Clinical trials: Population at Risk
Type 2 Diabetes Mellitus, Cardiovascular Disease
Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (Core and Extension Phases)
The purpose of this study was to determine whether, in patients with type 2 diabetes and pre-existing disease of the heart and the circulatory system and/or the kidney, aliskiren at a target dose of 300 mg once daily (compared to…
- Trial name
- ALTITUDE (NCT00549757)
- Testing
- Aliskiren
- Where
- 776 sites in United States, Argentina and 35 more
- Volunteers
- 8,606 people
- Sponsor
- Novartis Pharmaceuticals
Monkeypox
Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia
Background: Mpox is a zoonotic disease caused by the mpox virus (MPXV). It has been endemic in West and Central African countries.
- Trial name
- MPOX-COL (NCT06223919)
- Testing
- LC16m8
- Where
- 3 sites in Colombia
- Volunteers
- 8,686 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Cancer, Pediatrics
SPOG 2015 FN Definition. A Multi-center Non-inferiority Trial on Safety of a High Versus Low Temperature Limit Defining Fever in Pediatric Patients With Cancer at Risk for Fever in Chemotherapy-induced Neutropenia
In a multi-center open-label cluster-randomized controlled parallel-group multiple crossover non-inferiority trial in children and adolescents up to 20 years diagnosed with cancer requiring chemotherapy, primarily the safety, and…
- Conditions
- Cancer, Pediatrics, Fever, Neutropenia
- Trial name
- NCT02324231
- Testing
- 39.0°C temperature limit defining fever, 38.5°C temperature limit defining fever
- Where
- 6 sites in Switzerland
- Volunteers
- 269 people
- Sponsor
- Swiss Pediatric Oncology Group
Multiple Sclerosis
Prevalence of Fabry Disease in a Defined Population at Risk - Patients Formerly Diagnosed With Multiple Sclerosis
The association of Multiple Sclerosis (MS) and Fabry disease is known from own clinical experiences as well as from case reports in the literature, where symptoms and suspicious results in the brain MRI led to the misdiagnosis of…
- Trial name
- NCT01271699
- Volunteers
- 250 people
- Sponsor
- CENTOGENE GmbH Rostock
End-stage Renal Disease, SARS-CoV-2 Acute Respiratory Disease
SARS-COV-2 Screening in Dialysis Facilities
Patients receiving dialysis are one of the highest risk groups for serious illness with SARS-CoV-2 infection. In addition to the inherent risks of travel to and dialysis within indoor facilities, patients receiving dialysis are…
- Conditions
- End-stage Renal Disease, SARS-CoV-2 Acute Respiratory Disease, Dialysis; Complications
- Trial name
- NCT05225298
- Testing
- Offering SARS-CoV-2 test
- Where
- United States
- Volunteers
- 2,389 people
- Sponsor
- Stanford University
HIV/AIDS
Hybrid STTR Intervention for Heterosexuals: Anonymous Testing and Confidential Care Linkage
The Brooklyn Community United (BCU) study is a supplement to the main research study titled "Peer Driven Intervention to Seek, Test, \& Treat Heterosexuals at High Risk for HIV." The main study's field name is Brooklyn Community…
- Trial name
- BCU (NCT02421159)
- Testing
- Seek and Test Phase, Treat and Retain Phase
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- New York University
Cardiovascular Disease, Coronary Heart Disease, Dyslipidemia, Peripheral Arterial Disease (PAD)
A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease…
- Trial name
- NCT01516541
- Testing
- Background care, dalcetrapib
- Where
- 241 sites in United States, Australia and 11 more
- Volunteers
- 2,220 people
- Sponsor
- Hoffmann-La Roche
Hypertension, Mhealth
Effect of Digital Intervention on Self-management of Hypertensive Patients at High Risk of Stroke
Stroke is the second leading cause of death in the world, and the number of stroke patients in China ranks the first in the world. Hypertension is the most important risk factor.
- Trial name
- NCT07089810
- Testing
- Digital intervention has a high blood pressure in the high-risk population of stroke Study on the effect of stress on self-management behavior of patients
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Nantong University
Pre-diabetes
Motivational Instant Messaging and E-diabetes Prevention Programme for High Risk of Type 2 Diabetes
The overall aim of this feasibility trial is to assess the effectiveness of a wearable technology and an e-diabetes prevention programme delivered via a smartphone application, including motivational messaging, in reducing weight…
- Trial name
- NCT02919397
- Testing
- Wearable technology, Diabetes Prevention Programme educational material, Motivational messaging
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King's College London
Ankle Fracture
Ankle Fracture Treatment in the Elderly
The purpose of this study is to track surgical outcomes and post-operative course in patients 55 years of age or older treated for ankle fractures.
- Trial name
- NCT01444144
- Testing
- Fracture union
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Florida
Liver Cirrhosis, Liver Fibrosis
Sonazoid CEUS for Early HCC Surveillance
This study is a multicenter, prospective study. In this study, enrolled subjects are cirrhotic patients of any etiology. The US and Sonazoid CEUS monitoring strategy was performed for cirrhotic patients: US and AFP joint with…
- Trial name
- NCT07590284
- Testing
- Sonazoid CEUS
- Where
- China
- Volunteers
- 556 people
- Sponsor
- Tianjin Third Central Hospital
Type 1 Diabetes
Screening Program for Type 1 Diabetes in a High-Risk Population
Type 1 diabetes mellitus (T1D) is a growing public health concern in Saudi Arabia, ranking ninth globally in T1D incidence and tenth in T1D prevalence in children, and the rates are expected to rise and incur greater healthcare…
- Trial name
- NCT06513247
- Testing
- screening for Islet autoantibody, HLA phenotype and genetic risk score
- Where
- Saudi Arabia
- Volunteers
- 1,300 people
- Sponsor
- King Saud University
Directly Observed Therapy, HIV Infections
Directly Observed Therapy in High Risk Populations in Newark, NJ
30 patients with poor antiretroviral therapy compliance will be identified from our pool of patients at Saint Michael's Medical Center and be given Directly observed therapy.
- Trial name
- NCT00285883
- Testing
- Invirase, Norvir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Michael's Medical Center
Rheumatoid Arthritis
Standard Versus High Dose Inactivated Influenza Vaccine in RA
Patients with rheumatoid arthritis have increased risk of seasonal influenza and influenza-related complications but have reduced vaccine immunogenicity.
- Trial name
- IV-RA (NCT02936180)
- Testing
- HD-TIV, SD-QIV
- Where
- Canada
- Volunteers
- 279 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Platelet Dysfunction Due to Aspirin
Genotypic and Phenotypic Correlates of Resistance to Aspirin
The study seeks to identify genomic markers associated with aspirin resistance.
- Trial name
- ARSENAL (NCT01361620)
- Testing
- aspirin
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- George Washington University
Sleep Apnea
Evaluation of New Diagnostic and Treatment Algorithm for Obstructive Sleep Apnea
Newer home sleep study device and algorithm provides an alternative for inpatient sleep study and improve the service provides to patients
- Trial name
- NCT00425659
- Testing
- home sleep study, home CPAP titration (Autoset), CPAP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Acute Respiratory Distress Syndrome, Coronavirus
Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).
This is a multicenter, randomized, double-blind, parallel group study to investigate the efficacy of pemziviptadil (PB1046) by improving the clinical outcomes in hospitalized COVID-19 patients at high risk for rapid clinical…
- Conditions
- Acute Respiratory Distress Syndrome, Coronavirus, Hypoxic Respiratory Failure, Hypoxemic Respiratory Failure
- Trial name
- VANGARD (NCT04433546)
- Testing
- Pemziviptadil (PB1046), Low Dose (10 mg) Control
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- PhaseBio Pharmaceuticals Inc.
Pregnancy, Pregnancy Complications
Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be
Forty percent of pregnant women in the United States are women who have never given birth. As a group, they sometimes have complications with their pregnancy, but there is no information from a previous pregnancy to identify who…
- Trial name
- nuMoM2b (NCT01322529)
- Where
- 17 sites in United States
- Volunteers
- 10,038 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Alzheimers Disease
A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
The purpose of this study is to determine the effects of CNP520 on cognition, global clinical status, and underlying AD pathology, as well as the safety of CNP520, in people at risk for the onset of clinical symptoms of AD based…
- Trial name
- GS2 (NCT03131453)
- Testing
- CNP520 50mg, CNP520 15mg
- Where
- 194 sites in United States, Argentina and 23 more
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Chronic Pain, Opioid Misuse
Integrative Psychosocial Group Treatment
A fundamental challenge for healthcare is to achieve a balance between decreasing the misuse of opioids and associated harms while optimizing patient care, including the provision of multidisciplinary treatments for chronic pain.
- Trial name
- NCT03648177
- Testing
- IPGT, Treatment as Usual
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh