Clinical trials: Polyneuropathy, open to volunteers
Sensory Neuropathy, Small Fiber Neuropathy
IVIG in Painful Sensory Neuropathy
The goal of this clinical trial is to assess effect of Intravenous immunoglobulins (antibodies) as compared to Placebo, on pain intensity in patients from 18-65 years with painful sensory neuropathy without a known cause.
- Trial name
- NCT06183008
- Testing
- Intravenous immunoglobulin
- Volunteers
- 20 people
- Sponsor
- Sorlandet Hospital HF
Hereditary Spastic Paraplegia
A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP
Through a prospective cohort study, we aim to dynamically evaluate the long-term benefits and risks associated with surgical interventions for hereditary spastic paraparesis (HSP) accompanied by foot deformities.
- Trial name
- HSP (NCT06936163)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 6th People's Hospital
HIV Associated Polyneuropathy
Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in…
- Trial name
- NCT07822932
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Chronic Inflammatory Demyelinating Polyneuropathy
A Study Investigating Intravenous Human Normal Immune Globulin (IGIV) 10% KIg10 (QIVIGY) in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
The current study is being conducted to assess the efficacy and safety of KIg10 (Intravenous Human Immune globulin 10%) at two different dosages as maintenance therapy for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)…
- Trial name
- NCT06752356
- Testing
- Immune globulin (human) 10% solution for intravenous administration
- Where
- 6 sites in United States
- Volunteers
- 161 people
- Sponsor
- Kedrion S.p.A.
Chemotherapy-induced Peripheral Neuropathy
Study of Wenyang Tongbi Formula in the Treatment of Chemotherapy-Induced Polyneuropathy
This clinical trial aims to evaluate the efficacy of Wenyang Tongbi Granules (a patented Traditional Chinese Medicine prescription) in treating chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07626528
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Polyneuropathy, Amyloidosis
Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause.
To investigate to what extent chronic axonal length-dependent polyneuropathy (CAP) and/or small-fiber neuropathy (SFN) is part of early non-cardiac manifestations of wild-type TTR cardiac amyloidosis (wtTTR-CA).
- Trial name
- NCT05950867
- Testing
- ECG + echocardiography, Answering questionnaires
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetic Neuropathy
Vitamin D, Nerve Growth Factor and Nerve Conduction Studies in Adult Male Type 2 Diabetic Neuropathy Patients
study the relationship of vitamin d with nerve growth factor level and nerve conduction studies in adult male type 2 diabetic neuropathy patients
- Trial name
- NCT07236723
- Testing
- nerve conduction studies, Nerve Growth Factor, 25(OH) vitamin D
- Where
- 2 sites in Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Aswan University
Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth
Natural History Study for Charcot Marie Tooth Disease
The goal of this Natural History Study for Charcot-Marie-Tooth is to acquire, record, and analyze patient-reported data and associated genetic reports, Electronic Health Records (EHRs) and clinical notes to identify the burden…
- Conditions
- Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth, Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A
- Trial name
- NCT05902351
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Hereditary Neuropathy Foundation
Guillain Barre Syndrome, Mechanical Ventilation
Early vs. Late Tracheostomy in Patients With Guillain -Barre Syndrome
Tracheostomy is one of the most common procedures in the intensive care unit in patients who need prolonged invasive mechanical ventilation.
- Trial name
- NCT06612242
- Testing
- early tracheostomy (less than 7 days from intubation), Late tracheostomy (more than 7 days from intubation)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome
Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity
Bardet-Biedl syndrome (BBS) and other rare disorders associated with impairment of the melanocortin-4 receptor (MC4R) pathway are characterized by severe early-onset obesity, hyperphagia, and substantial morbidity.
- Conditions
- Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome, Bardet-Biedl Syndrome (BBS), Alstrom Syndrome
- Trial name
- REAL-MC4 (NCT07674290)
- Testing
- Setmelanotide
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Tom Hühne
Metabolomics, Critical Care
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation.
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE I (NCT03810768)
- Where
- 3 sites in Austria, Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Inclusion Body Myositis, Myotonic Dystrophy 1
The Use of Assistive Gait Devices Can Reduce the Risk of Falls in Patients With Neuromuscular Diseases Following a Training Period.
The planned project is an intervention study to assess the risk of falling after adaptation of an assistive gait devices in patients with the following neuromuscular diseases: Inclusion body myositis, myotonic dystrophy, limb…
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy 1, Myotonic Dystrophy 2, Facio-Scapulo-Humeral Dystrophy
- Trial name
- Risk of fall (NCT07072676)
- Testing
- Assistive gait devices combined with physiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- LMU Klinikum
Charcot Marie Tooth Disease, DIFGAN
Genotype/Phenotype Correlation of MORC2 Mutations
The Microrchidia CW-type zinc finger 2 (MORC2) gene encodes a protein expressed in all tissues and enriched in the brain. It is involved in Charcot-Marie-Tooth disease, with mire than 30 families presenting MORC2 mutations.
- Conditions
- Charcot Marie Tooth Disease, DIFGAN, Developmental Delay (Disorder), Impaired Growth
- Trial name
- PhenoMORC2 (NCT07038239)
- Testing
- Skin biopsy, Blood sample
- Where
- 12 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Hereditary Spastic Paraplegia, Hereditary, Spastic Paraplegia, Autosomal Dominant
The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4
Study goals 1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease 2.
- Trial name
- NCT03206190
- Testing
- SPRS Score and clinical signs, Cognition Testing using CANTAB, Lumbar Puncture and blood draw
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
AMPD3, OMIM*102772, AMP Deaminase Deficiency, AK1, OMIM *103000, Adenylate Kinase Deficiency
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders
Background: Pyrimidine and purine metabolism disorders (DPPMs) affect how the body metabolizes chemicals called pyrimidines and purines.
- Conditions
- AMPD3, OMIM*102772, AMP Deaminase Deficiency, AK1, OMIM *103000, Adenylate Kinase Deficiency, AMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency, TPMT, OMIM *187680, Thoipurines, Poor Metabolism of
- Trial name
- NCT06092346
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
ICU-acquired Weakness, Critical Illness Polyneuropathy
Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness
This study aims to determine whether shear wave elastography (SWE), a non-invasive ultrasound technique that measures nerve stiffness, can help detect ICU-acquired weakness (ICU-AW) early in critically ill patients.
- Conditions
- ICU-acquired Weakness, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- NCT07594249
- Testing
- Nerve Ultrasound with Shear Wave Elastography
- Where
- China
- Volunteers
- 98 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Diabetic Polyneuropathy, Healthy Individuals (Controls)
PULP SENSIBILITY AND MASSETER INHIBITORY REFLEX IN DIABETIC POLYNEUROPATHY
Accurate evaluation of dental pulp health is essential to avoid unnecessary endodontic treatments. In routine dental practice, pulp sensibility is commonly assessed using electric pulp testing and thermal (cold) testing.
- Trial name
- NCT07369297
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia
Natural History Study of Patients with HPDL Mutations
This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations
- Conditions
- Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia, Spastic Paraplegia, White Matter Disease
- Trial name
- NCT05848271
- Testing
- Patient Registry, Dry blood spots sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
CMT, CMT (Charcot Marie Tooth Disease)
TREMOR IN CHARCOT-MARIE-TOOTH
Tremor is a symptom that has already been described in many case reports and case series concerning patients with Charcot-Marie-Tooth (CMT) disease.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), Charcot Marie Tooth Disease (CMT), Charcot Marie Tooth Disease
- Trial name
- CMT-TREM (NCT07570459)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen