Clinical trials: Polytrauma Patients
Multiple Trauma
Effects of Omega-3 Fatty Acid Supplementation on Inflammatory Response in Multisystem Trauma Patients
This study will evaluate the effects of omega-3 fatty acid supplementation on inflammation in trauma patients. The main hypothesis is that such supplementation will reduce the presence of biomarkers of systemic inflammation, as…
- Trial name
- NCT01477697
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Emergencies, Trauma Injury
Pre-Hospital Zone 1 Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Injured Patients With Exsanguinating Sub-diaphragmatic Haemorrhage
It is unknown whether this evolved strategy (Pre-Hospital Zone I P-REBOA) is feasible and with an acceptable safety profile. This study will address this question, therefore informing the design of a prospective multicentre…
- Conditions
- Emergencies, Trauma Injury, Trauma, Multiple
- Trial name
- P-PRO (NCT04145271)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 4 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Multiple Trauma
Relationship Between Erythropoietin Administration and Stress Responses in Trauma Patients
The purpose of this study is to determine whether Erythropoietin decrease stress responses and inflammation in trauma patient.
- Trial name
- EPREX (NCT00622934)
- Testing
- erythropoietin
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Trauma, Trauma Injury
An Observational Study to Evaluate the Safety and Efficacy of Humacyte's HAV for Arterial Replacement or Reconstruction in Ukrainian Patients With Life or Limb-threatening Vascular Trauma
Humacyte provided HAVs as humanitarian aid to Ukraine. This retrospective observational study is designed to collect data from patients in whom the HAVs have already been implanted on a humanitarian basis between June 2022 and…
- Conditions
- Trauma, Trauma Injury, Trauma, Multiple, Trauma Blunt
- Trial name
- NCT05873959
- Testing
- HAV implantation
- Where
- 3 sites in Ukraine
- Volunteers
- 17 people
- Sponsor
- Humacyte, Inc.
Augmented Renal Clearance, Critical Illness
Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old
This single-center prospective cohort study conducted at the adult trauma ICU of the Montreal General Hospital (MGH) affiliated with the McGill University Health Centre (MUHC) aims to determine the incidence and associated risk…
- Conditions
- Augmented Renal Clearance, Critical Illness, Polytrauma, Traumatic Brain Injury
- Trial name
- NCT04766944
- Testing
- No intervention
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Polytrauma, Hypothermia
Forced Air Versus Endovascular Warming in Polytrauma Patients
Trauma is the leading cause of death in young adults, bleeding and infection are major concomitant problems. We test the hypothesis that fast, perioperative warming with an endovascular catheter versus forced air warming may…
- Trial name
- FAEWPP (NCT00555126)
- Testing
- Forced Air Warming, Warming with endovascular catheter + forced air warming
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Metabolism, Trauma
ImpACt of Very High Protein Content Enteral nUtrition Formulas on Critically Ill MUltipLe trAuma paTiEnts
This prospective observational randomized study aims to determine energy, protein intake and gastrointestinal tolerance while using enteral nutrition formulas with very high protein content and enteral nutrition formulas with…
- Conditions
- Metabolism, Trauma, Nutritional Deficiency, Protein Malnutrition
- Trial name
- ACCUMULATE (NCT05647135)
- Testing
- Medical food
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Limb Fracture
Impact of Continuous Regional Analgesia in Severe Trauma Patients
Regional analgesia, based on its physiological effects and efficacy, is used for optimal perioperative pain relief. However, for acute pain in multiple trauma patients in a critical condition, it has not been prospectively…
- Trial name
- ALRréa (NCT04546503)
- Testing
- Continuous Regional analgesia, Control Group
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Wounds and Injuries, Multiple Trauma
Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients
The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."
- Conditions
- Wounds and Injuries, Multiple Trauma, Disorder of Fluid Balance
- Trial name
- NCT01270854
- Testing
- Plasmalyte A, Normal Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, Davis
Patients Undergoing Esophagectomy, Patients With Severe Polytrauma
Evolution of the Lymphocyte Phenotype in Patients With Infection in Intensive Care Unit
Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly…
- Conditions
- Patients Undergoing Esophagectomy, Patients With Severe Polytrauma, Patients With Severe Neurological Lesion, Patients With Abdominal Infection
- Trial name
- REAPHEN (NCT06415474)
- Testing
- Lymphocyte Phenotyping Procedure
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Brest
Distal Radius Fracture, Multiple Trauma
Dynamic External Fixation in Treatment Distal Radius Fractures - Elderly Patients
A single center, parallel group, prospective, randomized clinical trial was conducted at the department of Hand Surgery, ABC (Andre, Bernardo, Caetano) Foundation University Hospital, Santo Andre, Brazil.
- Conditions
- Distal Radius Fracture, Multiple Trauma, Elderly Person Maltreatment
- Trial name
- NCT03154424
- Testing
- External fixation in treatment the distal radius fracture
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Acute Kidney Injury
Acute Kidney Injury in Pediatric Polytrauma Patients at Assiut University Trauma Unit: A Cross-Sectional Study on Incidence and Predictive Risk Factors
This study aims to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized pediatric patients and identify the risk, and severity of AKI.
- Trial name
- NCT06177886
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Trauma/Injuries
A Multi-center Clinical Study on the Status of Trauma Evaluating Ability in Patients With Multiple Trauma
Trauma is a major medical and public health problem facing all countries in the world today. Trauma is the leading cause of death worldwide for people under 45 years of age, and more than 5 million people die each year from…
- Trial name
- NCT03791333
- Testing
- injury severity score
- Volunteers
- 3,600 people
- Sponsor
- Peking University People's Hospital
Multiple Trauma/Injuries
Predictors of Mortality in Multiple Trauma Patients
Trauma is a public health concern that causes serious financial and medical burdens worldwide. According to the World Health Organization, 4.4 million people die from traumatic injuries each year which account for about 8% of…
- Trial name
- NCT07185529
- Testing
- Data of the patients were obtained from patient observation files and hospital information system database.
- Where
- Turkey (Türkiye)
- Volunteers
- 269 people
- Sponsor
- Melike Cengiz
Multiple Trauma
A Feasibility Study to Assess Pre Admission Status and Six Month Outcomes After Major Trauma
This study aims to assess the feasibility of obtaining details about a patients previous level of function from the patient of friend/relative, after they have been admitted an intensive care unit (ICU).
- Trial name
- NCT02917694
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Oxford University Hospitals NHS Trust
Traumatic Brain Injury, Multiple Trauma
Evolution of Oropharyngeal and Rectal Microbiota After Severe Traumatic Brain Injury
Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases.
- Trial name
- BBAX (NCT03965611)
- Testing
- Oropharyngeal swab, Rectal swab, Disability rating scale (DRS-F)
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oxidative Stress, Polytrauma
Oxidative Stress Expression and Metabolic Imbalance in Critically Ill Polytrauma Patients and the Implications of Antioxidant Therapy on Clinical Outcomes
Critically ill polytrauma patients have a number of physiological disorders secondary to trauma, such as systemic inflammatory response (SIRS), adult respiratory distress syndrome (ARDS), sepsis, oxidative stress (OS), and…
- Trial name
- OSPOL (NCT03218280)
- Testing
- Vitamin C
- Volunteers
- 100 people
- Sponsor
- Romanian Society of Anesthesia and Intensive Care
Patient Reported Outcome Measures, Recovery of Function
FIT Study (Functional Outcomes In Trauma Study)
Why? There is not much information in the UK on how well patients who sustain major trauma function afterwards. Major trauma is defined as significant injuries with a calculated 'injury severity score' (ISS) over 15.
- Conditions
- Patient Reported Outcome Measures, Recovery of Function, Rehabilitation, Disability Evaluation
- Trial name
- NCT04074382
- Testing
- Online Questionnaires, Qualitative Interviews
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Critical Illness
Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.
- Trial name
- NCT00318942
- Testing
- Crystalloids, Colloids
- Where
- 67 sites in Belgium, Canada and 3 more
- Volunteers
- 2,857 people
- Sponsor
- University of Versailles
Multiple Trauma, Sepsis
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from infectious complications and even sepsis.
- Conditions
- Multiple Trauma, Sepsis, Innate Immune Response, Disorder of Neutrophils
- Trial name
- POSEIDON (NCT03489577)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht