Clinical trials: Polynesian Bronchiectasis
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Primary Ciliary Dyskinesia, Kartagener Syndrome
Genetics of Primary Ciliary Dyskinesia
This study is designed to study DNA sequencings for mutations in a research genetic test panel of genes (which contains all 32 known and/or published genes associated with PCD).
- Trial name
- NCT02389049
- Where
- 8 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of North Carolina, Chapel Hill
Primary Ciliary Dyskinesia
Genetic Study of Patients With Primary Ciliary Dyskinesia
OBJECTIVES: I. Characterize the clinical presentation of patients with primary ciliary dyskinesia. II. Identify the genetic mutations associated with this disease.
- Trial name
- NCT00005650
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Center for Research Resources (NCRR)
Primary Ciliary Dyskinesia
Utility of PCD Diagnostics to Improve Clinical Care
This is a study evaluating the utility of current Primary Ciliary Dyskinesia (PCD) diagnostic tests, including nasal nitric oxide testing.
- Trial name
- NCT03704207
- Testing
- nNO testing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Cystic Fibrosis, COPD
High Resolution Micro OCT Imaging
The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.
- Conditions
- Cystic Fibrosis, COPD, PCD - Primary Ciliary Dyskinesia, Covid19
- Trial name
- NCT03256773
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Primary Ciliary Dyskinesia (PCD)
Comparison of Individuals With Primary Ciliary Dyskinesia and Healthy Controls
To date, the literature has not yet elucidated the status of malnutrition and sarcopenia in children and adolescents with PCD compared to healthy controls.
- Trial name
- NCT07740551
- Testing
- Physical Evaluations in Children with Primary Ciliary Dyskinesia, Physical Evaluations in Healthy Children
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Primary Ciliary Dyskinesia, Kartagener Syndrome
The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD)
The Ear-Nose-Throat (ENT) Prospective International Cohort of patients with Primary Ciliary Dyskinesia (EPIC-PCD) is a prospective observational clinical cohort study, set up as a multinational multi-centre study.
- Trial name
- EPIC-PCD (NCT04611516)
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University of Bern
Ciliary Motility Disorders, Primary Ciliary Dyskinesia
Genotype/Phenotype Correlation With Focus on Lung Function in Primary Ciliary Dyskinesia (PCD)
Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia associated with recurrent infections of the airways, laterality defects (Situs inversus totalis in about 50% of cases) and…
- Trial name
- LuFu_PCD (NCT04717115)
- Testing
- Genetic diagnosis
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Muenster
Bone Regeneration
Horizontal Ridge Augmentation in Mandible Usign ROG + ESWT
Guided bone regeneration (GBR) has been the most frequently used option to treat bone ridge deficiencies, allowing to restore such defects in order to place bone-integrated dental implants.
- Trial name
- NCT03785717
- Testing
- ROG, ROG & ESWT
- Where
- Colombia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Primary Ciliary Dyskinesia (PCD)
Malnutrition and Sarcopenia Among Primary Ciliary Dyskinesia
The prevalence and causes of malnutrition and sarcopenia in children and adolescents with Primary ciliary dyskinesia (PCD) have not been sufficiently elucidated.
- Trial name
- Malnutrition (NCT07740538)
- Testing
- Physical assessments of individuals
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Izmir Democracy University
Bronchiectasis Idiopathic, Cystic Fibrosis
WGS of Korean Idiopathic Bronchiectasis
Whole genome sequencing of Korean patients with idiopathic bronchiectasis and their family will perform to identify disease-causing variants.
- Conditions
- Bronchiectasis Idiopathic, Cystic Fibrosis, Primary Ciliary Dyskinesia
- Trial name
- WGS_UNK_BE (NCT03809091)
- Testing
- Whole genome sequencing
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Kartagener Syndrome
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease
The overall short-term goals of this project include the following: 1) identify the genes that are key to the function of respiratory cilia to protect the normal lung; and 2) the effects of genetic mutations that adversely affect…
- Trial name
- NCT00807482
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Primary Ciliary Dyskinesia
Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia
Primary ciliary dyskinesia is an autosomal recessive disorder characterized by abnormal ciliary movement and disrupted mucociliary clearance.
- Trial name
- NCT03370029
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Gazi University
Cystic Fibrosis, Primary Ciliary Dyskinesia
Multiple Breath Washout, a Clinimetric Dataset
Monitoring patients with chronic, inflammatory airways disease particularly in the early stages is hampered by the relative insensitivity of current outcome measures to detect subtle changes.
- Conditions
- Cystic Fibrosis, Primary Ciliary Dyskinesia, Bronchiectasis, Asthma
- Trial name
- NCT03320382
- Testing
- Multiple breath washout testing
- Where
- United Kingdom
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bronchiectasis, Cystic Fibrosis
Natural History of Bronchiectasis
Background: Bronchiectasis is a disease characterized by airways that are inflamed, abnormally dilated, and chronically infected. Individuals with bronchiectasis have a history of chronic and recurring respiratory infections.
- Conditions
- Bronchiectasis, Cystic Fibrosis, Autoimmune Disease, Common Variable Immunodeficiency
- Trial name
- NCT00943514
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Primary Ciliary Dyskinesia, Primary Immune Deficiency
Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults
The investigators will utilize a systematic approach for the diagnostic evaluation of patients to identify characteristics which may distinguish between Primary Immunodeficiency (PID) disorders versus Primary Ciliary Dyskinesia…
- Conditions
- Primary Ciliary Dyskinesia, Primary Immune Deficiency, Kartagener Syndrome
- Trial name
- NCT04702243
- Testing
- Genetic Testing for PCD or PID, Unaffected Family Member Genetic Testing
- Where
- 8 sites in United States, Canada
- Volunteers
- 436 people
- Sponsor
- University of North Carolina, Chapel Hill
Primary Ciliary Dyskinesia
Otolith Function in Patients With Primary Ciliary Dyskinesia
The purpose of this study is to determine whether patients with primary ciliary dyskinesia (PCD) have reduced or absent otolith function.The otolith system is a specific part of the inner ear vestibular (balance) system that…
- Trial name
- NCT01246258
- Testing
- Vestibular evoked myogenic potentials (VEMPs), Utricular centrifugation test
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College Healthcare NHS Trust
Primary Ciliary Dyskinesia
Registry Study on Primary Ciliary Dyskinesia in Chinese Children
This study is a multicenter, prospective cohort study of patients diagnosed with primary ciliary dyskinesia, the clinical information of recruited patients, including clinical manifestations, lung function, chest imaging, quality…
- Trial name
- NCT02704455
- Volunteers
- 100 people
- Sponsor
- Beijing Children's Hospital
Primary Ciliary Dyskinesia, Caries,Dental
Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia
The aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with Primary Ciliary Dyskinesia (PCD) with healthy children
- Conditions
- Primary Ciliary Dyskinesia, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06618209
- Testing
- physical and chemical methods, biochemical methods, Oral Findings
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Primary Ciliary Dyskinesia
A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
The goal of this observational study is to characterize clinical measures and biomarkers of airway disease in adults with primary ciliary dyskinesia (PCD) and in a group of healthy volunteers (HV) to establish normative values.
- Trial name
- NCT05685186
- Testing
- Spirometry, Multiple Breath Washout (MBW), Mucociliary Clearance (MCC)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- ReCode Therapeutics