Clinical trials: Population at Risk
Urinary Tract Infections, Complicated Urinary Tract Infection
Evaluating UTI Outcomes in at Risk Populations
This is a multicenter, observational comparative cohort, study to evaluate the UTI related adverse event rates between Guidance® UTI clinical pathway versus the current traditional clinical pathways for urine testing.
- Trial name
- At Risk (NCT05385536)
- Where
- United States
- Volunteers
- 7,921 people
- Sponsor
- Pathnostics
At-risk Mental States
Prospective Cohort Study of a Population at Risk of Psychotic Transition
In psychiatry, insight is the patient's awareness of his or her disorder or symptom. Lack of insight also seems to be associated with the presence of anxiety-depressive symptoms.
- Trial name
- EPEDIP (NCT06539611)
- Testing
- Observational
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Centre Hospitalier Esquirol
Chronic Kidney Diseases, Heart Failure
REducing Sympathetic Activity Through Ultrasound-based Renal deneRvation in Excessive Cardiovascular Risk populaTions.
The is a non-randomized pilot trial, open-label evaluation of the physiologic response of native kidney denervation using the Paradise denervation system in CKD, End Stage Renal Disease (ESRD), and Heart failure (HF)
- Conditions
- Chronic Kidney Diseases, Heart Failure, End Stage Renal Disease
- Trial name
- RESURRECT (NCT05703620)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 75 people
- Sponsor
- Royal Perth Hospital
Cardiovascular Diseases, Hypercholesterolemia
Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol)
Potential cholesterol-lowering effect of a regular intake of a plant sterol (PS)-containing food supplement, in overweight/obese type 1 or 2, normoglycemic/pre-diabetic, with LDL-cholesterol values > 115 mg/dl and not…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Prediabetic State, Overweight and Obesity
- Trial name
- NCT06481020
- Testing
- Plant sterols 2g/day
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Valencia
Chronic Obstructive Pulmonary Disease
Prevalence Study and Regular Practice Among General Practitioners in Populations at Risk of Chronic Obstructive Pulmonary Disease (COPD) in Latin America
PUMA is an observational, multicentre, multinational, cross-sectional study with primary care physicians (primary care, general and family physicians).
- Trial name
- PUMA PROJECT (NCT01493544)
- Where
- 18 sites in Argentina, Colombia and 2 more
- Volunteers
- 1,907 people
- Sponsor
- AstraZeneca
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- TEMPO (NCT03067714)
- Testing
- Infant formula with added synbiotics, Standard infant formula
- Where
- 59 sites in Belgium, Czechia and 11 more
- Volunteers
- 855 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Asthma Control
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe.
- Trial name
- HOTHOT (NCT07309614)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 150 people
- Sponsor
- Université de Sherbrooke
Obstructive Sleep Apnea (OSA)
Point of Care Ultrasound in Pregnant Women (PoCUS-OB)
Pregnant women with gestational age more than 20 weeks are at risk of developing Obstructive Sleep Apnea (OSA). OSA is a common underdiagnosed comorbid condition in pregnant women associated with adverse maternal and fetal…
- Trial name
- NCT06776237
- Testing
- PoCUS
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Type 2
A Trial on Ophthalmologist-delivered Health Education on Top of Routine Community Care
Diabetic retinopathy affects over one third of all people with diabetes and is one of the leading causes of vision loss. The management of diabetes and its complications should include screening for diabetic retinopathy.
- Trial name
- NCT04490941
- Testing
- Ophthalmologist-delivered health education, Usual care
- Where
- China
- Volunteers
- 652 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Social Determinants of Health, Major Depressive Disorder
The Role of Social Determinants in Cardiovascular Health and Vascular Function
This study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities.
- Conditions
- Social Determinants of Health, Major Depressive Disorder, Cardiovascular Diseases
- Trial name
- CVRRC (NCT05772221)
- Testing
- Screening
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Postmenopausal Osteoporosis
Efficacy and Safety of QL1206 in the Treatment of Postmenopausal Osteoporosis With High Fracture Risk
A randomized, double-blind, two-group parallel, placebo-controlled clinical Phase III trial to compare the efficacy and safety of QL1206 and placebo in postmenopausal women with osteoporosis at high risk of fracture
- Trial name
- NCT04128163
- Testing
- QL1206
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Moral Injury, TEPT
A Comprehensive Group Intervention for Psychosocial Personnel at Risk of Stress and Moral Injury
The objective of this randomized controlled trial is to evaluate the effectiveness of the CARE-MI group intervention in reducing symptoms of post-traumatic stress and moral injury in support staff working with individuals…
- Trial name
- CARE-MI-PsychS (NCT07140263)
- Testing
- CARE MI, TAU: Treatment as usual
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Leukoaraiosis
the Effects of Cerebral Collateral Circulation on the Outcome of Leukoaraiosis in High-risk Population
This study observed the relationship between cerebral collateral circulation and the prognosis of leukoaraiosis in high-risk population.
- Trial name
- NCT03246373
- Where
- China
- Volunteers
- 1,037 people
- Sponsor
- Shanghai Zhongshan Hospital
Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population
Advancing Early Bone Health: New Frontiers for Osteoporosis Prevention
All factors that influence the peak bone mass achieved at skeletal maturity are important in determining an individual's risk of developing osteoporosis later in life.
- Conditions
- Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population, Healthy Neonatal Population
- Trial name
- REMS-BONE (NCT06750523)
- Testing
- Cord blood sampling, urine sampling, Life style questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Parma
Primary Prevention of Cardiovascular Disease
Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations
The goal of this clinical trial is to determine whether incorporating a polygenic risk score (PRS) can optimize primary cardiovascular disease prevention in individuals with intermediate cardiovascular risk.
- Trial name
- PERSONAL (NCT07039123)
- Testing
- Polygenic Risk Score for Coronary Artery Disease (PRS-CAD), Standardized Risk Communication Tool (SCORE2)
- Where
- 2 sites in Switzerland
- Volunteers
- 205 people
- Sponsor
- University of Bern
Morbidly Adherent Placenta, Placenta Accreta
Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta
The purpose of this study is to determine whether, in a high risk population (placenta praevia and previous caesarean or prenatal suspicion of morbidly adherent placenta (MAP)), the concentration of cell-free fetal DNA…
- Conditions
- Morbidly Adherent Placenta, Placenta Accreta, Placenta Increta, Placenta Percreta
- Trial name
- DNA-Accreta (NCT02784886)
- Testing
- Women at high risk of MAP
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Angers
Glaucoma
Comparison Study of Glaucoma Eye Care Follow-Up Adherence in a High Risk Population
The project aims to determine the effectiveness of a patient-centered health care delivery system focused on improving follow-up adherence in patients diagnosed with glaucoma.
- Trial name
- NCT02347670
- Testing
- Efficacy-patient navigator to improve follow-up adherence, Office-Based Usual Care
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Wills Eye
Sleep Apnea
Evaluation of New Diagnostic and Treatment Algorithm for Obstructive Sleep Apnea
Newer home sleep study device and algorithm provides an alternative for inpatient sleep study and improve the service provides to patients
- Trial name
- NCT00425659
- Testing
- home sleep study, home CPAP titration (Autoset), CPAP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Trisomy 21, 18 and 13 Screening
T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients
The purpose of this study is to evaluate the performance of non invasive screening in a population of pregnant women with and without in vitro fertilisation (IVF) concomitantly to regular first trimester trisomy 21 (T21)…
- Trial name
- DEPOSA (NCT02424474)
- Testing
- Genetic NIPT, Regular serum screening
- Where
- France
- Volunteers
- 933 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infection
A Pilot Study of Pre-Exposure Prophylaxis (PrEP) to Evaluate Safety, Acceptability, and Adherence in At-risk Populations in Uganda, Africa
This study will evaluate the safety and acceptability of intermittent and daily pre-exposure prophylaxis (PrEP) regimens with FTC/TDF (emtricitabine/tenofovir disoproxil fumarate) in HIV discordant couples, and it will directly…
- Trial name
- NCT00931346
- Testing
- FTC/TDF
- Where
- Uganda
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative