Clinical trials: Poorly Controlled Diabetes Mellitus
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Pilot Study Evaluating Safety of ExOlin® in Patients With Poorly Controlled Type 1 Diabetes
First in Human, pilot investigation An Open Label, Monocentric, Pilot Study Evaluating Safety of ExOlin® in Patients with Poorly Controlled Type 1 Diabetes with High Glucose Fluctuations, Prone to Severe Hypoglycemia
- Trial name
- Pilot'Ex (NCT05221359)
- Testing
- ExOlin®, Insulin aspart
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Defymed
Type 1 Diabetes
Incentives, Cognitive Training and Internet Therapy for Teens With Poorly Controlled Type 1 Diabetes
The overall goal of this project is to develop a novel family friendly intervention that will help teens with poor metabolic control of their type 1 diabetes increase and sustain daily self monitoring of blood glucose and lower…
- Trial name
- NCT01722643
- Testing
- MAxIM, Usual Care
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Diabetes Mellitus, Type 2
Opposing Step-by-step Insulin Reinforcement to Intensified Strategy
Primary objectives : To show the non inferiority in terms of efficacy (HbA1c) of insulin glargine plus metformin combined with 1 to 3 bolus of insulin glulisine introduced progressively (Arm 2) compared with insulin glargine plus…
- Trial name
- OSIRIS (NCT00174642)
- Testing
- Insulin Glargine, Insulin Glulisine, Metformin
- Where
- 18 sites in Belgium, France and 16 more
- Volunteers
- 811 people
- Sponsor
- Sanofi
Diabetes Mellitus
Incidence of Poorly Controlled Diabetes in Surgical Population
Our study aims to determine the incidence of undiagnosed and poorly controlled diabetes among surgical patients in Singapore using preoperative HbA1c as a screening tool.
- Trial name
- NCT04070963
- Testing
- HbA1C
- Where
- Singapore
- Volunteers
- 888 people
- Sponsor
- Singapore General Hospital
Diabetes Mellitus
IDegLira HIGH Trial
Basal-bolus insulin therapy is recommended for patients with poorly controlled type 2 diabetes (T2D) and HbA1c >9%. However, basal-bolus insulin is labor intensive and associated with increased risk of hypoglycemia, glycemic…
- Trial name
- NCT03737240
- Testing
- IDegLira, Insulin Degludec (U-100), Insulin Aspart
- Where
- 2 sites in United States
- Volunteers
- 145 people
- Sponsor
- Emory University
Type 2 Diabetes
Comparison of Technosphere® Insulin Versus Technosphere Powder (Placebo) in Insulin-Naive Subjects With Type 2 Diabetes Mellitus
Insulin-naive subjects with Type 2 Diabetes Mellitus who are sub-optimally controlled on either maximum tolerated dose of metformin or maximum tolerated dose of metformin plus one or two other oral anti-diabetic medications will…
- Trial name
- NCT01451398
- Testing
- Technosphere® Insulin, Technosphere Powder
- Where
- 76 sites in United States, Brazil and 2 more
- Volunteers
- 353 people
- Sponsor
- Mannkind Corporation
Type 1 Diabetes
Continuous Glucose Monitoring in Adolescents With Poorly Controlled Type 1 Diabetes
The purpose of this study is to see if children and adolescents with poorly controlled type 1 diabetes will benefit from using a continuous glucose monitor (CGM), a device that can be used to check blood sugars.
- Trial name
- NCT01586065
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus Type 2 With Periodontal Disease
Using AR Dental Care Training System in HE on Periodontal Status, Blood Sugar Control and QoL in Patients With T2DM
The aim of this study was to evaluate the long-term effectiveness of an AR dental care training in health education on periodontal status, blood sugar control and quality of life in patients with poorly controlled type 2…
- Trial name
- NCT05941468
- Testing
- AR Dental Care Training System
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Latent Tuberculosis Infection
Latent Tuberculosis in Type 2 Diabetes
The patients with poorly controlled DM underwent LTBI screening by using QuantiFERON (QFT). QFT-positivity predictors were evaluated.
- Trial name
- TB (NCT06874725)
- Testing
- Rifapentine and Isoniazid for 3 months, Isoniazid (INH) daily for 9 months
- Where
- Taiwan
- Volunteers
- 552 people
- Sponsor
- Taichung Veterans General Hospital
Glucose Metabolism Disorders, Diabetes Mellitus, Type 2
Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4…
- Conditions
- Glucose Metabolism Disorders, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Empagliflozin
- Trial name
- NCT06145360
- Testing
- Empagliflozin 10 MG, Insulin+Metformin+DPP4 inhibitor (DPP4I)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- SINA Health Education and Welfare Trust
Diabetes Mellitus, Type 2
Efficacy and Safety In Poorly Controlled Type 2 Diabetics
The purpose of this study is to gain safety and efficacy information in patients with type 2 diabetes, who have not previously taken any oral antidiabetic medications, and who have an HbA1c value of greater than or equal to 10%…
- Trial name
- NCT00044460
- Testing
- rosiglitazone
- Volunteers
- 142 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 1
Motivational Interview in Adolescents With Poorly Controlled Type 1 Diabetes
This study investigates the effect of motivational interviewing and intensive education on HbA1c values and glucose variability in poorly controlled adolescent T1D patients.
- Trial name
- NCT02637154
- Testing
- Motivational Interviewing, Standard Education
- Where
- 3 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Helsinki University Central Hospital
Diabetes
Advanced Comprehensive Diabetes Care for Veterans With Poorly-Controlled Diabetes
This study will determine whether Home Telehealth-based implementation of an evidence-based intervention targeting Veterans with persistent poorly-controlled diabetes can improve hemoglobin A1c, patient self-management, and…
- Trial name
- ACDC (NCT01778751)
- Testing
- Home Telehealth with Behavioral Education Component
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Diabetes type2
Impact of Short-term Intensive De-escalation Therapy on Long-term Regimen Simplification
Despite advances in diabetes management, many patients with type 2 diabetes in China fail to achieve optimal glycemic control. One of the possible reasons is associated with the delay in therapeutic decision making that lags…
- Trial name
- NCT03958591
- Testing
- CSII and thereafter combination therapy, followed up with wearable devices, CSII and thereafter combination therapy, Basal insulin treatment without wearables
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Yanbing Li
Type 1 Diabetes
Cross-over Study to Evaluate the Safety and Efficacy of Night Closed-loop Control Using the MD-Logic Automated Insulin Delivery System Compared to Sensor Augmented Pump Therapy in Poorly Controlled Patients With Type 1 Diabetes
The MD-Logic Automated Insulin Delivery System is intended for patients with type 1 diabetes mellitus for subcutaneous infusion of insulin and the continuous measurement of interstitial glucose to aid in the management of their…
- Trial name
- NCT02733211
- Testing
- MD- Logic Closed Loop System, sensor augmented pump therapy
- Where
- 2 sites in Germany, Israel
- Sponsor
- Rabin Medical Center
Diabetes Mellitus
A Clinical Trial Assessing the Impact of the Availability of Inhaled Insulin on Glucose Control
To assess the impact on glucose control by inhaled insulin in patients with type 2 diabetes who are not well controlled on 2 or more oral anti-diabetic agents
- Trial name
- NCT00134147
- Testing
- Inhaled Insulin
- Where
- 121 sites in United States, Canada and 5 more
- Volunteers
- 1,100 people
- Sponsor
- Pfizer
Diabetes Mellitus
Comparison of Glycemic Control With Smartphone Application
The study is aimed to determine if a smartphone application based weekly glucose monitoring by a care provider is superior to the routine home glucose monitoring by patients in poorly controlled type 2 diabetes mellitus who are…
- Trial name
- NCT05592860
- Testing
- Mobile application, Daily Diary
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
type1diabetes
Remote Digital Care Effects in Adolescents With Type 1 Diabetes
Pilot study to evaluate effects of an experimental additional remote digital care (TELEDUC-DIAB) to adolescents with poorly controlled type 1 diabetes using digital monitoring platform and educative app
- Trial name
- TELEDUC-DIAB1 (NCT05421715)
- Testing
- TELEDUC-DIAB
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Effect of Paired Testing to Poorly Controlled Chinese Diabetes on Glycemic Control and Self Care
This study aims is to evaluate the effect of introducing paired testing on actual testing frequency, glycemic control, psychosocial and behavioural aspects of poorly controlled diabetes patients in China.
- Trial name
- NCT02225691
- Testing
- Paired testing of blood glucose Accu-Chek®
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 6th People's Hospital
Type 2 Diabetes
GALLANT 7 Tesaglitazar Add-on to Sulphonylurea
This is a 24-week randomized double-blind, parallel-group, multi-center, placebo-controlled study of tesaglitazar (0.5 mg and 1 mg) given as add-on therapy to sulphonylurea in patients with type 2 diabetes, not adequately…
- Trial name
- NCT00251940
- Testing
- Tesaglitazar 0.5 or 1 mg, Glibenclamide 2.5, 5, 10 or 15 mg
- Where
- 84 sites in Australia, France and 8 more
- Volunteers
- 555 people
- Sponsor
- AstraZeneca