Clinical trials: Population at Risk
Stigma, Social, Help-Seeking Behavior
Digital Mental Health Care for COVID-19 High-Risk Populations - Phase 2
The mental health consequences of the COVID-19 (Coronavirus Disease of 2019) pandemic are likely to be vast, exceeding the capacity of mental health services and delaying treatment for people in need, with devastating…
- Trial name
- NCT05826132
- Testing
- Adjusted Content Intervention, Non-Adjusted Intervention Video
- Where
- United States
- Volunteers
- 1,402 people, healthy volunteers welcome
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Chronic Hepatitis C, Intravenous Drug Usage
Enhancing Access to Care for Chronic Hepatitis C Infected Populations in Hong Kong
In the current era of highly effective direct acting antiviral (DAA) therapy, the remaining obstacles to elimination of chronic HCV infection are identification of the high-risk groups, linkage to continued care and prevention of…
- Trial name
- NCT03993925
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- The University of Hong Kong
Placenta Accreta
Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population
Abnormally invasive placenta (AIP) is defined as an abnormal placental attachment of a part or the entire chorionic plate with penetration of chorionic villi in the myometrium and absence of the decidua basalis.
- Trial name
- NCT02302573
- Testing
- contast-enhanced ultrasound with sonovue
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Calciphylaxis
Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome
Calciphylaxis, also called Calcific Uremic Arteriolopathy (CUA) is a lethal affection mostly affecting patient in end stage renal disease. The survival rate is described around 20 to 46% at one year.
- Trial name
- CalciWest (NCT02854046)
- Testing
- Calcific Uremic Arteriolopathy
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Liver Diseases, Alcoholic, Fibrosis
Screening At-risk Populations for Hepatic Fibrosis With Non-invasive Markers
Prospective screening study at Odense University Hospital to assess the effect of transient elastography and other serum and imaging markers of liver fibrosis to detect advanced fibrosis (Kleiner Fibrosis score F3-F4) in patients…
- Trial name
- SIPHON (NCT03308916)
- Testing
- transient elastography, Enhanced liver fibrosis test, Indirect serum markers of liver fibrosis
- Where
- Denmark
- Volunteers
- 6,500 people
- Sponsor
- Maja Thiele
Glaucoma
Glaucoma Screening to Enhance At-Risk Californians' Health
The vast majority of glaucoma cases in the United States go undetected and untreated until the late stages of the disease. Open-angle glaucoma is a progressive condition that is asymptomatic in its early to moderate stages and…
- Trial name
- G-SEARCH (NCT06854198)
- Testing
- Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry, Educational Brochure
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression, Depressive Disorder, Major
Mothers With a History of Depression and Their 10-14 Year Old Daughters
The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally.
- Trial name
- NCT01129752
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Stanford University
Ovarian Cancer, Breast Cancer
Lynne Cohen Consortium Project: Multi-Center Database/Registry
Goals of this registry: 1.1 To collect and store very limited demographic information (age, birthdate, race and ethnicity), limited cancer risk and breast and ovarian disease history, as well as limited family history of breast…
- Trial name
- NCT00776958
- Testing
- Questionnaire
- Where
- 4 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pelvic Floor Disorders, Pelvic Floor; Incompetency
Postpartum Pelvic Floor Workshop
After having a baby, there are some expected changes in pelvic floor function. However, tearing of the pelvic floor, having a large baby and needing a vacuum or forceps to deliver the baby put women at risk for having pelvic…
- Conditions
- Pelvic Floor Disorders, Pelvic Floor; Incompetency, Pelvic Floor Muscle Weakness, Perineum; Injury
- Trial name
- PPFW (NCT04754984)
- Testing
- Pelvic floor workshop
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Respiratory Distress Syndrome in Premature Infant
A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact
The purpose of this two-part Phase 2 study is to assess the safety, tolerability and efficacy of aerosolized SF-RI 1 (AeroFact) when delivered via nCPAP at two different doses.
- Trial name
- NCT03969992
- Testing
- AeroFact, nCPAP
- Where
- 41 sites in United States, Canada
- Volunteers
- 261 people
- Sponsor
- Aerogen Pharma Limited
Diabetes Mellitus
Preventing Renal Functional Abnormalities With Calorie Restriction in Subjects With Abdominal Obesity and Type 2 Diabetes at Increased Renal and Cardiovascular Risk
The study investigates whether a caloric restricted dietary regime can prevent onset and/or progression of chronic kidney disease in type 2 diabetic patients with abdominal obesity, through the amelioration of concomitant…
- Trial name
- CRESO (NCT01213212)
- Testing
- Caloric restriction, No intervention
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Ultrasonography, Breast Neoplasm Female
Intelligent Remote Intervention for High-risk Breast Cancer Populations
The goal of this clinical trial is to compare the effects of modern remote health intervention regime with traditional in-person intervention strategies for high-risk breast cancer groups that with BI-RADS 3 or higher nodules.
- Conditions
- Ultrasonography, Breast Neoplasm Female, Breast Carcinoma, Health Education
- Trial name
- NCT06193707
- Testing
- the Remote Intervention, the Traditional Intervention
- Volunteers
- 1,250 people
- Sponsor
- Qianfoshan Hospital
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on the Development of Allergic Manifestations in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- MAESTRO (NCT03062995)
- Testing
- Infant Formula with added synbiotics, Standard Infant formula
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nutricia Research
Fetal Growth Retardation
Prediction of Placental Fetal Growth Restriction in High Risk Population (PoPFGR)
This study intends to prospectively enroll high-risk pregnant women to establish a multicenter cohort. By combining maternal basic characteristics, medical history, early pregnancy ultrasound, and biological markers, we aim to…
- Trial name
- NCT06096805
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Alcoholic Liver Disease (ALD), Alcohol Use Disorder
Elastography-based Brief Alcohol Intervention in Hospitalized Individuals
Harmful alcohol use is a common cause of hospital admissions and the leading cause of liver cirrhosis. Timely detection of liver disease is crucial to prevent liver disease progression and reduce alcohol-related harms.
- Trial name
- PREDILECTION (NCT07637539)
- Testing
- Elastography-based brief alcohol intervention
- Where
- 8 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Morbidly Adherent Placenta, Placenta Accreta
Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta
The purpose of this study is to determine whether, in a high risk population (placenta praevia and previous caesarean or prenatal suspicion of morbidly adherent placenta (MAP)), the concentration of cell-free fetal DNA…
- Conditions
- Morbidly Adherent Placenta, Placenta Accreta, Placenta Increta, Placenta Percreta
- Trial name
- DNA-Accreta (NCT02784886)
- Testing
- Women at high risk of MAP
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Angers
Transgenderism
Evaluation of an Adaptative, Multidisciplinary, Reach-out Program, Facilitating Pre Exposition HIV Prophylaxis (PrEP) Prescription and Retention in Care, in a Group of Trans Womens (TW) at High Risk of HIV Infection.
Evaluation of an adaptative, multidisciplinary, reach-out program, facilitating pre exposition HIV prophylaxis (PrEP) prescription and retention in care, in a group of trans womens (TW) at high risk of HIV infection.
- Trial name
- PrEP à porter (NCT05415930)
- Testing
- Psychosocial assistance, Medical care, Legal-Administrative Assistance
- Volunteers
- 100 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Colorectal Cancer, Genetics of
Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population
The purpose of this study is to determine if the adherence to screening in first grade relatives of patients with CCR is higher than optical colonoscopy.
- Trial name
- CRIBADO (NCT01557101)
- Testing
- COLON CAPSULE ENDOSCOPY ADHERENCE, OPTICAL COLONOSCOPY ADHERENCE
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Canarias
Breast Cancer, Neutropenia
Safety and Efficacy Study of GCSF Therapy to Treat Patients at High Risk for Chemotherapy Induced Severe Neutropenia
The overall purpose of this study is to assess the dose response, efficacy, and safety of three different dose levels of AVI 014 (granulocyte colony-stimulating factor [G-CSF]) in breast cancer patients at high (>20%) risk for…
- Trial name
- NCT00497809
- Testing
- AVI-014 versus Filgrastim
- Where
- 31 sites in United States, India
- Volunteers
- 189 people
- Sponsor
- AviGenics
Uncontrolled Hypertension, Cardiovascular Risk Factor
Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease
The largest epidemiologic study of Hispanic/Latino participants thus far, i.e., the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) documented that 80% of men and 71% of women have at least one major cardiovascular…
- Trial name
- NCT03221114
- Testing
- Positive Psychological Intervention
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Illinois at Urbana-Champaign