Clinical trials: Polyp Colorectal
Colorectal Neoplasm, Endoscopic Mucosal Resection
ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Colonic Laterally spreading lesions (LSL) => 20mm are at high risk to progress to cancer. Overt stigmata of submucosal invasive cancer (SMIC) has been well characterized and includes ulceration and surface pit pattern changes as…
- Trial name
- COVERT (NCT04008407)
- Testing
- Endoscopic Submucosal Dissection, Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 391 people
- Sponsor
- Western Sydney Local Health District
Diminutive Colorectal Polyp, Cold Snare Polypectomy
The Effectiveness of an Exclusive Cold Snare Polypectomy Snare for the Removal of Diminutive Colorectal Polyps
The use of an exclusive cold polypectomy snare enables a clean cut of diminutive colorectal polyps, resulting in an increase in the complete resection rate and a decrease in the adverse events.
- Conditions
- Diminutive Colorectal Polyp, Cold Snare Polypectomy, Polypectomy Snare, Complete Resection Rate
- Trial name
- NCT02036047
- Testing
- exclusive cold polypectomy snare (Exacto cold snare, product number 00711115), Regular polypectomy snare (Snare Master, SD-210U-10)
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Showa Inan General Hospital
Bowel Cancer, Polyp Rectal
Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal
1.1 Polyps or tumours in the lower part of the bowel (rectum) can be removed using instruments inserted through the bottom which avoids major surgery and the possibility of a stoma bag (colostomy).
- Conditions
- Bowel Cancer, Polyp Rectal, Rectal Cancer, Rectal Adenocarcinoma
- Trial name
- R-ALERT (NCT07341126)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Adenomatous Polyps
A Comparison of the Resection Rate for Cold and Hot Snare Polypectomy for 5-15 mm Colorectal Polyps
In 2015, there were approximately 1.7 million new cases of colorectal cancer（CRC）, and the deaths was close to 832,000. CRC has become the third most common malignant tumor in the world and the second leading cause of cancer…
- Trial name
- NCT04061005
- Testing
- Cold snare polypectomy, Hot snare polypectomy, Endoscopic margin observation method
- Where
- China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Yuqi He
Colorectal Cancer, Polyps
Magnetic Resonance (MR) Colonography With Fecal Tagging
The purpose of this study is to determine if MR colonography with fecal tagging is better using air or water for distension of the colon. Patients referred to colonoscopy are offered MR colonography before colonoscopy.
- Trial name
- NCT00114842
- Testing
- MR colonography
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Herlev Hospital
Familial Adenomatous Polyposis (FAP)
Expanded Access to 0.5 mg eRapa for Familial Adenomatous Polyposis
This expanded access program provides 0.5 mg eRapa (encapsulated rapamycin) to patients with familial adenomatous polyposis (FAP) who have no satisfactory alternative treatment options and are not eligible to participate in a…
- Trial name
- eRapa-FAP (NCT07689942)
- Testing
- eRapa (encapsulated rapamycin)
- Sponsor
- Biodexa Pharmaceuticals
Colorectal Polyp
The Impact of Traction Assisted ESD on Procedural Time and Outcome
The aim of this study is to evaluate the role of traction assisted ESD in comparison to traditional ESD on procedural time and outcome in patients with large, non pedunculated colorectal polyps.
- Trial name
- ESD (NCT03180788)
- Testing
- Traction assisted ESD, Traditional ESD
- Where
- Sweden
- Sponsor
- Region Skane
Colonic Polyp
Injured Submucosal Arteries After CSP for 10-19 mm Nonpedunculated Colorectal Polyps.
Cold polypectomy has the advantages of simple operation, less time-consuming and fewer complications. Guidelines have recommended cold snare polypectomy (CSP) to resect small polyps sized <9 mm.
- Trial name
- NCT05930041
- Testing
- Experimental CSP, Active Comparator HS-EMR
- Where
- Japan
- Volunteers
- 124 people
- Sponsor
- Showa Inan General Hospital
Familial Adenomatous Polyposis
Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis
Colorectal cancer (CRC) is a leading cause for cancer related mortality in the western world with a lifetime risk of 6%. Etiology is complex, while genetic background significantly affects the risk.
- Trial name
- FAP (NCT04454151)
- Testing
- Azithromycin Tablets
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colorectal Neoplasms
Artificial Intelligence for Diminutive Polyp Characterization
Artificial intelligence is a promising tool that may have a role in characterizing colon epithelial lesions (CADx), helping to get a reliable optical diagnosis regardless of the endoscopist experience.
- Trial name
- NCT05391477
- Testing
- GI-Genius artificial intelligence
- Where
- Spain
- Volunteers
- 643 people
- Sponsor
- Hospital Universitario La Fe
Large Bowel Polyp
Dutch National Prospective EMR Cohort
A Prospective Study: Longterm Follow Up until S2 (2nd surveillance) at 18 months after EMR for Large Flat/Sessile Colonic Polyps.
- Trial name
- DN-PEC (NCT03545061)
- Where
- Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Precancerous Condition
Biological, Genetic, and Lifestyle Risk Factors for Developing Colorectal Adenomas or Polyps in Participants Undergoing Colonoscopy
RATIONALE: Collecting and storing samples of tissue, blood, and other body fluids to test in the laboratory and gathering information about health and lifestyle from participants may help doctors learn more about cancer risk…
- Trial name
- NCT00625066
- Testing
- biologic sample preservation procedure, cytology specimen collection procedure, medical chart review
- Where
- 4 sites in United States
- Volunteers
- 8,108 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Intestinal Polyps
Comparison of Narrow Band Imaging With or Without Magnifying Colonoscopy
The aim of this study is to evaluate the usefulness of magnifying colonoscopy with narrow band imaging.
- Trial name
- NCT01577875
- Testing
- NBI with magnification
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Seoul National University Hospital
Colonic Polyps
Evaluation of Computer-assisted, Non-cathartic CT Colonography
The purpose of this study is to evaluate the performance of a non-cathartic, computer-assisted form of CT Colonography (Virtual Colonoscopy) for detection of pre-cancerous colon polyps in a group of asymptomatic screening…
- Trial name
- ncCTC (NCT01200303)
- Testing
- non-cathartic CTC
- Where
- 3 sites in United States
- Volunteers
- 605 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Artificial Intelligence
Using AI-assisted Optical Polyp Diagnosis for Diminutive Colorectal Polyps
This is a prospective study that is the first to implement resect and discard and diagnose and leave strategies in real-time practice using stringent documentation and adjudication by 2 expert endoscopists as the gold standard.
- Trial name
- AI-OD (NCT06059378)
- Testing
- Artificial intelligence-assisted classification (CADx)
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Polyps
Prospective Comparison of Cold Polypectomy and Conventional Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
1. Background: The ideal method to remove small colorectal polyps in patients who are taking antithrombotic agents is unknown. 2.
- Trial name
- NCT01553565
- Testing
- Cold polypectomy
- Where
- Japan
- Volunteers
- 160 people
- Sponsor
- Showa Inan General Hospital
Polyps of Colon, Polyps
Cold Snare Endoscopic Mucosal Resection (C-EMR) Versus Hot Snare Endoscopic Mucosal Resection (H-EMR) for Large Colorectal Polyps (10-20 mm)
OBJECTIVES The aim of the study is to compare the efficacy of cold snare EMR versus hot snare EMR for non-pedunculated polyps 10-20mm in size with respect to complete resection rates and adverse events.
- Conditions
- Polyps of Colon, Polyps, Polyp Intestine
- Trial name
- NCT06180798
- Testing
- cold snare endoscopic mucosal resection (C-EMR), Hot snare endoscopic mucosal resection (H-EMR)
- Where
- India
- Volunteers
- 330 people
- Sponsor
- Asian Institute of Gastroenterology, India
Colorectal Cancer, Adenomatous Polyps
Liquid Biopsy Based Multiomics Study for Colorectal Cancer Early Screening
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed liquid biopsy based multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo) for detecting advanced neoplasia…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- COLO-LIMULOID (NCT06258434)
- Testing
- multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Colonic Polyp
Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps).
- Trial name
- NCT01062035
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colonic Polyp, Colorectal Adenoma
Clinical Trial Evaluating External Evaluation and Training on the Incomplete Resection (POLIPEVA Study)
Introduction It has been shown that some quality indicators in endoscopy can be improved through educational interventions. There are marked differences in the proportion of incomplete polypectomies among endoscopists.
- Conditions
- Colonic Polyp, Colorectal Adenoma, Colorectal Cancer
- Trial name
- POLIPEVA (NCT04636619)
- Testing
- Colonic polypectomy, Online training course
- Where
- Spain
- Volunteers
- 1,920 people
- Sponsor
- Hospital del Rio Hortega