Clinical trials: Polyp, Colonic
Colon Cancer
Augmentation of Screening Colonoscopy With Fecal Immunochemical Testing
The study will determine if adding fecal immunochemical testing (FIT) at yearly intervals to a colonoscopy screening program will improve colon cancer detection rates.
- Trial name
- ASC-FIT (NCT00892593)
- Testing
- Fecal Immunochemical Testing
- Where
- 3 sites in United States
- Volunteers
- 4,100 people
- Sponsor
- Forsyth Medical Center
Colonic Adenomatous Polyps
Effectiveness and Safety of the Colonoscopy With "Visualization" Balloon
Colonoscopy has become the "gold standard" in detection of colonic polyps and colon cancer. However, colonoscopy causes significant abdominal discomfort and abdominal pain during and after the procedure, requiring intravenous…
- Trial name
- NCT02117232
- Testing
- Visualization balloon, Traditional CO2 insufflation colonoscopy
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Mercy Medical Center
Colorectal Cancer, Colon Polyp
Efficacy of Free Versus Low Residue Diet as Preparation for Screening Colonoscopy
One tricky aspect of the recommendations for colonoscopy prep is diet. This has a significant impact on the experience of the patient or participant in the screening program and, on the other hand, low adherence has been found in…
- Conditions
- Colorectal Cancer, Colon Polyp, Colon Adenoma
- Trial name
- CriLi (NCT04664543)
- Testing
- Free diet, Three days low residue diet
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Parc Taulí Hospital Universitari
Gastric Cancer, Colorectal Cancer and Pre-cancer Polyps
Identifying Saliva Markers of Patients With Stomach, Colorectal (Including Pre-cancer Polyp) and Pancreatic Cancers
Colorectal cancers account for 783,000 new cases and cause 437,000 deaths per year across the world. Diagnosis in the early stages improves survival rates.
- Conditions
- Gastric Cancer, Colorectal Cancer and Pre-cancer Polyps, Pancreatic Cancer
- Trial name
- NCT01675258
- Testing
- Salivary samples
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Familial Adenomatous Polyposis
Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP)
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder linked to a mutation in the APC gene, associated with the development of multiple colonic and duodenal adenomas, which in 100% of cases progress to…
- Trial name
- NCT06614738
- Testing
- Sampling of feces and duodenal fluids
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Polyps, Colorectal Neoplasm
Colorectal Polyps Screening With Low-dose CT Colonoscopy
This preliminary clinical trial aims to evaluate the performance of the low-dose CT colonoscopy (CTC) with computer aided detection (CAD) on polyps detection compared with optical colonoscopy (OC), and explore the possible…
- Trial name
- NCT03064828
- Testing
- CT colonoscopy(normal dose), CT colonoscopy (low dose)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Colonic Polyp, Colonoscopy
Impact of Artificial Intelligence Genius® System-assisted Colonoscopy vs. Standard Colonoscopy (COLO-GENIUS)
This controlled-randomized trial compares the artificial intelligence Genius® system assisted (Genius+) to standard (Genius-) colonoscopy.
- Conditions
- Colonic Polyp, Colonoscopy, Artificial Intelligence, Colonic Adenoma
- Trial name
- COLO-GENIUS (NCT04440865)
- Testing
- Genius® System-assisted Colonoscopy, Standard Colonoscopy
- Where
- France
- Volunteers
- 2,100 people
- Sponsor
- Clinique Paris-Bercy
Gardner Syndrome, Colorectal Carcinoma
A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome
The purpose of this study is to assess the long-term outcome in a cohort of Gardner-Syndrome patients receiving prophylaxis and treatment for intestinal and non-intestinal tumors.
- Conditions
- Gardner Syndrome, Colorectal Carcinoma, Desmoid Tumor
- Trial name
- NCT01286662
- Volunteers
- 105 people
- Sponsor
- Triemli Hospital
Colorectal Cancer, Colon Polyps
Prevalence and Topography of Adenomas in 40-49 Year Old Patients With a Family History of Colon Cancer
Conflicting guideline recommendations for screening colonoscopy result due to scant data upon which to develop appropriate recommendations.
