Clinical trials: Polyp
Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS)
Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray
Background: Allergic fungal rhinosinusitis (AFRS) is a severe type of sinus infection. People with AFRS develop heavy mucus and growths called polyps that apply pressure to the sinuses and block their breathing.
- Conditions
- Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS), Asthma, Nasal Polyps
- Trial name
- NCT06461949
- Testing
- Dupilumab
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Colorectal Polyp, Colorectal Neoplasms
Narrow Band Imaging in Diagnosis of Colorectal Polyps
Optical diagnosis of colorectal polyps is a promising tool to avoid risks of unnecessary polypectomies and to save costs of tissue pathology.
- Trial name
- NCT04831814
- Testing
- Near Focus NBI, Standard Focus NBI
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Prince of Songkla University
Sinusitis, Nasal Polyps
Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps
Verapamil is an L-type calcium channel blocker(CCB) which has been shown to reduce inflammation in a variety of tissues. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by eosinophilic inflammation as well as…
- Trial name
- NCT03102190
- Testing
- Verapamil Hydrochloride Intranasal
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Benjamin Bleier
Colorectal Adenoma
A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas (0966-122)
This study was to compare the effect of 156 weeks of treatment with MK-0966 (Rofecoxib) versus placebo on the recurrence of colorectal adenomas (growths that occur on the inside (the lining) of the large intestine, also known as…
- Trial name
- NCT00282386
- Testing
- MK0966; Rofecoxib / Duration of Treatment: 156 weeks
- Volunteers
- 2,586 people
- Sponsor
- Merck Sharp & Dohme LLC
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Colorectal Cancer, Adenomatous Colorectal Polyps
Selenium for Prevention of Adenomatous Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Selenium may be effective in preventing the recurrence of adenomatous colorectal polyps.
- Conditions
- Colorectal Cancer, Adenomatous Colorectal Polyps, Precancerous Condition
- Trial name
- NCT00078897
- Testing
- Selenium
- Where
- 7 sites in United States
- Volunteers
- 1,621 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Endoscopic Assessment, Colonic Polyps
Resect and Discard Strategy in Clinical Practice
Nowadays, post-polypectomy surveillance intervals are determined by combining endoscopic and pathologic data. Real-time imaging technologies, have shown promising results in discriminating adenomatous from non-adenomatous polyps.
- Conditions
- Endoscopic Assessment, Colonic Polyps, Endoscopic Surveillance, NBI
- Trial name
- NCT01462123
- Testing
- endoscopic assessment of colonic polyps
- Where
- Italy
- Volunteers
- 286 people
- Sponsor
- Valduce Hospital
Intrauterine Polyp, Intrauterine Synechiae
Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care
Cervical dilation-induced somatic responses remain a critical challenge in ambulatory hysteroscopic surgery. Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exhibits unique analgesic and sedative properties that…
- Trial name
- NCT07034963
- Testing
- Determine the ED50 and ED95 of esketamine, Intravenous the dose of esketamine ED95, Intravenous remifentanil 1μg∙kg-1
- Where
- China
- Volunteers
- 95 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Chronic Rhinosinusitis Without Nasal Polyps, Asthma
Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis
The purpose of this study is to investigate the relationship between long-term use of systemic steroids in patients with upper and lower respiratory tract diseases and their own production of cortisol (cross-sectional), as well…
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps, Asthma, Chronic Rhinosinusitis With Nasal Polyps, Steroid-Induced Osteopenia (Diagnosis)
- Trial name
- AGAS 2023 (NCT05843019)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Christiane Haase
Sessile Serrated Adenoma/Polyps
Usefulness of NBI for Complete Endoscopic Resection of SSA/P
This study is a prospective randomized study to evaluate the role of NBI for improving complete resection rate of sessile serrated adenoma/polyp (SSA/P).
- Trial name
- NCT03761667
- Testing
- Endoscopy using Narrow band imaging
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Colorectal Polyp
ORISE Study: Evaluation of Novel Injecting Solution (ORISE) During Endoscopic Resection of Colorectal Polyps.
Is ORISE Gel an effective and feasible submucosal injecting solution during endoscopic resection of large colorectal polyps.
- Trial name
- ORISE (NCT04886609)
- Testing
- ORISE gel
- Where
- 5 sites in Italy, United Kingdom
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Colorectal Cancer, Polyps
e-Nose and Colorectal Cancer
Colorectal cancer (CRC) is the third most common new cancer diagnosis and a major cause of morbidity and mortality throughout the world.
- Trial name
- NCT03488537
- Testing
- AeonoseTM
- Where
- Netherlands
- Volunteers
- 511 people
- Sponsor
- Radboud University Medical Center
Polyps, Colorectal Neoplasm
Colorectal Polyps Screening With Low-dose CT Colonoscopy
This preliminary clinical trial aims to evaluate the performance of the low-dose CT colonoscopy (CTC) with computer aided detection (CAD) on polyps detection compared with optical colonoscopy (OC), and explore the possible…
- Trial name
- NCT03064828
- Testing
- CT colonoscopy(normal dose), CT colonoscopy (low dose)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Familial Adenomatous Polyposis
Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance
Patients with Familial Adenomatous Polyposis (FAP) who are undergoing endoscopic surveillance will be given Encapsulated Rapamycin (eRapa) at one of three escalating doses/schedules for 12 months with the aim of reducing polyp…
- Trial name
- NCT04230499
- Testing
- Encapsulated Rapamycin (eRapa)
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rapamycin Holdings Inc.
Polyp of Colon
Impact of Artificial Intelligence (AI) on Adenoma Detection During Colonoscopy in FIT+ Patients.
The Italian screening program invites the resident population aged 50-74 for Fecal Immunochemical Test (FIT) every 2 years. Subjects who test positive are referred for colonoscopy.
- Trial name
- AIFIT (NCT04691401)
- Testing
- Artificial Intelligence System (CAD EYE, Fujifilm Co.)
- Where
- Italy
- Volunteers
- 750 people
- Sponsor
- Valduce Hospital
Colonic Adenoma, Colonoscopy
Blue Laser Imaging and White Light Imaging Colonic Polyps
The adenoma detection rate by colonoscopy for asymptomatic individuals aged 50 years and older is estimated to be at least 25%. It is known that during colonoscopy, lesions may be missed.
- Trial name
- NCT03421600
- Testing
- blue laser imaging, White light imaging
- Where
- Singapore
- Volunteers
- 184 people
- Sponsor
- Changi General Hospital
Screening of Colonic Polyps
Techniques to Enhance Patient Comfort in Sedation-risk Free Colonoscopy
Hypotheses 1. Loading the sigmoid colon with warm water and warm water irrigation for dealing with spasm (Study Treatment) will significantly reduce the proportion of patients complaining of abdominal discomfort compared with no…
- Trial name
- NCT01076907
- Testing
- Warm water, Control
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Adenoma, Colo-rectal Cancer
Clinical Value of G-EYE Colonoscopy in Daily Practice for Adenoma Detection and Time for Polyp Removal
Colonoscopy parameters will be compared before the introduction of the G-EYE endoscope and after the introduction of the G-EYE endoscope
- Trial name
- NCT04767971
- Testing
- Standard Colonoscopy, G-EYE Colonoscopy
- Where
- Germany
- Volunteers
- 2,795 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Colorectal Cancer
Telemark Polyp Study, a Trial on Colonoscopy Screening
Colonoscopy screening to reduce mortality and incidence of colorectal cancer (CRC) has been implemented in many western countries. The estimated effect is based on case-control and observational studies.
- Trial name
- TPS (NCT01014039)
- Testing
- Flexible Sigmoidoscopy Screening arm
- Where
- Norway
- Volunteers
- 1,433 people, healthy volunteers welcome
- Sponsor
- Norwegian Department of Health and Social Affairs
Chronic Rhinosinusitis
Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes
Dexamethasone added to sinufoam, which is placed in the ethmoid cavity at the completion of endoscopic sinus surgery, will improve sinonasal mucosal healing.
- Trial name
- NCT01024075
- Testing
- Dexamethasone, Saline
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary