Clinical trials: Positive Axillary Lymph Node
BREAST CANCER, PET/CT
68Ga FAPI PET/CT Evaluation of Axillary Lymph Node Status After Neoadjuvant Therapy in Patients With Clinical Axillary Lymph Node Positive Breast Cancer
The goal of this observational study is to learn whether 68Ga-FAPI PET/CT may be used as a new effective methods for evaluating axillary lymph node efficacy after neoadjuvant treatment for breast cancer.
- Trial name
- NCT06559371
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Kunwei Shen
Sentinel Lymph Node
SENTINEL LYMPH NODE BIOPSY AFTER NEOADJUVANT CHEMOTHERAPY
Omitting axilary lymph node dissection (ALND) following SLNB with residual cancer in patients with locally advanced disease after neoadjuvan chemotherapy (NAC) is still controversial.
- Trial name
- NEOSENTITURK (NCT04250129)
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Federation of Breast Diseases Societies
Breast Neoplasm, Neoadjuvant Therapy
RISAS Procedure in Node Positive Breast Cancer Following NAC
Chemotherapy in clinically node positive breast cancer patients is increasingly administrated in a neoadjuvant setting. The standard treatment regimen in these cases is then: neoadjuvant chemotherapy (NAC) followed by breast…
- Conditions
- Breast Neoplasm, Neoadjuvant Therapy, Axillary Lymph Nodes, Pathological Complete Response
- Trial name
- RISAS (NCT02800317)
- Testing
- RISAS
- Where
- 14 sites in Netherlands
- Volunteers
- 248 people
- Sponsor
- Erasmus Medical Center
Breast Cancer Female, Breast Cancer, Male
Vaccine to Prevent Recurrence in Patients With HER-2 Positive Breast Cancer
The main purpose of this study is to evaluate the safety of each study vaccine and to evaluate the effect on the time to disease recurrence (assessed by disease free survival).
- Conditions
- Breast Cancer Female, Breast Cancer, Male, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT03384914
- Testing
- DC1 Vaccine, WOKVAC Vaccine
- Where
- 7 sites in United States
- Volunteers
- 119 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Invasive Breast Cancer
Axillary Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node
Data from cohorts, prospective studies and one randomized trial (ASCOG Z0011) support the hypothesis that omission of additional axillary dissection in case of positive sentinel node has a limited impact on overall survival and…
- Trial name
- NCT01717131
- Testing
- Surgery for standard axillary node dissection, No axillary lymph node dissection
- Where
- France
- Volunteers
- 2,228 people
- Sponsor
- Institut Paoli-Calmettes
Breast Cancer
Hormone Therapy in Treating Postmenopausal Women With Receptor-Positive Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002646
- Testing
- fenretinide, tamoxifen citrate
- Where
- 85 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Eastern Cooperative Oncology Group
Breast Cancer
Lymph Node Identification Using Magtrace and Magseed Before Chemotherapy
Magnetic tracer injected before preoperative chemotherapy in breast cancer patients for sentinel lymph node detection. Also, magnetic tracer in combination with magnetic clip for index node identification.
- Trial name
- SentiNeo2 (NCT06104371)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 459 people
- Sponsor
- Vastra Gotaland Region
Breast Cancer
Role of Axillary Lymph Node Dissection for Residual MACROMETASTASES After NEOADJUVANT Chemotherapy in Patients With HER2+ and Triple Negative Breast Cancer: The OPBC-11/MACRONAC Study
In this multicenter retrospective cohort study the aim is to determine the safety of omission of axillary lymph node dissection in patients with TNBC and HER2+ tumors with residual macrometastases (in the SLN/TAD/TAS or MARI…
- Trial name
- MACRONAC (NCT07546695)
- Testing
- Data Collection from medical records of from an already existing database "ONCOLOGICAL BREAST SURGERY DATABASE OF THE UNIVERSITY HOSPITAL OF BASEL" which was initiated in 2016.
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer
Fluorouracil, Epirubicin, and Cyclophosphamide Alone or Followed by Paclitaxel for Early Breast Cancer
The efficacy of adjuvant chemotherapy is limited in patients with a high risk of recurrence. Also, for axillary positive node patients, optimum chemotherapy regimens are still under discussion.
- Trial name
- NCT00129922
- Testing
- paclitaxel, Fluorouracil, Epirubicin
- Where
- 64 sites in Spain
- Volunteers
- 1,289 people
- Sponsor
- Spanish Breast Cancer Research Group
Node-positive Breast Cancer
Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)
RATIONALE: The use of tailored axillary dissection as a tailored procedure will avoid surgical overtreatment by selectively removing the lymph nodes that are affected by the cancer, thereby sparing many women the unnecessary…
- Trial name
- TAXIS (NCT03513614)
- Testing
- Tailored axillary surgery - both Arms, Radiotherapy - Arm A, Radiotherapy - Arm B
- Where
- 64 sites in United States, Argentina and 11 more
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer
Axillary Nodal Burden in HER2+ and TNBC
This study aimed to evaluated rates of pathologic axillary nodal metastasis in patients with with early-stage HER2-positive BC or TNBC who had clinically node-negative status on preoperative ultrasonography and underwent upfront…
- Trial name
- NCT07211451
- Testing
- Breast conserving surgery with axillary surgery
- Where
- South Korea
- Volunteers
- 1,571 people
- Sponsor
- Gangnam Severance Hospital
Breast Cancer
S9927 Radiation Therapy After Surgery, Chemotherapy, and/or Hormone Therapy in Stage II Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether mastectomy, chemotherapy, and/or hormone therapy are more effective with or without radiation therapy in treating breast…
- Trial name
- NCT00005983
- Testing
- radiation therapy, surgery
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- SWOG Cancer Research Network
Stage II Breast Cancer, Stage IIIA Breast Cancer
Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy
This randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and…
- Trial name
- NCT01901094
- Testing
- Axillary Lymph Node Dissection (ALND), Nodal Radiation Therapy, Axillary Radiation Therapy
- Where
- 1,246 sites in United States, Canada and 1 more
- Volunteers
- 2,012 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
A Study of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy in Patients With HER2-Positive Breast Cancer Who Have Residual Tumor in the Breast or Axillary Lymph Nodes Following Preoperative Therapy (KATHERINE)
This 2-arm, randomized, open-label study will evaluate the efficacy and safety of trastuzumab emtansine versus trastuzumab as adjuvant therapy in patients with HER2-positive breast cancer who have residual tumor present in the…
- Trial name
- NCT01772472
- Testing
- trastuzumab, trastuzumab emtansine
- Where
- 268 sites in United States, Argentina and 26 more
- Volunteers
- 1,486 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer, Axilla; Breast
De-escalating Axillary Surgery in Breast Cancer Patients in Nigeria
In sub-Saharan Africa, breast cancer patients often present with advanced disease. In my previous research which evaluated over 600 patients from a prospective institutional data base, about 64% of women with a new diagnosis of…
- Trial name
- NCT06039956
- Testing
- Sentinel lymph Node Biopsy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Breast Carcinoma Metastatic in Lymph Node, HER2 Positive Breast Carcinoma
Validation of TAD in HER-2 with More Than 2 Lymph Nodes
The main objective of the study is to validate the DAT technique in patients with Her2-positive breast cancer who have more than two positive axillary lymph nodes at diagnosis.
- Trial name
- DAD-HER2 (NCT06821490)
- Testing
- Targeted axillary dissection and subsequently a lymphadenectomy
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Breast Cancer, Neoadjuvant Therapy
Minimal Invasive Axillary Staging and Treatment After Neoadjuvant Systemic Therapy in Node Positive Breast Cancer
Today, the majority of clinically node positive (cN+) breast cancer patients is treated with neoadjuvant systemic therapy (NST). Axillary staging and treatment after NST in cN+ patients are areas of controversy.
- Conditions
- Breast Cancer, Neoadjuvant Therapy, Lymph Node Metastases
- Trial name
- MINIMAX (NCT04486495)
- Where
- 35 sites in Netherlands
- Volunteers
- 549 people
- Sponsor
- Maastricht University Medical Center
Breast Cancer, Node-positive Breast Cancer
TAD in Primary Breast Cancer With Initially ≥ 3 Suspicious Lymph Nodes
Due to high pathological complete remission (pCR) rates in both breast and lymph nodes (ypT0/Tis, ypN0) following neoadjuvant systemic therapy (NST) in many patients with initially clinically node-positive (cN+) breast cancer…
- Trial name
- SenTa2 (NCT05462457)
- Testing
- Targeted axilllary dissection (TAD) followed by axillary lymph node dissection (ALND)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Kliniken Essen-Mitte
Breast Cancer
Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00881361
- Testing
- systemic chemotherapy, axillary lymph node dissection, neoadjuvant therapy
- Where
- 324 sites in United States
- Volunteers
- 756 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer, Sentinel Lymph Node
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
- Trial name
- ATNEC (NCT04109079)
- Testing
- Axillary lymph node dissection, Axillary radiotherapy, Breast or chest wall radiotherapy
- Where
- 98 sites in Ireland, United Kingdom
- Volunteers
- 1,900 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust