Clinical trials: Population at Risk
Cerebrovascular Accident, Stroke
Screening and Management of High-risk Populations of Stroke in Dehui City
This epidemiological survey is to analyze the prevalence rate of stroke and exposure rate of risk factors in sampling population aged 40 years and over (born before December 31,1975) in Dehui City, to provide scientific basis for…
- Conditions
- Cerebrovascular Accident, Stroke, Hypertension, Diabetes Mellitus
- Trial name
- SAMHPSDC (NCT05039034)
- Testing
- Advice according to primary prevention guidelines on stroke of China
- Where
- China
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- Yi Yang
Frail Elderly, Aging
Targeting Aging With a Ketone Ester for Function in Frailty
This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight…
- Conditions
- Frail Elderly, Aging, Immune Function, Muscle Function
- Trial name
- TAKEOFF (NCT06645847)
- Testing
- Ketone ester
- Where
- 3 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Buck Institute for Research on Aging
Mood Disorders, Prodromal Symptoms
MBCT and CBT for Youth at High Risk for Mood and Psychotic Disorders: a Randomized Controlled Trial
The present study is a randomized controlled trial comparing the efficacy and acceptability of CBT and MBCT group-based interventions adapted for young people at elevated risk for mood or psychotic disorder onset or relapse.
- Conditions
- Mood Disorders, Prodromal Symptoms, Bipolar Disorder, Parents
- Trial name
- NCT05070052
- Testing
- cognitive behavioral therapy, mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Los Angeles
ATTR-CM (Transthyretin Amyloid Cardiomyopathy), Heart Failure
Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis
People eligible for this study have had the suggestion from their doctor to receive a cardiac pacemaker or defibrillator to treat a cardiac condition as part of their routine care.
- Trial name
- RV-CAM (NCT07784712)
- Volunteers
- 70 people
- Sponsor
- Geisinger Clinic
Asymptomatic Amyloid-positive
An Efficacy and Safety Study of Atabecestat in Participants Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia
The purpose of this study is to evaluate whether treatment with atabecestat slows cognitive decline compared with placebo treatment, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive Composite…
- Trial name
- EARLY (NCT02569398)
- Testing
- Atabecestat, 5 mg, Atabecestat, 25 mg
- Where
- 128 sites in United States, Australia and 11 more
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Dementia
Assessing Dementia Risk in the Community: The Dementia Population Risk Tool
The purpose of this study is to develop and validate the Dementia Population Risk Tool (DemPoRT) algorithm to predict dementia incidence in the population setting.
- Trial name
- DemPoRT (NCT03155815)
- Volunteers
- 75,460 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Post Intensive Care Syndrome, Anxiety
Targeted Group-based Psychotherapy to Address Emotional Stress in at Risk ICU Survivors
This study is a pilot clinical trial to assess the feasibility of implementing a group-psychotherapy intervention to modify emotional stress (e.g., anxiety, depression, post-traumatic stress) following ICU hospitalization
- Conditions
- Post Intensive Care Syndrome, Anxiety, Traumatic Stress, Depression
- Trial name
- NCT05856240
- Testing
- Managing Stress & Emotions Group (MSEG)
- Sponsor
- Beth Israel Deaconess Medical Center
Plaque, Atherosclerotic Disease
BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population
The BioImage Study is a study of the characteristics of subclinical cardiovascular disease, as measured by imaging modalities, unsupervised circulating biomarker measurements, and risk factors that predict progression to overt…
- Conditions
- Plaque, Atherosclerotic Disease, Heart Disease, Stroke
- Trial name
- NCT00738725
- Where
- 2 sites in United States
- Volunteers
- 7,687 people, healthy volunteers welcome
- Sponsor
- BG Medicine, Inc
Depression, Anxiety
CES and EGChatbot in Reducing Anxiety, Depression, Insomnia, and Mental Risk
The objective of this three-year study is to provide comprehensive care to young adults presenting with ARMS. The aim is use an exercise group (EGChat) developed by prior study and CES to decrease cognitive mental risks, improve…
- Trial name
- NCT06493695
- Testing
- Both EGChat and CES intervention, Exercise Chatbot, CES (Cranial Electrotherapy Stimulation)
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- China Medical University Hospital
Chronic Pain in the Extremities, Chronic Abdominal Pain
Screening for Fabry Disease in a Pediatric Population at Risk
The purpose of this study is to assess the frequency of Fabry disease in children with chronic abdominal pain or chronic pain in the extremities
- Conditions
- Chronic Pain in the Extremities, Chronic Abdominal Pain, Fabry Disease
- Trial name
- NCT02152189
- Testing
- Screening for Fabry disease
- Where
- Germany
- Volunteers
- 1,422 people
- Sponsor
- University Hospital Heidelberg
Pulmonary Artery Hypertension
Vascular Subphenotypes of Lung Disease in HIV & COPD
This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.
