Clinical trials: Polyphenols
Type 2 Diabetes
Cocoa Polyphenols and Postprandial Metabolism in Type 2 Diabetes
This study aims to investigate the postprandial effects of cocoa supplementation in glucose and lipids, and surrogate markers of atherosclerosis in patients with type 2 diabetes.
- Trial name
- NCT01886989
- Testing
- Cocoa polyphenols
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Arpita Basu
Healthy
Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans
The objectives of this study are to i) describe the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetic parameters of selected dietary (poly)phenols in humans; and ii) to compare the ADME and…
- Trial name
- NCT03194620
- Testing
- Thearubigins, Theaflavins, Procyanidin Dimer B2 (DB2)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Mental Energy, Physical Performance
Dose Effect of a Plant Extract on Fatigue
Test the short-term effects of the acute consumption of two separate beverages containing different concentrations of polyphenols, a beverage containing 75 mg of caffeine and a flavored placebo beverage on mental energy and…
- Trial name
- NCT03870126
- Testing
- Flavored beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Gut Health
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
The purpose of this study is the assess the effectiveness and safety of a Butyrate formulation and a Butyrate + Polyphenol formulation on gut health, permeability and associated symptoms
- Trial name
- NCT06419231
- Testing
- Butyrate Formulation, Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Overweight or Obesity, Healthy
Berries, Inflammation, and Gut Microbiome
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations…
- Trial name
- NCT04100200
- Testing
- Mixed berries, FOS, Control
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
GI Health, Microbial Composition
Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition
The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and greater number and diversity of non-beneficial…
- Trial name
- NCT02743195
- Testing
- Polyphenol/prebiotic blend
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Nutrition, Absorption
Bioavailability From Chickpea Meals in Ileostomists?
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells.
- Conditions
- Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile
- Trial name
- NCT06921811
- Testing
- Intact chickpeas, Broken chickpeas
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Postprandial Period
Acute Effects of Blackcurrant and Citrus Polyphenol Extracts on Postprandial Glycaemia
Large postprandial glucose responses are associated with increased risk of chronic diseases, including diabetes and cardiovascular disease.
- Trial name
- Glu-FX (NCT03184064)
- Testing
- Blackcurrant extract (low dose), Citrus extract (low dose), Blackcurrant extract (high dose)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Lucozade Ribena Suntory
Overweight
Whole Grain Polyphenol Bioavailability and Effects on Health
Whole grains (WG) contain numerous physiologically bioactive compounds, a key group being polyphenolic compounds such as ferulic acid (FA).
- Trial name
- NCT01293175
- Testing
- Whole grains
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy
The Effect of Meat and Food Drived Polyphenols on Oxidize LDL Level
The postprandial increase in MDA level following meat meal could cause modification to LDL particles in healthy volunteers. Co-consumption of food drived polyphenols with the meat will result in a significant decrease in LDL…
- Trial name
- NCT01389492
- Testing
- frozen meat cutlets meal, meat meals
- Where
- Israel
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Diabetes, Insulin Resistance
Glycemic Index and Polyphenol Bioavailability of Potatoes
The purpose of this study is to determine the glycemic index of four varieties of potatoes and to determine the bioavailability of polyphenols contained in these potatoes.
- Trial name
- GI (NCT01053793)
- Testing
- Glycemic response to different varieties of potatoes
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guelph Food Research Centre
Healthy
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students
Available literature suggests that flavanols-rich foods, and more especially monomeric flavanols-rich foods such as grape, can have an acute effect on cognitive functions via different mechanisms such as cerebral blood flow…
- Trial name
- NCT03508206
- Testing
- SBRP
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Overweight
Bioavailability, Pharmacokinetic and Mechanistic Study of Sinetrol® Xpur, a Polyphenol-rich Ingredient
The purpose of the study is to investigate the metabolization and the bioavailability of bioactive compounds from Sinetrol® Xpur, a polyphenol-rich ingredient, during a 16-week long chronical supplementation.
- Trial name
- NCT03823196
- Testing
- Verum900, Verum1800
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fytexia
Obesity & Overweight, Healthy Adult
Vitis Intervention Trial in Substrate Metabolism
Obesity is associated with reduced metabolic flexibility (MetFlex), the capacity to shift between carbohydrate and lipid oxidation in response to nutrient availability.
- Trial name
- VITIS (NCT07800988)
- Testing
- Freeze-Dried Whole Grape Powder
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy, Normal Weight
Olive Oil Polyphenols and Cardiovascular Health Biomarkers
The purpose of this research is to investigate whether consuming two different kinds of olive oil will change risk factors related to cardiovascular disease, including levels of good and bad cholesterol, levels of inflammation…
- Conditions
- Healthy, Normal Weight, Overweight, Obese
- Trial name
- NCT04149288
- Testing
- High-polyphenol olive oil, Low-polyphenol olive oil
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Diseases
Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
Atherosclerosis, one major cause of morbidity and mortality worldwide, is a complex and multifactorial disease triggered especially due to high level of plasma lipids and that involves three mainly conditions: chronic…
- Trial name
- NCT02732223
- Testing
- Functional treatment, Control treatment
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Healthy Men
Effects of Cranberry Consumption in Vascular Function in Healthy Individuals
Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content.
- Trial name
- Cranberry (NCT02517775)
- Testing
- Cranberry 320, Cranberry 640, Cranberry 960
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Glucose Intolerance, Glucose Metabolism Disorders
Acute Study of Anthocyanin-rich Bilberry and Polyphenol-rich Apple Extracts on Postprandial Glycaemic Response
Strategies to control chronic postprandial hyperglycaemia by optimizing the functionality of foods would strengthen efforts to reduce the risk of developing T2D in the general population.
- Trial name
- NCT04004182
- Testing
- Fruit bar with addition of polyphenols
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Healthy Young
Cranberry (Poly)Phenol Consumption on Vascular Function
Epidemiological studies suggest that the consumption of (poly)phenols rich foods such as cocoa, tea, fruits and vegetables is associated with lower blood pressure, reduced cholesterol and decreased cardiovascular risk.
- Trial name
- NCT02764749
- Testing
- cranberry (poly)phenol containing supplement
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Menopause, Elevated Blood Pressure
Blueberries for Improving Vascular Endothelial Function in Postmenopausal Women With Elevated Blood Pressure
Postmenopausal women are at an increased risk of developing cardiovascular disease (CVD) largely due to accelerated aging-related modifications to vascular health following menopause.
- Conditions
- Menopause, Elevated Blood Pressure, Hypertension, Endothelial Dysfunction
- Trial name
- NCT03370991
- Testing
- Blueberry Powder
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Colorado State University