Clinical trials: Poor Glycemic Control
Type 2 Diabetes Mellitus
Evaluate Safety and Effectiveness of MBX-102 in Type 2 Diabetes Patients With Poor Glycemic Control on Metformin
To define the relative efficacy, safety and tolerability profiles of oral daily MBX-102 at daily doses of 400 and 600 mg vs. placebo and Actos® 30 mg (up-titrated to 45 mg after 8 weeks) when administered for up to 24 weeks in…
- Trial name
- NCT00814372
- Testing
- MBX-102, Actos, Metformin
- Where
- 26 sites in United States, India
- Volunteers
- 242 people
- Sponsor
- Gilead Sciences
Diabetes Mellitus, Type 1, Depressive Symptoms
Towards a Better Understanding of Diabetes Distress, Depression and Poor Glycaemic Control (DIA-LINK Study)
The DIA-LINK Study is a prospective observational study analysing longitudinal associations and mediating links between diabetes distress (DD), depressive symptoms (DS) and glycaemic outcomes in people with type 1 diabetes…
- Conditions
- Diabetes Mellitus, Type 1, Depressive Symptoms, Stress, Psychological, Glucose, High Blood
- Trial name
- DIA-LINK (NCT03811132)
- Testing
- Observation
- Where
- 2 sites in Germany
- Volunteers
- 208 people
- Sponsor
- Norbert Hermanns
Diabetes Mellitus, Type 2, Diabetes
Evaluation of Fuling Yunhua Granules and Dihuang Baoyuan Granules in Drug Naive Type 2 Diabetes Patients
The goal of this investigator-initiated clinical trial is to investigate the efficacy and safety of sequential therapy of Fuling Yunhua Granules (prescription A) and Dihuang Baoyuan Granule (prescription B) in the treatment of…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Type2diabetes
- Trial name
- NCT06575478
- Testing
- Fuling Yunhua Granules, Dihuang Baoyuan Granules
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Beijing Supreme Life Pharmaceutical Technology Co., Ltd.
Glucose Metabolism Disorders (Including Diabetes Mellitus), Diabetes Mellitus, Type 1
Flash Glucose Measure System and Continuous Subcutaneous Insulin Infusion Therapy in Poorly Controlled Diabetes Type 1 Patients
Patients with diabetes type 1 with poor glycemic control will be switched to insulin pump and FGM system (Flash Glucose Monitoring) during 6 months, correlated to the hypothesis that they could benefit from this intervention by…
- Trial name
- FREESTYLE (NCT03671161)
- Testing
- Insulin Pump and flash glucose monitoring
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Diabetes Mellitus, Non Insulin Dependent Diabetes Mellitus
ED Diabetes Screening and Outpatient Care - Aim 3
This goal of this NIH funded R01 study is to identify risk factors for not being able to follow-up for a new diagnosis of diabetes in the emergency department and improve linkage of these newly diagnosed patients to appropriate…
- Trial name
- NCT05899023
- Testing
- Telehealth Bridge Visits, Standard of Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Diabetes, Poor Glycemic Control
Insulin Pump Therapy and Continuous Glucose Monitoring in Diabetic Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients
The aims of this study are to assess the potential efficacy and safety of insulin pump to improve glycemic control in conjunction with continuous glucose monitoring (CGMS) for diabetic continuous ambulatory peritoneal dialysis…
- Trial name
- NCT01324557
- Testing
- CSII and MDI
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Guangdong Provincial People's Hospital
Type 2 Diabetes Mellitus
Study to Evaluate the Efficacy and Safety of PB-201 in Type 2 Diabetic Mellitus Patients With Poor Glycemic Control Via Metformin Hydrochloride Monotherapy
This is a Multi-center, Randomized, Double-Blinded, Parallel and Placebo-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of PB-201 in Type 2 Diabetic Mellitus Patients with Poor Glycemic Control via…
- Trial name
- NCT05326490
- Testing
- PB-201, Metformin hydrochloride
- Where
- China
- Volunteers
- 546 people
- Sponsor
- PegBio Co., Ltd.
T2DM (Type 2 Diabetes Mellitus)
Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control
The main objective of this study is to compare the efficacy and safety of the triple combination therapy of Met/SGLT-2i/GLP-1RA or other oral antidiabetic drugs in patients with type 2 diabetes exhibiting poor glycemic control.
- Trial name
- MESSAGE (NCT07244003)
- Testing
- Metformin, Triple Therapy of Other Oral Antidiabetic Drugs, ganagliflozin
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Diabetes Mellitus, Poor Glycemic Control
Periodontal Care and Glycemic Control in Diabetes
Diabetes is a prevalent and costly disease among users of VA care. Goals of diabetes care include the prevention and/or delay of complications via adequate glycemic control.
