect
Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures
This study was designed to determine the impact of vitamin D serum levels and vitamin D receptor (VDR) polymorphisms on the occurrence of low energy fractures in children.
- Trial name
- NCT02805647
- Where
- Poland
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Coronary Heart Disease
The Clinical Diagnosis Meaning of MIF in Coronary Heart Disease
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that promote the inflammatory response.In animal studies, it has been found that MIF is released in the ischaemic heart, promoting glucose uptake and…
- Trial name
- NCT01750502
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Wenzhou Medical University
NAFLD
Genetic-specific Effects of Fructose on Liver Lipogenesis
The primary goal of this study is to identify a set of genotypes that increase the risk for nonalcoholic fatty liver disease (NAFLD) and predispose individuals to increased de novo lipogenesis (DNL) and liver fat accumulation…
- Trial name
- NCT03783195
- Testing
- Sugar drink
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections, Hyperlipidemia
Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin
Pravastatin (Pravachol) is approved by the Food and Drug Administration (FDA) and is used to treat high cholesterol. Darunavir (Prezista) and ritonavir (Norvir) are approved by the Food and Drug Administration (FDA) to treat HIV…
- Trial name
- NCT00630734
- Testing
- Pravastatin, Darunavir, Ritonavir
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2
Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes
Beta-blockers are medications used to treat cardiovascular disease (CVD) symptoms, including high blood pressure and chest pain.
- Trial name
- NCT00925119
- Testing
- Atenolol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Maryland, Baltimore
Temporomandibular Disorders
Study of Orofacial Pain and PropRANOlol
Purpose: Primary: To evaluate the efficacy of extended-release (ER) propranolol compared to placebo in the reduction of a pain index in patients with temporomandibular disorder (TMD).
- Trial name
- SOPPRANO (NCT02437383)
- Testing
- Propranolol ER
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes
GLP1R Polymorphisms and Response to GLP1
Glucagon-like Peptide-1 (GLP-1) is an important incretin hormone which acts as a powerful insulin secretagogue. Defects in GLP-1 synthesis and secretion are thought to be part of the pathogenesis of type 2 diabetes.
- Trial name
- NCT00588380
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sustained Virologic Response, IL28B Polymorphism
100% VS 80% Of Pegasys In Koreans With Chronic Hepatitis C (CHC)
1. Randomized controlled multicenter study 2. The response of reducing dose of peginterferon alfa-2a in Koreans with chronic hepatitis C genotype 1 3. IL28B polymorphism in Koreans with CHC
- Trial name
- NCT01378104
- Testing
- peginterferon alfa 2a (pegasys), peginterferon alfa-2a (pegasys)
- Where
- 14 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- The Catholic University of Korea
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Myocardiopathies, Ischemia, Myocardial
Extracellular Matrix Marker of Arrhythmia Risk (EMMA)
Assess whether serum levels of MMP 2 and or MMP 9 correlate with episodes of ventricular tachycardia or fibrillation in patients who have implantable cardioverter defibrillator devices.
- Conditions
- Myocardiopathies, Ischemia, Myocardial, Arrythmia, Death, Sudden, Cardiac
- Trial name
- EMMA (NCT00376532)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Thomas Jefferson University
Death, Sudden, Cardiac, Ventricular Fibrillation
DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.
To prospectively evaluate if the analysis of genetic polymorphisms can be used to identify patients at risk of ventricular tachycardia.
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Tachycardia, Atrial Fibrillation
- Trial name
- DISCOVERY (NCT00478933)
- Testing
- Defibrillator, Dual Chamber ; Implantable, Blood sampling
- Volunteers
- 1,223 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Pain, Postoperative
Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control.
- Trial name
- NCT00824772
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Inje University
Hepatitis B, Chronic
A Study Evaluating IL28B Polymorphism in Patients With HBeAg-Negative Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a) in Study ML18253
This cross-sectional multicenter study will evaluate the IL28B polymorphism in patients with HBeAg-negative chronic hepatitis B treated with Pegasys (peginterferon alfa-2a) in the predecessor ML18253 study.
- Trial name
- NCT01697501
- Testing
- Interleukin 28B testing
- Where
- 12 sites in Italy
- Volunteers
- 88 people
- Sponsor
- Hoffmann-La Roche