Clinical trials: Port-Wine Stain
Port-wine Stain
A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain
This pilot study aims to evaluate the efficacy and safety of hemoporfin photodynamic therapy (PDT) with different light doses for port-wine stain (PWS） in 7-14 years old children.
- Trial name
- NCT03125057
- Testing
- Hemoporfin PDT
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Port-Wine Stain
Tolerability of 532 nm Laser Treatment of Port Wine Stains
The goal of this study is to learn about treatment of port wine birthmarks treated with an FDA-approved 532 nm laser. The main questions it aims to answer are: How well are the treatments tolerated? Are there differences in…
- Trial name
- NCT05841628
- Testing
- 532 nm laser treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Port Wine Stain, Klippel Trenaunay Syndrome
French National Cohort of Children With Port Wine Stain
Port Wine Stain on a limb can be either isolated or associated with complications (venous or orthopedic impairment, arteriovenous malformations), leading sometimes to complex syndromes (Klippel-Trenaunay syndrome,Parkes-Weber…
- Conditions
- Port Wine Stain, Klippel Trenaunay Syndrome, Parkes Weber Syndrome
- Trial name
- CONAPE (NCT01364857)
- Testing
- search for polymorphisms of RASA1 gene
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
PORT WINE STAIN
Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field Functional Imaging Technologies
The researcher develop non-invasive imaging modalities for assessment of port wine stain during laser therapy treatment of Port Wine Stain.
- Trial name
- NCT01333553
- Testing
- Image-guided remove Port Wine Stain
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of California, Irvine
Port-wine Stain
Evaluate the Port-wine Stain Birthmark Treatment Before and After Pulsed Dye Laser Treatment
Port-wine stain is a congenital, progressive vascular malformation of human skin involving post-capillary venules that occurs in an estimated 0.3% of children and can alter personality development and psychological in children.
- Trial name
- NCT01774552
- Testing
- Photo Acoustic Microscopy and Optical Coherence tomography
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Port Wine Stain
Pilot Study on the Use of the Matrix Radiofrequencyfor Treatment of Port Wine Stain Birthmarks
Port wine stain, also called nevus flammeus, is a congenital, cutaneous vascular malformation involving post-capillary venules which produces a light pink to red to dark-red-violet discoloration of the skin.
- Trial name
- NCT01166919
- Testing
- Matrix Radiofrequency
- Sponsor
- University of California, Irvine
Von Hippel-Lindau Syndrome, Renal Cell Carcinoma
Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow
The goal of this clinical research study is to learn if sunitinib malate (SU011248) can help to control VHL. The safety of this drug will also be studied.
- Conditions
- Von Hippel-Lindau Syndrome, Renal Cell Carcinoma, Hemangioblastoma
- Trial name
- NCT00330564
- Testing
- SU011248
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy Subjects
A Comparative Study of the Pharmacokinetic Profiles of Timolol Maleate Ophthalmic Gel With Timolol Maleate Gel
The goal of this clinical trial is: 1)To evaluate the pharmacokinetic profiles and safety of 0.5% Timolol Maleate Ophthalmic Gel Forming Solution in healthy adult subjects after multiple dosing; 2)To compare the systemic exposure…
- Trial name
- NCT06813807
- Testing
- 0.5% TM
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Auson Pharmaceuticals Inc.
Infantile Hemangioma
Nadolol Versus Propranolol in Children With Infantile Hemangiomas
The purpose of this study is to assess the efficacy and safety of oral propranolol versus nadolol in patients with Infantile Hemangiomas (IH) in a randomized, controlled, double-blinded study.
- Trial name
- NCT02505971
- Testing
- Nadolol, Propranolol
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- The Hospital for Sick Children
Comparison of Efficacy of Sclerotherapy in Infantile Hemangioma
Efficacy of Intralesional Bleomycin Alone and in Combination With Dexamethasone in Infantile Haemangiomas
Objective: This study is intended to compare the outcome of intralesional bleomycin with dexamethasone versus the bleomycin alone in infantile haemangioma.
- Trial name
- hemangioma (NCT06080724)
- Testing
- Comparison of intralesional injection of bleomycin alone and combined with injection dexamethasone
- Where
- Pakistan
- Volunteers
- 114 people
- Sponsor
- King Edward Medical University
Infantile Hemangioma (IH)
Low-Dose Propranolol and Bleomycin for Infantile Hemangioma (IH)
This is a prospective, randomized controlled trial designed to evaluate the efficacy and safety of low-dose oral propranolol (1 mg/kg/day) combined with monthly intralesional bleomycin injections versus low-dose propranolol…
- Trial name
- NCT07104526
- Testing
- Propranolol + Bleomycin, Propranolol
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Wuhan Integrated Traditional Chinese and Western Medicine Hospital
Port-Wine Stain
Effect of Pulsed Dye Laser on Photodynamic Therapy of Port-Wine Stains
Port-wine stain (PWS) is a congenital capillary malformation with an incidence of 3-5/1000 newborns and grows commensurately with the affected individual.
- Trial name
- NCT04536740
- Testing
- PDT treatment device
- Volunteers
- 68 people
- Sponsor
- Gang Ma
Infantile Hemangioma
Optimizing Timolol Maleate Treatment of Infantile Hemangioma by Doppler Ultrasound Examination
The purpose of this study is to assess the safety and efficacy of Timolol Maleate treatment for different depth of infantile hemangioma based on B-ultrasonography.
- Trial name
- NCT03842631
- Testing
- Timolol Maleate 0.5% Oph Soln
- Where
- China
- Volunteers
- 150 people
- Sponsor
- XiaoXi Lin
Hemangioblastomas, Von Hippel Lindau Disease
Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblastoma From Von-Hippel-Lindau Disease
Von Hippel-Lindau (VHL) disease is an inherited syndrome manifested by a variety of benign and malignant tumors. Hemangioblastomas are the most common lesion associated with VHL disease affecting 60-84% of patients with a mean…
- Trial name
- NCT01015300
- Testing
- Avastin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Port Wine Stain
A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.
The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rapamycin will improve PWS…
- Trial name
- NCT00800722
- Testing
- Rapamycin Treatment of Port Wine Stain
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, Irvine
Port-wine Stains
Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study
Pulsed dye laser (PDL) is the gold standard treatment for port-wine stains (PWS). However, the outcomes are highly variable due to the new angiogenesis occurring after laser irradiation.
- Trial name
- NCT02317679
- Testing
- Bosentan, Pulsed dye laser (PDL)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Von Hippel-Lindau Syndrome
TKI 258 in Von Hippel-Lindau Syndrome (VHL)
The goal of this clinical research study is to learn if dovitinib can safely be given to patients who have VHL with a measurable hemangioblastoma (tumor of the central nervous system).
- Trial name
- NCT01266070
- Testing
- Dovitinib
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Hemangiomas of Infancy
Hemangioma Growth During the First 6 Months of Life
One of the most important and unique characteristics of infantile hemangiomas is their dramatic growth during early infancy. Most hemangiomas are either absent at birth or barely evident as a small scratch or bruise-like area.
- Trial name
- NCT00911781
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Port Wine Stain, Nevus of Ota
Optical Clearing of the Skin in Conjunction With Laser Treatments
The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light…
- Conditions
- Port Wine Stain, Nevus of Ota, Tattoos, Scars
- Trial name
- NCT00580736
- Testing
- Optical Clearing
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Irvine