Clinical trials: Population Medicine
Healthy
Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Bendavia™) in Healthy Adults
This is the first study of MTP-131 (Bendavia™) in humans. The objective of this study is to evaluate the safety, tolerability, and pharmacokinetics of escalating single intravenous infusion doses of MTP-131.
- Trial name
- NCT01115920
- Testing
- MTP-131 (Bendavia™)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mighty Therapeutics, Inc.
HIV Infections
Effect of Vaccination on Turnover of Lamivudine (3TC) Sensitive and Resistant Virus Populations in HIV-1-Infected Individuals
To ascertain whether the origin of plasma HIV-1-RNA following T cell activation represents the activation of latently infected cells or an increase in cells permissive for replacing viral mutants.
- Trial name
- NCT00001080
- Testing
- Influenza Virus Vaccine, Pneumococcal Vaccine, Polyvalent (23-valent), Lamivudine
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Statin, Cardiovascular Risk Factors
Role of Coronary CTA on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population
The primary objective of this study is to determine whether coronary computed tomography angiography (CCTA) -based coronary heart disease(CHD) prevention strategy improves lipid-lowering treatment and cardiovascular risk factor…
- Conditions
- Statin, Cardiovascular Risk Factors, Primary Prevention, Adherence, Medication
- Trial name
- RESPECT2 (NCT05725096)
- Testing
- Coronary Computed Tomography Angiography, Traditional cardiovascular risk stratification
- Where
- China
- Volunteers
- 3,400 people
- Sponsor
- Zhang longjiang,MD
COVID-19
Study to Evaluate the Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) Plus Standard Medical Treatment (SMT) Versus SMT Alone in Participants in Intensive Care Unit (ICU) With Coronavirus Disease (COVID-19)
The purpose of the study is to determine if a high dose of Intravenous Immune Globulin (IVIG) plus Standard Medical Treatment (SMT) can reduce all-cause mortality versus SMT alone in hospitalized participants with COVID-19…
- Trial name
- NCT04480424
- Testing
- GAMUNEX-C, Standard Medical Treatment
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Grifols Therapeutics LLC
Substance Abuse, Substance Dependence
Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
The purpose of the study is to determine whether interpersonal psychotherapy is effective for treating co-occurring depression and substance use among women prisoners.
- Conditions
- Substance Abuse, Substance Dependence, Depressive Disorder
- Trial name
- NCT00606996
- Testing
- Group interpersonal psychotherapy (IPT-G), Psychoeducation on co-occurring disorders (PSYCHOED)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Brown University
HIV Infections
Treatment Plan to Decrease Drug Exposure in HIV Infected Adolescents
This study will attempt to stimulate the immune system in HIV infected adolescents and young adults so that it can better control the HIV infection.
- Trial name
- NCT00067574
- Testing
- Structured treatment interruption
- Where
- 4 sites in United States
- Sponsor
- University of North Carolina, Chapel Hill
Hepatitis C, Diagnostic Self Evaluation
HCV Self-testing in Georgia
Self-testing with easy-to-use rapid diagnostic tests has been successfully used for diseases such as HIV. The availability of self-testing has been shown to increase testing rates and testing acceptability in diverse populations…
- Trial name
- NCT04961723
- Testing
- (OraQuick® HCV Self-Test
- Where
- 6 sites in Georgia
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Bowel Cleansing
Compound Sodium Picosulfate Granules for Bowel Preparation in Chinese Population
High-quality bowel preparation plays an important role in ensuring a safe and successful X-ray examination, endoscopy or some kinds of bowel surgeries.
- Trial name
- NCT04852120
- Testing
- No intervention
- Where
- 8 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Ferring Pharmaceuticals
Postabortion Care
Integrating Family Planning Into Postabortion Care
A descriptive post-intervention study designed to provide data to decision-makers at the Kenyan Ministry of Health, the Extending Service Delivery Project (ESD), and Pathfinder International about whether and how to scale-up the…
- Trial name
- NCT01020552
- Testing
- Provision of PAC job aids and provider training on the use of the job aids
- Where
- 8 sites in Kenya
- Volunteers
- 300 people
- Sponsor
- FHI 360
Malaria
Monitoring Pregnant Women for Antimalarial Drug Resistance
Annually, malaria affects an estimated 229 million people, causing 409,000 deaths (WHO 2019) mostly in Africa. Despite a substantial decline in malaria-related maternal and child deaths in recent years, progress in controlling…
- Trial name
- MIRANDA (NCT05072613)
- Testing
- Malaria screening
- Where
- Democratic Republic of the Congo
- Volunteers
- 6,833 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Acute Pain
Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar
The study is aimed to evaluate the analgesic efficacy of TRAM.HCl/DKP.TRIS 75mg/25mg oral fixed drug combination in comparison with TRAM.HCl /paracetamol 75mg/650mg in the treatment of moderate to severe acute pain.
- Trial name
- DAVID (NCT02777970)
- Testing
- Tramadol Hydrochloride/Dexketoprofen Trometamol, Tramadol Hydrochloride/Paracetamol
- Where
- 18 sites in Hungary, Italy and 3 more
- Volunteers
- 654 people
- Sponsor
- Menarini Group
Pulmonary Disease, Chronic Obstructive
The ENERGITO® 2 Study Compares 2 Inhaled Medicines for Chronic Obstructive Pulmonary Disease (COPD). One Medicine is a Combination of Tiotropium and Olodaterol (Stiolto®) Taken Using the Respimat® Inhaler and the Other Medicine is a Combination of Fluticasone and Salmeterol Taken Using the Diskus
The primary objective of the trial is to show superiority in lung function of once daily (2 inhalations) treatment with orally inhaled tiotropium+olodaterol fixed dose combination to twice daily (one inhalation) treatment with…
- Trial name
- NCT03240575
- Testing
- Tiotropium, Olodaterol, Fluticasone propionate
- Where
- 45 sites in United States
- Volunteers
- 302 people
- Sponsor
- Boehringer Ingelheim
Chronic Pain, Depression
Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression
The purpose of this study is to determine whether Integrative Medicine Group Visits (IMGV) are effective for treating patients with chronic pain and depression.
- Trial name
- IMGV (NCT02262377)
- Testing
- Integrative Medicine Group Visits
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Boston Medical Center
Idiopathic Scoliosis
The Role of Genetic Factors in the Development of Idiopathic Scoliosis in the Kazakh Population
The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms…
- Trial name
- NCT05095129
- Testing
- SNP analysis of the DNA
- Where
- Kazakhstan
- Volunteers
- 400 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Healthy Volunteer
Bioequivalence Study of Denosumab CP4 Drug Product and Commercially Available Denosumab CP2 Drug Product
To evaluate the bioequivalence based on pharmacokinetics (PK) of a single 120 mg subcutaneous dose of denosumab administered to healthy volunteers using denosumab CP4 or denosumab CP2 drug products.
- Trial name
- NCT02053753
- Testing
- Denosumab CP4, Denosumab CP2
- Where
- 2 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Amgen
Dyskinesia, Schizophrenia
Ethyl-Eicosapentaenoic Acid and Tardive Dyskinesia
Tardive dyskinesia is a common complication of conventional antipsychotic treatment in subjects with schizophrenia. This study investigates whether the addition of the omega-3 fatty acid, ethyl-eicosapentaenoic acid (EPA) to…
- Trial name
- NCT00114595
- Testing
- eicosapentaenoic acid
- Where
- South Africa
- Volunteers
- 84 people
- Sponsor
- University of Stellenbosch
Healthy
Relative Bioavailability of BMS-931699 From Prefilled Syringe Compared to Drug in Vial
A Phase 1, relative bioavailability study of BMS-931699 from prefilled syringe compared to drug in vial
- Trial name
- NCT03058822
- Testing
- BMS-931699
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Coronary Artery Disease
Vericiguat Drug-drug Interaction Study With Isosorbite Mononitrate in Stable Coronary Artery Disease Patients
This study is intended to investigate the pharmacodynamic drug-drug interaction as well as the safety and tolerability of isosorbite mononitrate and vericiguat in patients with stable coronary artery disease.
- Trial name
- VISOR (NCT03255512)
- Testing
- Vericiguat (BAY1021189), Isosorbide mononitrate (ISMN)
- Where
- 6 sites in Germany
- Volunteers
- 41 people
- Sponsor
- Bayer
Chronic Idiopathic Constipation
Lubiprostone for Treatment of Chronic Idiopathic Constipation
The purpose of this study was to evaluate the efficacy and safety of oral administration of lubiprostone 24 μg twice daily (BID) for 4 weeks in participants with chronic idiopathic constipation (CIC) compared with placebo.
- Trial name
- NCT02695719
- Testing
- Lubiprostone
- Where
- 5 sites in South Korea
- Volunteers
- 156 people
- Sponsor
- Takeda
Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria
Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in Thailand
This study assesses the effectiveness of reactive focal mass drug administration (rfMDA), targeting both village and forest working populations, compared to control for reducing the health promotion hospital-level (sub-district)…
- Trial name
- COMBAT (NCT05052502)
- Testing
- Case Management and Follow-up, Reactive focal mass drug administration (rfMDA)
- Where
- Thailand
- Volunteers
- 14,977 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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