- Trial name
- VAST (NCT01581086)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Accidental Falls
Advances in Group-based Falls Rehabilitation
This study's main aim is to compare the effect of a modified FaME vs. a multisensory balance exercise programme on falls risk, balance confidence and quality of life in older adults who fall or at risk of falling when implemented…
- Trial name
- NCT02696668
- Testing
- modified FaME, Multisensory
- Volunteers
- 100 people
- Sponsor
- King's College London
Obstructive Sleep Apnea of Child
Cytokine Persistence as a Marker of Inflammation in the at Risk, Low Socioeconomic Status Pediatric Population
The investigators wish to study the role of persistent markers of inflammation in executive function in young children during critical periods of synaptogenesis (ages 2-3).
- Trial name
- NCT03134300
- Testing
- Cytokine from blood
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Osteoporosis, Fracture
Osteoporosis and Fall Prevention High Risk Population Intervention and Follow up in the Metropolitan Area
BACKGROUND: The deterioration of musculoskeletal system imposes significant impact on physical activity in older adults. METHODS: This was a randomized, parallel-group, prospective study.
- Trial name
- NCT02608749
- Testing
- Integrated care (IC), Lower extremity exercise (LEE), Home care (HC)
- Where
- Taiwan
- Volunteers
- 151 people
- Sponsor
- National Taiwan University Hospital
Lung Cancer, Lung Neoplasms
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening.
- Conditions
- Lung Cancer, Lung Neoplasms, Early Lung Cancer Detection, Cancer Screening
- Trial name
- NCT07358715
- Testing
- Liquid Biopsy (SPOT-MAS Assay), Exosome-Based Liquid Biopsy Assay, Low-Dose CT Thorax (LDCT)
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Adrenal Gland Hypofunction
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. Identification of patients at risk would be of high clinical importance.
- Trial name
- NCT00975078
- Testing
- adrenal insufficiency testing, prednisone
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Gastric Ulcer
Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen
This study uses a randomized, double-blind, controlled design to demonstrate that PN400 (esomeprazole and naproxen) is more effective in reducing the occurrence of gastroduodenal ulcers, dyspepsia, and heartburn in subjects at…
- Trial name
- NCT00527787
- Testing
- PN400 (VIMOVO), Naproxen
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- POZEN
Prediction of High-risk Populations for Sarcopenia
Evaluation of a Sarcopenia Prediction Model and Development and Effectiveness of a Nursing Guidance Mobile App
We evaluated a model for the prediction of high-risk populations for sarcopenia in home settings, developed a sarcopenia nursing guidance mobile application, and assessed the effectiveness of this application in influencing…
- Trial name
- NCT05363033
- Testing
- sarcopenia nursing guidance mobile application was developed
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Heart Failure, Chronic Kidney Diseases
Screen CardRen - A Cross-sectional Observational Cohort Study
In this single-centre, cross-sectional study, the investigators aim to assess the prevalence of asymptomatic echocardiographic structural and functional cardiac abnormalities in adult CKD patients with additional cardiovascular…
- Trial name
- NCT06272578
- Testing
- Echocardiography
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Charite University, Berlin, Germany
Colorectal Cancer, Colorectal Neoplasms
Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma
This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma
- Trial name
- reconAAsense (NCT05636085)
- Testing
- Mainz Biomed Colorectal Cancer Screening Test
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed