Clinical trials: Population Medicine
Prescription Medication Understanding
Writing: a Factor That Can Influence Understanding of Prescriptions in the Geriatric Population
Understanding prescriptions is a key factor in the therapeutic education and compliance of elderly patients with multiple medications.
- Trial name
- ROSA (NCT06855017)
- Testing
- create a pillbox day
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Participants, Pharmacokinetics
Comparing the Extent to Which Two Evolocumab Drug Products Are Made Available in the Body After a Single Subcutaneous Dose
The main objective of this trial is to evaluate the pharmacokinetics of two evolocumab drug products in healthy participants.
- Trial name
- NCT07422285
- Testing
- Evolocumab Drug Substance A, Evolocumab Drug Substance B
- Where
- 4 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Amgen
Infertility
Study to Investigate the Optimal Dose of Org 36286 to Induce Monofollicular Ovulation in Women With WHO Group II Anovulatory Infertility (P07016)
The objectives of this trial were to investigate the feasibility and the optimal dose of a single administration of Org 36286 to induce monofollicular ovulation in women with WHO Group II anovulatory infertility and to assess the…
- Trial name
- NCT00702585
- Testing
- Org 36286
- Volunteers
- 55 people
- Sponsor
- Organon and Co
Social Isolation, Loneliness
Intergenerational Program for Social Isolation and Loneliness in Older Adults Discharged From the Emergency Department
Social isolation and loneliness worsens older adults' risk of dementia, quality of life, and death as much as smoking. Older adults are more likely to use emergency services and are also more likely to experience social isolation…
- Conditions
- Social Isolation, Loneliness, Geriatric
- Trial name
- SIL (NCT05998343)
- Testing
- Intergenerational HOW R U?, Same-Generation Peer Support HOW R U?
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Glaucoma
Clinical Evaluation of Efficacy of SLT to Topical Medication in Lowering IOP
The purpose of this study is to compare Selective laser trabeculoplasty (SLT) and topical medications for initial treatment of open-angle glaucoma /Ocular Hypertension based on intraocular pressure reduction, treatment side…
- Trial name
- NCT01639807
- Testing
- Latanoprost, SLT
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Aurolab
Nosocomial Pneumonia (NP), Ventilator-associated Pneumonia (VAP)
A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia
The purpose of the study is to evaluate the effects of Ceftazidime-Avibactam compared to Meropenem for treating hospitalized adults with nosocomial pneumonia including ventilator-associated pneumonia
- Trial name
- NCT01808092
- Testing
- ceftazidim-avibactam (CAZ-AVI, experimental product), meropenem (active comparator)
- Where
- 123 sites in Argentina, Brazil and 24 more
- Volunteers
- 969 people
- Sponsor
- Pfizer
Epilepsy
A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic Medications
Evaluating efficacy \& safety of lacosamide versus Placebo in a blinded fashion as add-on Therapy for Primary Generalized Tonic-clonic (PGTC) seizures in subject 4 years of age or greater with idiopathic generalized epilepsy…
- Trial name
- VALOR (NCT02408523)
- Testing
- Lacosamide Tablet, Lasosamide Oral Solution
- Where
- 115 sites in United States, Australia and 20 more
- Volunteers
- 242 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Obese Adults, BMI/Body Composition
Precision Lifestyle Medicine Program for IFHAS Participants
The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who…
- Conditions
- Obese Adults, BMI/Body Composition, Cardiometabolic Risk, Cardiovascular Disease Risk
- Trial name
- NCT07742917
- Testing
- Precision Lifestyle Medicine Program, Standard IFHAS Care
- Where
- United Arab Emirates
- Volunteers
- 150 people
- Sponsor
- Institute for Healthier Living Abu Dhabi
Diabetes Mellitus, Type 2
Multiprofessional Approach in Diabetes Mellitus
OBJECTIVE: to verify the effectiveness of adopting the practice of educational groups in primary care and the multiprofessional role in the control of diabetes mellitus in adults.
- Trial name
- NCT04958980
- Testing
- Specific and educational guidelines on care for pathology (diabetes mellitus) according to each profession involved in the research
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leonardo Paroche de Matos
Arterial Hypertension, Dyslipidemias
Study of Adherence to Antihypertensive Drugs and Statins by Hair Analysis
The problem of adherence to long-term therapies has been known for years and occurs substantially in all countries, although with greater severity in developing countries.
- Conditions
- Arterial Hypertension, Dyslipidemias, Antihypertensive Drugs, Statins
- Trial name
- INNOVA (NCT05347823)
- Testing
- Hair analysis for drug concentration
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
HIV Infections, Adherence, Medication
Transmasculine One-on-One and Group Empowerment for Targeted HIV Reduction
Transgender masculine and gender diverse people who have sex with men (TMSM) have an increased risk of human immunodeficiency virus (HIV) and face unique barriers engaging in prevention services.
- Trial name
- TOGETHR (NCT06182280)
- Testing
- PrEP4T, LS4TM
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Hypercholesterolemia
Study of an Approved Drug With a Statin (a Medication That Lowers Cholesterol Levels) as Compared to Statin Therapy Alone in Patients With High Cholesterol (0653-040)
The purpose of this 6-week study is to compare the reduction in specific levels of cholesterol in patients with high cholesterol.
- Trial name
- NCT00092586
- Testing
- MK0653, ezetimibe, Comparator: statins
- Volunteers
- 2,904 people
- Sponsor
- Organon and Co
Healthy
Evaluation of the Pharmacokinetic Interaction of Steady State Tipranavir and Ritonavir or Tipranavir and Ritonavir With Single Dose Didanosine in Healthy Volunteers
Study to characterise the effects of concurrent tipranavir (TPV) and ritonavir (RTV) administration on the single dose pharmacokinetics of didanosine (ddI), to characterise the effects of single-dose ddI on the pharmacokinetics…
- Trial name
- NCT02251873
- Testing
- TPV + RTV (low dose), TPV + RTV (high dose), ddl
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Diabetes Type 2
Dulce Digital 2.0 - Innovative Diabetes Self-Management in the Digital Age
The proposed research, "Dulce Digital 2.0," will evaluate two mHealth adaptions of Project Dulce that are designed to improve digital health literacy, increase underserved individuals' capacity to access and engage with vital…
- Trial name
- Dulce Digital (NCT05416060)
- Testing
- Dulce Digital Text-Based Education, Project Dulce Telehealth, Project Dulce Live
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Scripps Whittier Diabetes Institute
Depressive Episodes, Bipolar I Depression
A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.
A clinical trial to study the efficacy and safety of an investigational drug in people with major depressive episodes associated with with Bipolar I disorder (bipolar I depression) Participants in the study will either receive…
- Trial name
- NCT05169710
- Testing
- SEP-4199 CR 200 mg, SEP-4199 CR 400 mg
- Where
- 89 sites in United States, Bulgaria and 4 more
- Volunteers
- 83 people
- Sponsor
- Sumitomo Pharma America, Inc.
Diabetes Mellitus, Type 2, Hyperglycemia
Safety and Efficacy Study of Empagliflozin and Metformin for 24 Weeks in Treatment Naive Patients With Type 2 Diabetes
This study will investigate the efficacy and safety of two doses (high and low) of empagliflozin in combination with metformin (500 mg and 1000 mg) administered twice daily in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01719003
- Testing
- Metformin 500 mg bid, Metformin 1000 mg bid, Empagliflozin low dose qd
- Where
- 190 sites in United States, Brazil and 19 more
- Volunteers
- 1,413 people
- Sponsor
- Boehringer Ingelheim
Hepatic Impairment, Healthy Volunteers
A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction
The purpose of this study is to understand the effects of liver functional impairment on the study medicine (PF-07081532). People with liver functional impairment may process the study medicine differently from healthy people.
- Trial name
- NCT05478603
- Testing
- PF-07081532
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Mild Cognitive Impairment, Alzheimer's Disease(AD)
Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild Cognitive Impairment and Prodromal Alzheimer's Disease
This study is a multicenter, randomized, double-blind, parallel-group, prospective confirmatory clinical trial designed to evaluate whether the Neuclare medical device can temporarily improve executive function (planning and…
- Trial name
- NCT07239310
- Testing
- Participants receive Neuclare Device while continuing their cognitive medication
- Where
- 7 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- Deepsonbio
Breast Cancer, Adherence, Medication
Small-group, Virtual Program for Improving Symptoms and Distress Related to Hormonal Therapy for Breast Cancer Survivors
The purpose of this study is to explore the feasibility and acceptability of a brief, virtual, group-based cognitive-behavioral intervention for breast cancer survivors taking hormonal therapy.
- Trial name
- STRIDE (NCT03837496)
- Testing
- STRIDE, Medication Monitoring Control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Acute Rhinosinusitis
Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
The purpose of this study is to determine whether the dry extract BNO 1016 is effective and safe in the treatment of acute rhinosinusitis in adults.
- Trial name
- NCT01146860
- Testing
- BNO 1016
- Where
- Germany
- Volunteers
- 386 people
- Sponsor
- Bionorica SE
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