Clinical trials: Portal Hypertension, open to volunteers
Cirrhoses, Liver
Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis.
- Trial name
- NCT07267260
- Testing
- Vonoprazan 20 mg
- Where
- Pakistan
- Volunteers
- 154 people
- Sponsor
- King Edward Medical University
Portal Hypertension Related to Cirrhosis, Ascites Hepatic
Effectiveness and Safety of TIPS Stent Graft in the Treatment of Cirrhosis and Complications of Portal Hypertension
This Study is a prospective, multi-center, single-arm objective perform an criteria (OPC) study. A 12 months follow-up study on the patients who intend to receive the treatment of cirrhosis and complications of portal…
- Conditions
- Portal Hypertension Related to Cirrhosis, Ascites Hepatic, Variceal Bleeding
- Trial name
- NCT06669806
- Testing
- TIPS Stent Graft
- Where
- China
- Volunteers
- 166 people
- Sponsor
- C. R. Bard
Liver Cirrhoses, Hepatocellular Carcinoma (HCC)
A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis
DETECT-HCC-ESLD is a prospective multicenter study designed to examine early detection and risk stratification of hepatocellular carcinoma (HCC) in individuals with advanced liver disease.
- Conditions
- Liver Cirrhoses, Hepatocellular Carcinoma (HCC), Sarcopenia in Liver Cirrhosis, Portal Hypertension Related to Cirrhosis
- Trial name
- DETECT-HCC (NCT07291141)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Mattias Ekstedt
BCAA, Cirrhosis
TIPS With or Without BCAA
Cirrhosis is a major global cause of morbidity and mortality in chronic liver disease patients, accounting for 2.4% of global deaths in 2019.
- Conditions
- BCAA, Cirrhosis, Portal Hypertension Related to Cirrhosis, Sarcopenia
- Trial name
- NCT07281846
- Testing
- The BCAA Group (experimental group) takes oral branched-chain amino acid (BCAA) supplements for 3 months starting after TIPS.
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Portal Hypertension Related to Cirrhosis, Esophageal Varices
2D-shear Wave Spleen Elastography in Clinically Significant Portal Hypertension and High-risk Varices
The primary objective of this study is to evaluate the role of spleen shear wave elastography (SWE-SSM) for ruling in and ruling out clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic…
- Trial name
- NCT07122622
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
TIPS, Portal Hypertension
TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease
Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal…
- Conditions
- TIPS, Portal Hypertension, Porto-Sinusoidal Vascular Disease, Refractory Ascite
- Trial name
- TIPS-PSVD (NCT07163689)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Liver Cirrhosis, Portal Hypertension
VICIS - Vienna Cirrhosis Study
Patients with advanced chronic liver diseases treated at the Vienna General Hospital of the Medical University of Vienna will be offered to participate in this prospective observational trial - including an optional participation…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Ascites, Variceal Hemorrhage
- Trial name
- VICIS (NCT03267615)
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Medical University of Vienna
Cirrhosis, Portal Hypertension Related to Cirrhosis
CARPEUS : Effect of Carvedilol on the Portosystemic Gradient as Measured by Endoscopic Ultrasound
The purpose of this study is to assess the efficacy after one month of treatment with Carvedilol (12.5 mg daily) in primary prophylaxis of digestive haemorrhage due to portal hypertension in cirrhosis, by endoscopic…
- Trial name
- CARPEUS (NCT06861075)
- Testing
- Carvedilol
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Decompensated Liver Cirrhosis
TIPS in Patients With Decompensated Liver Cirrhosis
This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School.
- Trial name
- NCT04801290
- Testing
- TIPS insertion
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Hannover Medical School
Portal Hypertension, Cirrhosis
Safety of Discontinuing NSBBs in Cirrhotic Patients With Managed Primary Aetiological Factors
This multicentre, prospective cohort study aims to enrol 375 patients with cirrhosis who meet the following criteria: 1. effective management or elimination of the primary aetiological factor (i.e., sustained virological response…
- Conditions
- Portal Hypertension, Cirrhosis, Varices, Esophageal
- Trial name
- NCT06549673
- Where
- 8 sites in Australia, China and 3 more
- Volunteers
- 375 people
- Sponsor
- Chinese University of Hong Kong
Liver Cirrhosis, Clinically Significant Portal Hypertension
Portal Inflow Modulation Prior to Liver Transplantation in Patients With Increased Risk of Intraoperative Blood Loss
Liver transplantation is a procedure associated with an exceptionally high risk of blood loss. Liver failure, which is the most common indication for transplantation, not only leads to coagulation disorders but also to the…
- Trial name
- PIMLivT (NCT07111221)
- Testing
- Transjugular Intrahepatic Portosystemic Shunt, Non-selective beta-blockers
- Where
- Poland
- Volunteers
- 104 people
- Sponsor
- Medical University of Warsaw
Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection
A Study to Predict Recompensation in Patients With Decompensated Cirrhosis Using Spleen Stiffness and Simple Blood Tests
The goal of this observational study is to learn if spleen stiffness and other non-invasive markers can help predict recompensation in people with decompensated cirrhosis who are receiving effective treatment for the cause of…
- Conditions
- Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Alcohol-Related Liver Disease
- Trial name
- LEAD-2 (NCT07087041)
- Where
- 28 sites in China
- Volunteers
- 735 people
- Sponsor
- Beijing Friendship Hospital
Acute Necrotizing Pancreatitis, Portal Hypertension
A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension
This study is a prospective, single-center, randomized controlled trial focusing on patients with acute necrotizing pancreatitis (ANP) complicated by pancreatic sinistral portal hypertension (PSPH).
- Trial name
- NCT07080697
- Testing
- Splenectomy, Control
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhejiang University
Portal Vein Thrombosis, Portal Hypertension Related to Cirrhosis
Endoscopic Ultrasound-guided Measurement of Portal Vein Pressure Gradient
This study aims to evaluate the accuracy and safety of a novel endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement technique in 42 adults with liver cirrhosis and portal vein thrombosis (blood clots in the…
- Trial name
- NCT07062289
- Testing
- endoscopic ultrasound-guided portal pressure gradient
- Volunteers
- 42 people
- Sponsor
- Zhejiang University
Liver Diseases, Liver Transplantation
Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific…
- Trial name
- LSM (NCT05339984)
- Testing
- Partial hepatectomy (open approach), liver transplantation, Portal vein embolization
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asymptomatic Cirrhosis, Clinically Significant Portal Hypertension
Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial
Decompensation of cirrhosis is a turning point in cirrhosis course, as associated with a marked decrease in life expectancy. Thus, prevention of decompensation is crucial.
- Trial name
- CARVECIR (NCT06263816)
- Testing
- Experimental group: Patients will be treated with carvedilol.
- Where
- 24 sites in France
- Volunteers
- 290 people
- Sponsor
- University Hospital, Tours
Cirrhosis, Liver, Splenectomy; Status
The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on Liver Reserve Function for Cirrhosis Patients
In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection.
- Conditions
- Cirrhosis, Liver, Splenectomy; Status, Portal Hypertension
- Trial name
- ELSDL (NCT05325437)
- Testing
- Laparoscopic splenectomy and azygoportal disconnection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Northern Jiangsu People's Hospital
End Stage Liver Disease, Jaundice
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury.
- Conditions
- End Stage Liver Disease, Jaundice, Liver Dysfunction, Portal Hypertension
- Trial name
- NCT06173947
- Testing
- FibroScan® Expert 630
- Where
- China
- Volunteers
- 411 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Portal Hypertension
Electromagnetic Positioning-Assisted Ultrasound Guidance in Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) is an important method for treating complications related to portal hypertension. The difficulty of its surgical procedures lies in portal vein puncture.
- Trial name
- NCT06979622
- Testing
- ultrasound combined with electromagnetic positioning guidance
- Volunteers
- 20 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Esophageal Varices, Portal Hypertension
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension.
- Trial name
- NCT06970509
- Where
- 10 sites in China
- Volunteers
- 1,450 people
- Sponsor
- Shanghai Zhongshan Hospital