- Conditions
- Colorectal Cancer, Colon Polyps, Adenomatous Polyp of Colon
- Trial name
- NCT02289053
- Where
- 6 sites in United States
- Volunteers
- 1,623 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Polyps, Colon Cancer
Endoscopic Full Thickness Resection Versus Standard Therapy of the Colorectal Neoplasia
Most of the cancers develop from the adenomatous polyps. The therapeutic methods have been established already - endoscopic polypectomy (EPE) for stalked polyps and endoscopic mucosal resection (EMR) or endoscopic submucosal…
- Trial name
- NCT03868605
- Testing
- EMR and ESD, Over- the- scope full- thickness resection device
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Military University Hospital, Prague
Familial Adenomatous Polyposis
Niclosamide for Familial Adenomatous Polyposis
Familial adenomatous polyposis (FAP) leads to adenomas and eventual adenocarcinomas in colon and less frequently, duodenum. Chemopreventive strategies have been studied in FAP patients to delay the development of adenomas and…
- Trial name
- NCT04296851
- Testing
- Niclosamide
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Colonic Polyp
Impact of Augmented Reality in Polypectomy Skills Acquisition in Simulation-based Endoscopy Training
Simulation-based training (SBT) is a safe and effective strategy for improving skills development in gastrointestinal endoscopy.
- Trial name
- NCT03826069
- Testing
- Augmented reality-based curriculum, Conventional Simulation Curriculum
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Combizym, Bifidobacteri
The Clinical Study on Combizym and Bifidobacteri to Prevent the Recurrence of Colon Polyps
The study hypothesis is whether digestion enzyme(Combizym) and intestinal flora drugs(Bifidobacteria) can decease recurrence rate of colon polyps
- Conditions
- Combizym, Bifidobacteri, Colon Polyps
- Trial name
- NCT02097394
- Testing
- Combizym, Bifidobacteri, Combizym + Bifidobacteri
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Colorectal Cancer, Colorectal Polyps
Urine Metabolomics and Colorectal Cancer Screening
This is a prospective, multi-centered study to assess whether urine metabolomics can play a role in the screening of colorectal cancer (CRC).
- Trial name
- NCT01486745
- Where
- Canada
- Volunteers
- 2,175 people
- Sponsor
- University of Alberta
Familial Adenomatous Polyposis
Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients
The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.
- Trial name
- NCT00248053
- Testing
- curcumin
- Sponsor
- Johns Hopkins University
Rectal Cancer, Colon Cancer
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can assess viability of colon tissue during laparoscopic…
- Conditions
- Rectal Cancer, Colon Cancer, Crohn's Disease, Polyp
- Trial name
- PILLAR II (NCT01560377)
- Testing
- PINPOINT Endoscopic Fluorescence Imaging System
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Serrated Polyp, Colorectal Neoplasms
Increasing Serrated Polyp Detection With a Brief Awareness Training
In this non-randomized controlled trial, a semi-random group of Dutch endoscopist receive an oral training about the significance of serrated polyps.
- Trial name
- NCT03902899
- Testing
- Educational intervention (oral presentation)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Cancer Screening
Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure
This study is designed to determine the optimal bowel preparation regimen for PillCam® COLON 2 Capsule Endoscopy System (CCE) procedures in average risk patients.
- Trial name
- NCT02481219
- Testing
- PillCam® COLON 2 procedure-CONTROL, Senna tablets, PEG
- Where
- 6 sites in United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Adenoma Colon Polyp, Adenoma Colon
Clinical Evaluation of a New Platform for Bi-manual Endoscopic Resection in the Rectum and Sigma (EndoTEM)
The goal of this clinical trial is to determine whether the use of the EndoTEM system during the endoscopic removal of polyps in the distal colon is feasible and safe.
- Trial name
- EndoTEM (NCT07146165)
- Testing
- EndoTEM resection platform and technique
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Shared Decision Making, Colonic Polyp
The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp
Management of unexpected malignant colorectal polyps removed endoscopically can be challenging due to the risk of residual tumor and lymphatic spread.
- Conditions
- Shared Decision Making, Colonic Polyp, Decision Aids, Rectal Polyp
- Trial name
- NCT05776381
- Testing
- Shared Decision Making using a Patient Decision Aid.
- Volunteers
- 110 people
- Sponsor
- Vejle Hospital