Clinical trials: Population Medicine
Rheumatoid Arthritis
A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune and chronic inflammatory disease that causes progressive damage to joints of the body, affecting the functional capacity.
- Trial name
- TERRA (NCT01430507)
- Testing
- Revamilast
- Where
- 36 sites in India, Philippines and 3 more
- Volunteers
- 406 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Medication Therapy Management, Estimated Cost Avoidance
Medication Therapy Management (MTM) for a Medicaid Managed Care Population Within Patient-Centered Medical Homes
The primary objective of this project is to determine the estimated cost avoidance (ECA) resulting from medication therapy management (MTM) interventions in a patient-centered medical home (PCMH).
- Conditions
- Medication Therapy Management, Estimated Cost Avoidance, MTM, Medication Management
- Trial name
- NCT05711771
- Testing
- medication therapy management
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Vascular Disease, Cerebrovascular Disorders
Using a Tailored Health Information Technology Driven Intervention to Improve Health Literacy and Medication Adherence
Although most patients admitted with acute coronary syndrome or acute ischemic stroke in South Asian countries receive these evidence-based treatments, their overall continuation in the outpatient phase of care remains low.
- Conditions
- Vascular Disease, Cerebrovascular Disorders, Ischemic Heart Disease, Coronary Artery Disease
- Trial name
- TalkingRx (NCT02354040)
- Testing
- Talking Rx
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Aga Khan University
Virus Diseases, RNA Virus Infections
Immunogenicity, Safety and Tolerability of a Plant-Derived Seasonal VLP Quadrivalent Influenza Vaccine in the Elderly Population
This is a multiple sites phase II trial, randomized, observer-blind, dose ranging, placebo-controlled study to evaluate the immunogenicity, safety, and tolerability of a single intramuscular injection of plant-based Seasonal VLP…
- Conditions
- Virus Diseases, RNA Virus Infections, Respiratory Tract Diseases, Respiratory Tract Infections
- Trial name
- NCT02236052
- Testing
- Non-adjuvanted low dose of quadrivalent VLP vaccine, Non-adjuvanted medium dose of quadrivalent VLP vaccine, Non-adjuvanted high dose of quadrivalent VLP vaccine
- Where
- 3 sites in Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Medicago
Mycoses, Neutropenia
Therapeutic Drug Monitoring (TDM) of Voriconazole and Correlation With CYP2C19 Genotype in Korean Populations
Voriconazole (VCZ), the antifungal drug active against Candida and Aspergillus is a substrate of CYP2C19, whose proportion of poor metabolizers is about ~20% in Asian population.
- Conditions
- Mycoses, Neutropenia, Bone Marrow Transplantation
- Trial name
- NCT00673348
- Where
- 2 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- The Catholic University of Korea
Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension (PAH)
The Impact of ERA Switching on Risk Stratification in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare, progressive, and potentially life-threatening disease characterized by pulmonary vascular remodeling, increased pulmonary vascular resistance, and right ventricular dysfunction.
- Conditions
- Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
- Trial name
- ACTION (NCT07013149)
- Testing
- Switch from Ambrisentan to Bosentan, Maintenance of Ambrisentan Therapy
- Where
- Brazil
- Volunteers
- 183 people
- Sponsor
- University of Sao Paulo General Hospital
Healthy
Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers
The purpose of this study is to evaluate the possibility of drug interactions before and after taking red ginseng or fermented-red ginseng by estimating metabolic rate of indicator drugs for cytochrome P450 and P-glycoprotein.
- Trial name
- NCT02056743
- Testing
- CYP cocktail, Fexofenadine 30mg, Red ginseng
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Cancer Pain, Cancer
PARASTOP - Paracetamol With Strong Opioids
Current guidelines recommend all people with cancer-related pain should be prescribed paracetamol, even those receiving high doses of strong pain killers (opioids) such as morphine.
- Trial name
- PARASTOP (NCT05051735)
- Testing
- Paracetamol
- Where
- 15 sites in Italy, Norway and 2 more
- Volunteers
- 204 people
- Sponsor
- Oslo University Hospital
HIV-1 Infection
Clinical Trial to Evaluate Drug-drug Interactions Between Darunavir/Cobicistat and Etravirine in Hiv- Infected Patients
This study aims to provide information about the safety and pharmacokinetic drug-drug interactions between darunavir/cobicistat (800/150mg QD) and etravirine (400mg QD) in HIV-infected patients, as well as evaluate the efficacy…
- Trial name
- NCT02818348
- Testing
- darunavir/cobicistat, etravirine
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Pneumonia, Pneumocystis Carinii, HIV Infections
A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP
To evaluate and compare the safety, tolerability, and effectiveness of long-term biweekly administration of 1 of 2 doses of aerosol pentamidine when used as a prophylactic agent in patients who have had multiple episodes of AIDS…
- Trial name
- NCT00002055
- Testing
- Pentamidine isethionate
- Where
- 4 sites in United States
- Sponsor
- Fisons
Diabetes Mellitus, Type 2
Effects of Nateglinide on Postprandial Glucose Excursion by Restoring Early Phase Insulin Secretion
A 3-week, multi-center, open-label, randomized, active-control, parallel-group study to compare effects of Nateglinide and Acarbose on postprandial glucose fluctuation in Chinese drug-naive patients type 2 diabetes mellitus…
- Trial name
- NCT01030952
- Testing
- Nateglinide, Acarbose
- Where
- 3 sites in China
- Volunteers
- 103 people
- Sponsor
- Novartis Pharmaceuticals
Arthritis, Rheumatoid
A Study of CNTO 136 (Sirukumab), Administered Subcutaneously, in Patients With Active Rheumatoid Arthritis Despite Disease-Modifying Antirheumatic Drug (DMARD) Therapy (SIRROUND-D)
The purpose of this study is to assess the efficacy of sirukumab as measured by the reduction of the signs and symptoms of rheumatoid arthritis (RA) and inhibition of radiographic progression in patients with active RA who are…
- Trial name
- NCT01604343
- Testing
- Sirukumab
- Where
- 156 sites in United States, Bulgaria and 16 more
- Volunteers
- 1,670 people
- Sponsor
- Janssen Research & Development, LLC
Refractory Epilepsy, Focal Epilepsy
Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia
Focal Cortical Dysplasias (FCDs) are neurodevelopmental disorders that represent a major cause of early onset drug-resistant epilepsies with cognitive and behavioral impairments, carrying a lifelong perspective of disability and…
- Conditions
- Refractory Epilepsy, Focal Epilepsy, Focal Cortical Dysplasia
- Trial name
- SPREAD (NCT03321240)
- Testing
- visual and quantitative SEEG signal analysis, Resective epilepsy surgery procedure
- Where
- 11 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Neck Pain, Chronic Low Back Pain
Group Acupuncture Therapy With Modified Yoga
Chronic pain is prevalent in the U.S., with impact on physical and psychological functioning as well as lost work productivity. Minority and lower socioeconomic populations have increased prevalence of chronic pain with less…
- Conditions
- Chronic Neck Pain, Chronic Low Back Pain, Osteoarthritis Pain
- Trial name
- GAPYOGA (NCT04296344)
- Testing
- Acupuncture Therapy Treatments, Yoga Therapy Sessions
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Common Cold
Herbal Medicine 'Eungyosan' and 'Samsoeum' for Common Cold
The investigators intend to conduct a multicenter clinical trial to verify the effectiveness and safety of the administration of 'Eungyosan(EGS)' and 'Samsoeum(SSE)' in cold patients.
- Trial name
- NCT04073511
- Testing
- Eungyosan, Samsoeum
- Where
- 4 sites in South Korea
- Volunteers
- 375 people
- Sponsor
- Korean Medicine Hospital of Pusan National University
Lung Diseases, Pulmonary Disease, Chronic Obstructive
An Investigational Drug Study In Patients With COPD (Chronic Obstructive Pulmonary Disease) (MK-0873-005)
This is a study to evaluate the effectiveness and tolerability of a once-daily oral medication (MK-0873) for the treatment of COPD (chronic obstructive pulmonary disease) to determine whether the study drug leads to an…
- Trial name
- NCT00132730
- Testing
- MK-0873 2.5 mg, MK-0873 1.25 mg, MK-0873 0.75 mg
- Volunteers
- 604 people
- Sponsor
- Merck Sharp & Dohme LLC
Colonic Neoplasms
Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation
A quality colonoscopy examination remains as the gold standard for colorectal cancer screening, but effective large bowel cleansing prior to colonoscopy is still not achieved in all cases that undergo the procedure.
- Trial name
- NCT01547130
- Testing
- Normal (0.9%) saline, HalfLytely
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Arya, Vijaypal, M.D., P.C.
Cervical Neoplasms
A Trial of Neoadjuvant Chemotherapy + Surgery vs. Surgery for Bulky Stage I/II Cervical Cancer
To investigate the clinical benefits of neoadjuvant chemotherapy for bulky stage I/II cervical cancer
- Trial name
- NCT00190528
- Testing
- neoadjuvant chemotherapy + radical hysterectomy, radical hysterectomy
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Haruhiko Fukuda
Childhood Obesity
Impact of Body Weight on the Immediate Health of the Pediatric Population
Objective: Obesity amongst children is a public health issue in the United States and is rising at an alarming rate. The purpose of this study is to determine if there is any correlation between At Risk body weight (overweight…
- Trial name
- NCT00267631
- Where
- United States
- Volunteers
- 5,392 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
HIV, Illicit Drug User
STRIBILD in Non-Nucleoside Resistant Patients (SINNR STUDY)
The SINNR study will evaluate the virologic efficacy (viral load <50 copies/mL)and safety of STRIBILD administered for 48 weeks to HIV-infected current or recent illicit drug users.
- Trial name
- SINNR (NCT02306577)
- Testing
- STRIBILD
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vancouver Infectious Diseases Centre
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