Clinical trials: Polyphenols
Osteopenia, Sarcopenia
Olive Oil Polyphenols, Vitamin D, Docosahexaenoic Acid (DHA) and Locomotor Function (PolivD3)
The present project hypothesizes that the potential protective effect of olive oil relies on its polyphenols profile (quality and quantity) and that it may be synergistic to other food components.
- Trial name
- PolivD3 (NCT01828944)
- Testing
- olive oil
- Where
- 2 sites in France
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Lesieur
Overweight, Obesity
Evaluation of a New Orange-Based Beverage Enriched With Polyphenols in Adult Humans
The purpose of this study is to evaluate the effects of a new orange juice-based beverage enriched in fiber and selected phenolic compounds (mainly flavanones) on features of metabolic syndrome and cardiovascular disease risk…
- Trial name
- BIONAOS (NCT01290250)
- Testing
- Orange juice based beverage enriched in polyphenols
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- The Coca-Cola Company
Pollution; Exposure
Effect of an Oral Acerola Juice Powder on Skin Beauty Parameters in Women Exposed to Environmental Stresses
The study is being conducted to evaluate the efficacy and the safety of an oral acerola-based product on skin ageing parameters.
- Trial name
- NCT07229131
- Testing
- Acerola Juice Powder 1200 mg/day, Acerola Juice Powder 600 mg/day
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Diana SAS
Prediabetic State, Dysglycemia
Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk
This clinical study aims to investigate the effects of TOTUM-63, a mix of 5 plant extracts, consumed at the daily regimen of three times per day, on cardiometabolic health and gut microbiota profile in overweight-obese…
- Conditions
- Prediabetic State, Dysglycemia, Overweight and Obesity
- Trial name
- NCT05369585
- Testing
- TOTUM-63
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valbiotis
IBS - Irritable Bowel Syndrome
Effects of a Combination of Polyphenol-rich Extracts, Prebiotics, and Hydrolyzed Fiber on the Quality of Life of Patients With Irritable Bowel Syndrome (IBS)
The aim of the study is to demonstrate a beneficial effect in reducing symptoms that negatively affect the quality of life of IBS patients, and to demonstrate a positive effect on inflammatory and intestinal function markers.
- Trial name
- NCT05990764
- Testing
- Probiotic, Prebiotic, Polyphenol-rich Extracts, Probiotic, Prebiotic
- Where
- Poland
- Volunteers
- 48 people
- Sponsor
- AronPharma Sp. z o. o.
Cardiovascular Risk Factors
Study on Effects of a Dairy Product Based on Polyphenols and Enriched With Vitamins B6, B9 and B12 on Some Cardiovascular Factor of Risk
We put forward that polyphenols and vitamins have a cardiovascular prevention effect for subject with cardiovascular risk.
- Trial name
- NCT00706888
- Testing
- Vitamins B6, B9 and B12 and polyphenols
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Elvir SAS
Vasodilation, Exercise
Acute Effect of Polyphenols Supplementation on Endothelial Function and Exercise Related Markers, in Physically Active Healthy Volunteers.
To evaluate the effect of acute polyphenols supplementation on vasodilation and related markers along with exercise related markers (notably performance, respiratory exchanges, perceived exertion), before, during and after a…
- Conditions
- Vasodilation, Exercise, Healthy Adults
- Trial name
- PolypOxy (NCT07518758)
- Testing
- Oral administration
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Nexira
Exercise Performance
The Effect of a Citrus Extract on Exercise Performance in Moderately Trained Athletes
In this study, the effect of citrus extract on exercise performance will be investigated. The study consists of three groups: one group will receive a high dose citrus extract, one group will receive a low dose citrus extract and…
- Trial name
- NCT03044444
- Testing
- citrus extract
- Where
- Netherlands
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- BioActor
Gut Health
A Study to Evaluate the Effects of a Butyrate-Polyphenol Formulation on Gut Health and Associated Symptoms
The purpose of the study is to evaluate the efficacy of a butyrate/polyphenol formulation on modulation of the gut microbiome and gastrointestinal symptoms using questionnaires in individuals with self-reported gastrointestinal…
- Trial name
- NCT07371975
- Testing
- Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
NAFLD, MASLD
Determination of Biological Activity of Enriched Serum Following TOTUM-448 Consumption
Dietary intakes of saturated fatty acids remain well above nutritional recommendations for most European countries. This may progressively lead to a pro-inflammatory context and the alteration of lipid metabolism in the liver.
- Conditions
- NAFLD, MASLD, Mild Inflammatory Context
- Trial name
- CnC-TOTUM448 (NCT06047847)
- Testing
- TOTUM-448
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Skill Performance, Soccer Performance
Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players
This study of soccer skill performance has three objectives: 1. Compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision, passing speed and accuracy, and sprint speed during a full simulated…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT05547204
- Testing
- Beverage
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy
Coffee Polyphenols Antioxidants
Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood.
- Trial name
- NCT01832662
- Testing
- coffee, maltodextrin enriched with caffeine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Eye Abnormalities
Effects of a Combination of Polyphenol-rich Extracts on the Protection of Retinal Cells Against Blue Light in the Prevention of Ocular Diseases
The aim of the study is to confirm that daily supplementation with a product containing a standardized combination of polyphenol-rich extracts has a protective effect against potential blue-light-induced damage to retinal cells.
- Trial name
- NCT06004570
- Testing
- Complex product, Polyphenol-rich extracts
- Where
- Poland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- AronPharma Sp. z o. o.
Skill Performance, Soccer Performance
Influence of Coffeeberry Ingestion on Soccer Skill Performance
The study of soccer skill performance has 3 objectives. Objective 1 is to compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision and passing and shooting speed and accuracy compared to…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT04181619
- Testing
- Coffeeberry beverage, Comparator beverage
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Anthocyanins
Intestinal Inflammatory and Metabolic Responses to a High Fat Meal and Plant Polyphenol Blend
This study will investigate the beneficial effects of supplementation with a plant polyphenol blend rich in anthocyanins on parameters of inflammation and metabolic responses following a challenge with a high-fat (HF) meal.
- Trial name
- NCT03309982
- Testing
- Plant polyphenol blend
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pharmanex
No Disease
Efficacy of Polyphenols From Milk and Dark Chocolate
Dark chocolate is one of the richest sources of polyphenols though it has been hypothesised that the bioavailability and therefore probably the bioefficacy of epicatechin from milk chocolate was reduced compared to dark.
- Trial name
- NCT00513344
- Testing
- Dark Chocolate, Milk Chocolate, Control (polyphenol-free) "Chocolate"
- Where
- Switzerland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Effect of Red Grape Cells (RGC) Powder Consumption on Measures of Aerobic Fitness and Mood
This is a 3-arm double blind placebo controlled study to investigate the effect of Red Grape Cell (RGC) powder containing all the matrix of polyphenols that can be found in red grapes.
- Trial name
- NCT01832584
- Testing
- RGC
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fruitura Bioscience Ltd.
Healthy Subjects, Pre-diabetes
Red Raspberry Polyphenols on Gut Microbiome
The primary objective aims are to assess the effects of regular consumption of red raspberries (RRB) with and without fructooligosaccharide (FOS) on the composition of the gut microbiota after 4 week intake and in parallel…
- Trial name
- RRB2 (NCT03049631)
- Testing
- Raspberry and fructooligosaccharide, Raspberry
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Atopic Dermatitis (AD)
Efficacy Study of a Repairing Cream in Atopic Dermatitis
The application of DermControl®, a repair cream based on hyaluronic acid, sh-oligopeptide-1 and polyphenols, in combination with topical corticosteroids, could help to improve epidermal barrier function in patients with atopic…
- Trial name
- NCT07742241
- Testing
- Dermcontrol, cream based on hyaluronic acid and sh-oligopeptide-1
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Instituto de Investigacion Biotecnologica, Farmaceutica y Medicamentos Huerfanos, S.L.
Diabetes Type 2
A Comparison Chocolate With and Without High Cocoa Solids in Patients With Type 2 Diabetes in a Randomised Clinical Trial
Type 2 diabetes is being acknowledged as a potential public health time bomb, whose incidence is predicted to double over the next 10 years in the UK, associated with the rise in obesity and increasing sedentary lifestyles.
- Trial name
- NCT01617603
- Testing
- Cocoa Polyphenols
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- Société des Produits Nestlé (SPN)