- Conditions
- Diabetes Mellitus, Poor Glycemic Control, Peridontal Disease
- Trial name
- NCT00012688
- Testing
- Doxycycline HCI 10mg po for 2 weeks, Ultrasonic scaling with 0.12% chlorhexidine gluconate
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes Mellitus
INTEGRA Study: Primary Care Intervention in Type 2 Diabetes Patients With Poor Glycaemic Control
The intensification of the management for the control of glycaemia and other risk factors in patients with type 2 diabetes (DM2) results in a reduction of diabetes-related complications.
- Trial name
- NCT02663245
- Testing
- Intervention 1, Intervention 2
- Where
- Spain
- Volunteers
- 564 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Type 2 Diabetes Mellitus, Poor Glycemic Control
A Study for Sufficient Acarbose Decreased Glucose Excursion in Type 2 Diabetic Patients
This is a multicentre observational study to investigate the improvement in glucose fluctuation of sufficient acarbose therapy on type 2 diabetes patient with high blood glucose fluctuation
- Trial name
- FLAT (NCT03805191)
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Qilu Hospital of Shandong University
Poor Glycemic Control, Quality of Life
Benefits of a Bolus Calculator in Pediatric Patients on Multiple Daily Insulin Injections
It it hypothesized that children and adolescents with type 1 diabetes, who are counting carbohydrates can achieve better metabolic control by concurrent use of the Accu-Chek Aviva Expert.
- Trial name
- NCT06141629
- Testing
- accu chek Aviva Expert, Accu Chek Aviva Nano
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus
The Guardcontrol Trial: Study to Assess if Type 1 Diabetics Can Improve Using the Real-time Values of Guardian RT
The objective of the study is to determine whether patients with poor glycemic control can improve metabolic control using the real-time values of the Guardian® RT compared to conventional self-monitoring blood glucose…
- Trial name
- NCT00111228
- Testing
- Guardian RT, SMBG only
- Where
- 8 sites in France, Germany and 5 more
- Volunteers
- 162 people
- Sponsor
- Medtronic MiniMed, Inc.
Prediabetes, Autonomic Nervous System Imbalance
Enhancing the Vagal Tone in Prediabetes Individuals
This is a 2-year course of study. A randomized control trial will be conducted, in which 90 prediabetes individuals will be recruited and randomly assigned them into the wait-list control group or experimental group to test the…
- Conditions
- Prediabetes, Autonomic Nervous System Imbalance, Poor Glycemic Control, Psychological Distress
- Trial name
- NCT03616275
- Testing
- HRV biofeedback
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Defense Medical Center, Taiwan
Randomized Controlled Trial, Diabetes Mellitus
Effect of Apple Cider Vinegar in Type 2 Diabetics
Background: apple cider vinegar is natural traditional health beneficial nutraceutical used for many aliments. Diabetes mellitus (DM) has been considered a globally major health problem and posing health burden on families and…
- Trial name
- NCT03593135
- Testing
- Apple Cider Vinegar and tablet Tagipmet (Metformin + Sitagliptin group), Water with Apple Cider vinegar flavor and tablet Tagipmet (Metformin + Sitagliptin group)
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Poor Glycemic Control
Food Design for Improved Day-long Glycaemic Regulation
The study focus is on the possible improvement in glucose tolerance at a second standardized meal that can be achieved when preceded by a test meal with a low GI and a high GP.
- Trial name
- NCT02876029
- Testing
- Reference, Test product
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Sleep Apnea, Type 2 Diabetes
Evolution With CPAP Treatment of a Cohort of Type 2 Diabetic Patients With Apnea-hypopnea Syndrome
The main purpose of this study is to measure the evolution of hemoglobin A1c level after treatment with CPAP in a cohort of type 2 diabetes mellitus patients with poor glycemic control and associated moderate or severe…
- Trial name
- DM2-CPAP (NCT01307566)
- Testing
- Continuous Positive Airway Pressure CPAP
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital de Granollers
Type 2 Diabetes Mellitus (T2DM)
A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
The main purpose of this study is to investigate the Efficacy and Safety of GZR18 Injection in Chinese Subjects with Type 2 Diabetes Mellitus and Poor Blood Glucose Control by Metformin Monotherapy or in Combination with…
- Trial name
- Optimum 2 (NCT06778967)
- Testing
- GZR18, semaglutide
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Type 2 Diabetes
Clinical Study of Retagliptin Phosphate Combined With Metformin in the Treatment of Type 2 Diabetes
Retagliptin phosphate tablet is a DPP IV inhibitor durg，study number is HR-SP2086-304. The primary purpose of the study is to evaluate the efficacy of the combination of Retagliptin phosphate and metformin compared with placebo…
- Trial name
- NCT05054842
- Testing
- Retagliptin phosphate tablets、metformin sustained-release tablets
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Diabetes Mellitus, Type 2
A Sub-study to LMF237A2302 to Assess the Effect of 24 Weeks Treatment With Initial Combination of Vildagliptin Plus Metformin
This study will evaluate the effects of treatment with vildagliptin and metformin as initial combination in newly diagnosed patients with type 2 diabetes who have very high levels of HbA1c and/or fasting plasma glucose.
- Trial name
- NCT00468039
- Testing
- vildagliptin + metformin
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Novartis