Clinical trials: Polypharmacy Patients
Polypharmacy, Dementia
A Patient-facing Tool to Reduce Opioid-Psychotropic Polypharmacy in People Living With Dementia (PLWD)
The goal of this project is to address central nervous system-active polypharmacy (CNS polyRx) in people living with dementia (PLWD) through focus groups and an educational intervention.
- Trial name
- NCT05628181
- Testing
- Educational nudge intervention
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- University of Michigan
Adherence, Patient, Stroke, Ischemic
Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients
Primary objective of the MAAESTRO trial is to evaluate the impact of an educational and reminder-based intervention on the adherence of stroke patients to DOACs.
- Trial name
- MAAESTRO (NCT03344146)
- Testing
- Medication intake reminders, Pillbox use and counselling
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- University Hospital, Basel, Switzerland
Drug Usage
Cooperation for Better Treatment of Polypharmacy in the Community
The elderly population today relies heavily on medication consumption. While there are cases where using multiple medications is necessary and reasonable, it also increases the risk of inappropriate treatment and adverse drug…
- Trial name
- NCT06020391
- Testing
- Collaborative drug review
- Where
- Norway
- Volunteers
- 139 people
- Sponsor
- Oslo University Hospital
Polypharmacy
Measuring the Impact of an Interdisciplinary Polypharmacy Clinic Within a Patient-centered Medical Home
Title: Measuring the impact of an interdisciplinary polypharmacy clinic within a patient-centered medical home Objectives: The primary objective of this project will be to track the types of interventions made in an…
- Trial name
- NCT02077725
- Testing
- interdisciplinary polypharmacy clinic visit
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Polypharmacy
A Digital Tool to Help Doctors and Pharmacists Prescribe Medicines More Safely for Older Adults in Oman
This is a prospective, multi-phase interventional study evaluating the clinical utility and efficacy of POLYMED-a bilingual (Arabic/English) web-based, explainable-AI medication risk calculator-on optimizing geriatric medication…
- Trial name
- POLYMED (NCT07840222)
- Testing
- OPIP Score Calculator (Oman Potentially Inappropriate Prescribing Risk Score)
- Volunteers
- 400 people
- Sponsor
- Oman Ministry of Health
Gastrointestinal Hemorrhage, Diabetes Complications
Therapeutic Conflicts and Multimorbidity
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or…
- Conditions
- Gastrointestinal Hemorrhage, Diabetes Complications, Multimorbidity
- Trial name
- NCT02928939
- Testing
- drug-drug or drug-disease interaction
- Where
- Switzerland
- Volunteers
- 1,101 people
- Sponsor
- University of Zurich
Frail Elderly Syndrome
Subjective Factors of Polymedication in the Elderly: a Qualitative Study of the Perceptions of Patients, Relatives and Referent Physicians.(DOSAGE)
The DOSAGE Study is a qualitative transversal study aiming to describe and understand the subjective factors of polymedication in the elderly population (75 years old and more), defined as 10 simultaneous drugs.
- Trial name
- DOSAGE (NCT03309228)
- Testing
- individual interviews
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Healthy
Rationalisation of Polypharmacy in the Elderly by the RASP Instrument
The aim of this study is to determine whether a clinical pharmacist using the RASP list (RASP = Rationalisation of home medication by an adjusted STOPP-list in older patients; STOPP = Screening Tool of Older Persons' potentially…
- Trial name
- RASP (NCT01513265)
- Testing
- Pharmaceutical care plan, mostly based on the RASP
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Diseases
Deprescribing Intervention for Patients With Chronic Kidney Disease
Chronic Kidney Disease (CKD) is recognized as a leading health problem globally. It is associated with multiple consequences such as cardiovascular diseases, infections, reduced cognitive function, and higher mortality rates.
- Trial name
- NCT06324045
- Testing
- Deprescribing
- Where
- Qatar
- Volunteers
- 424 people
- Sponsor
- Hamad Medical Corporation
Elderly (People Aged 65 or More), Polypharmacy (People Under Treatment With 5 or More Drugs)
Inappropriate Prescription in Elderly and Polypharmacy Patients in Primary Care (PHARM-PC) Trial
PHARM-PC study is based on identify potentially inappropriate prescriptions (PIP) and delivery therapeutic appropriateness recommendations from the pharmacist to the physician and about drugs prescribed for elderly and…
- Trial name
- PHARM-PC (NCT02224833)
- Testing
- Pharmacist intervention
- Where
- Spain
- Volunteers
- 549 people
- Sponsor
- Hospital Comarcal de Inca
Polypharmacy
Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management
The investigators will link community pharmacy and primary care practices via a shared electronic health record to improve medication therapy management for older patients taking complex prescription (Rx) regimens.
- Trial name
- TEAM (NCT04575155)
- Testing
- TEAM Strategy
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Northwestern University
Schizophrenia, Schizoaffective Disorder
Conversion to Antipsychotic Monotherapy
This is a 12-week, with a 32-week follow-up, rater-blind, randomized controlled trial to determine whether patients with chronic schizophrenia or schizoaffective disorder receiving two different antipsychotics simultaneously will…
- Trial name
- MOPE (NCT01368458)
- Testing
- Conversion to Antipsychotic Monotherapy
- Volunteers
- 24 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Heart Failure
Feasibility of Pharmaceutical Interventions in Elderly Heart Failure Patients.
Heart failure therapies (e.g. beta blockers) have been successful in decreasing mortality rates, as well as diminishing hospitalizations.
- Trial name
- RASP-HF (NCT02149940)
- Testing
- heart-failure related pharmaceutical intervention
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Multimorbidity
A New Organisation of Clinic for Multimorbidity and Polypharmacy
The purpose of this study is to investigate: 1) the implementation and 2) the effects of an outpatient program for patients with complex multimorbidity.
- Trial name
- NCT06735339
- Testing
- Clinic for Multimorbidity
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Central Jutland Regional Hospital
Eligible Patients Are Aged 65 Years or More Admitted to One of the Five Medicines for Older People Wards, Who Have ACB Score of 3 or More
The Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burden Among Hospitalised Older Patients
The feasibility and acceptability of a collaborative deprescribing intervention to reduce anticholinergic burden among hospitalised older patients
- Trial name
- DART (NCT07599735)
- Testing
- Patients will receive a collaborative deprescribing intervention
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Southampton
Fall, Fall Injury
A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patients
Falls in older adults represents a growing public health challenge. The use of certain medication is recognized as an important modifiable risk factor for falls.
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- ADFICE_IT (NCT05449470)
- Testing
- CDSS, Patient Portal
- Where
- 10 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs)
Impact of Pharmacotherapy Optimization in Polymedicated Lebanese Older Adults in Primary Health Care Centers
Why are the researchers doing this study? Many older adults take five or more medicines every day. Some of these medicines may no longer help them. Some may even cause harm, such as falls, confusion or tiredness.
- Conditions
- Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs), Primary Health Care, Social Determinants of Health (SDOH)
- Trial name
- PHARMACT-PHC (NCT07866677)
- Testing
- Structured pharmacotherapy optimization, Usual Care
- Where
- Lebanon
- Volunteers
- 452 people
- Sponsor
- National Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB)
Multimorbidity, Polypharmacy
The Interprofessional Medication Assessment for Older Patients
The objective of this pragmatic multi-center randomized controlled trial is to test the effectiveness of interprofessional medication assessment in older patients needing home care due to their diseases or decreased functional…
- Trial name
- NCT02398812
- Testing
- Medication assessment and treatment plan based on it
- Where
- 5 sites in Finland
- Volunteers
- 514 people
- Sponsor
- East Savo Hospital District
Prevention, Benzodiazepine Dependence
Electronic Deprescribing Tool for the Prevention of PIP
This study is a cluster randomized control trial aimed to measure the effectiveness of an educational knowledge transfer intervention to prescribers on the discontinuation of two targeted classes: Benzodiazepines…
- Trial name
- NCT03192514
- Testing
- Electronic Deprescribing tool
- Where
- Portugal
- Volunteers
- 280 people
- Sponsor
- University of Beira Interior
Multimorbidity, Polypharmacy
MultiPAP Plus: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy
This study assesses the effectiveness of a complex intervention in young-old patients with multimorbidity and polypharmacy aimed at improving physician drug prescription in primary care, measured by hospitalization-mortality at…
- Conditions
- Multimorbidity, Polypharmacy, Comorbidities and Coexisting Conditions, Clinical Decision-Support Systems
- Trial name
- MultiPAP Plus (NCT04147130)
- Testing
- MultiPAP Plus, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 1,162 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud