Clinical trials: Polymorphism-Genetic
Children With a Deficiency of Alpha-1 Antitrypsin
Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort
The deficiency of alpha-1 antitrypsin (DA1AT) is a genetic disorder of variable clinical expression, initially described in adults with pulmonary emphysema patients.
- Trial name
- Polygen (NCT01862211)
- Testing
- blood sampling
- Where
- 20 sites in France
- Volunteers
- 296 people
- Sponsor
- Hospices Civils de Lyon
Hyperlipidemias
Effect of SLC01B1 (rs2306283) Polymorphism on the Efficacy and Safety Profile of Atorvastatin in Pakistani Population
The goal of this prospective cohort study was to identify the effect of SLC01B1 gene polymorphism in the Pakistani population. The main questions it aims to answer are: To identify polymorphism in SLOC1B1 (rs2306283) in the…
- Trial name
- NCT06674044
- Testing
- Atorvastatin
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Riphah International University
Breast Neoplasms
The Effects of Circadian Gene on Sleep and Associated Symptoms in Breast Cancer Patients Under Chemotherapy
The purpose of this study is the evaluation of effect of circadian gene on sleep and other symptoms in breast cancer patients under chemotherapy.
- Trial name
- NCT01887925
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
GERD
CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing
Background/Aim: To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P (CYP) 2C19 polymorphism in a population…
- Trial name
- NCT00354757
- Testing
- rabeprazole
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
DiGeorge Syndrome, 22q11.2 Deletion Syndrome
Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
22q11.2 deletion syndrome is a genetic disorder that can cause heart defects, facial abnormalities, and developmental and learning disabilities. The severity of the disorder can vary widely among people.
- Trial name
- NCT00556530
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Albert Einstein College of Medicine
Breast Neoplasms, Survival Analysis
Study of Cytochrome P450 Polymorphisms (CYP2D6, CYP3A4/5 and CYP2C19) in Breast Cancer Patients
The genetic polymorphisms of the cytochrome P450 may influence on the metabolism of tamoxifen. The investigators want to evaluate the frequency or incidence of the genetic polymorphisms of cytochrome P450 subfamilies(CYP2D6…
- Conditions
- Breast Neoplasms, Survival Analysis, Antineoplastic Agents, Therapeutic Uses
- Trial name
- NCT01169792
- Testing
- tamoxifen
- Where
- 2 sites in South Korea
- Sponsor
- Yonsei University
Metastatic Colorectal Cancer
Escalated Dose of Irinotecan in mCRC
Metastatic diseases were found in 20-25% of patients with initial diagnosis of colorectal cancer and developed in up to 50% of patients.
- Trial name
- NCT02256800
- Testing
- UGT1A1 genotyping (6,6), UGTIA1 genotyping (6,7), UGTIA1 genotyping (7,7)
- Where
- Taiwan
- Volunteers
- 213 people
- Sponsor
- Jaw-Yuan Wang, MD, PhD
Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11, Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1
Study of Biomarkers in DNA Samples From Patients With Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia
This research study is looking at biomarkers in DNA samples from patients with acute lymphoblastic leukemia or acute myeloid leukemia.
- Conditions
- Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11, Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1, Adult Acute Promyelocytic Leukemia With PML-RARA, Childhood Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT01005277
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Children's Oncology Group
Non-Small Cell Lung Cancer
An Observational Research Of Crizotinib's Hepatic Toxicity In Non-small Cell Lung Cancer Patients
Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by Food and Drug Administration (FDA) for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC) and its administration has…
- Trial name
- NCT02708667
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Psoriatic Arthritis
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient
Psoriasis is a chronic, immune-mediated, multisystemic, inflammatory disease caused by the interaction of multiple susceptibility genes and environmental factors that affects 1-3% of the population worldwide .Psoriasis also is a…
- Trial name
- NCT06870500
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- South Valley University
Stroke
Mobile Terminal Based Management of Stroke Secondary Prevention Adminstration Effect Research
The investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform.
- Trial name
- NCT02618265
- Testing
- Mobile terminal, traditional management, website platform management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Mitral Valve Prolapse
Mitral Valve Prolapse (MVP) - France Study
This prospective nation-wide (France) study aims to search for susceptibility genes in MVP using a genome wide analysis and comparing results obtained in 1000 patients with MVP and 1000 non-MVP subjects.
- Trial name
- MVP-France (NCT00799565)
- Testing
- catch of blood
- Where
- 26 sites in France
- Volunteers
- 1,179 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Weight Management, Diet Conditions
A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs
The goal of this study is to determine the association between genotypes and diet. The weight and weight loss data are already available from the previously completed study called: A to Z Study - Benefits and Risks of Alternative…
- Conditions
- Weight Management, Diet Conditions, Dietary Recommendations, Overweight Management
- Trial name
- NCT00866151
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Interleukin Genetics, Inc.
Invasive Pulmonary Aspergillosis
CYP 2C19 Polymorphism and Voriconazole Trough Concentration in Chinese Adult Patients
To investigate the relationship between cytochrome P450 (CYP) 2C19 genetic polymorphism and the steady-state blood concentration of voriconazole in Chinese patients with invasive pulmonary aspergillosis (IPA), and to assess the…
- Trial name
- NCT02100761
- Testing
- Voriconazole
- Where
- China
- Volunteers
- 200 people
- Sponsor
- dingshifang
Healthy, Omega 3
Observing Metabolism of EPA With Consideration of Genetics And Sex
The goal of this clinical study is to learn how fast EPA is converted to other molecules, including DHA, with consideration of biological sex and genetics in healthy humans.
- Conditions
- Healthy, Omega 3, Metabolism, Lipids
- Trial name
- OMEGA (NCT06975241)
- Testing
- EPA 2.4g/day
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Vaccine Response Impaired, Allogeneic Stem Cell Transplantation
Role of Interferon-λ and Vaccine Response
The following observational study will investigate whether the vaccine response (antibodies, T and B cells) after allogeneic stem cell transplantation is influenced by genetic polymorphisms in the interferon lambda signal.
- Trial name
- NCT03467074
- Testing
- influenza A/B vaccine
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Abiraterone Acetate, Gene Polymorphism
Effects of Metabolic Enzymes and Transporter Gene Polymorphisms on the Pharmacokinetics and Metabolism of Oral Abiraterone Acetate in Healthy Chinese Adults
1. To explore the relationship between the changes of plasma concentration of abiraterone acetate after taken orally on fasting or postprandial and gene polymorphism. 2.
- Conditions
- Abiraterone Acetate, Gene Polymorphism, Pharmacokinetic, Metabolic Analysis
- Trial name
- NCT04735913
- Testing
- Abiraterone acetate tablets
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Polymorphism, Genetic, Bacterial Infections
The Association of Gene Polymorphisms With Invasive Bacterial Infections in Neonates and Young Infants
Invasive bacterial infections (IBIs) are globally significant, with high mortality rates, particularly within the critical 0-3 month age bracket.
- Conditions
- Polymorphism, Genetic, Bacterial Infections, Infant
- Trial name
- NCT06985160
- Testing
- Specific single nucleotide polymorphisms
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ege University
Healthy
Impact of Genetic Polymorphism on Drug-Drug Interactions Involving CYP2D6
CYP2D6 is characterized by a huge variability in the general population, mainly because of genetic polymorphism and drug-drug interactions (DDIs). CYP2D6 genotype is known to have an impact on the extent of DDIs.
- Trial name
- NCT03054220
- Testing
- Dextromethorphan 5 MG, Tramadol 10 mg, Duloxetine 60mg
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules