Clinical trials: Positive End-expiratory Pressure (PEEP)
ARDS (Acute Respiratory Distress Syndrome)
Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography
Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the…
- Trial name
- TICTAC (NCT07623590)
- Testing
- PEEP titrations
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Postoperative Complications, Respiratory Insufficiency
Optimal PEEP for Postoperative Oxygenation and Lung Aeration (ULTRASVENT-2)
The purpose of this multicenter, randomized controlled trial (ULTRASVENT-2) is to evaluate the effect of different positive end-expiratory pressure (PEEP) levels on postoperative oxygenation and lung aeration in adult patients…
- Conditions
- Postoperative Complications, Respiratory Insufficiency, Pulmonary Atelectasis, Positive-End Expiratory Pressure
- Trial name
- ULTRASVENT-2 (NCT07613177)
- Testing
- Intraoperative Positive End-Expiratory Pressure (PEEP) Regulation
- Where
- Russia
- Volunteers
- 360 people
- Sponsor
- Moscow Multidisciplinary Clinical Center "Kommunarka"
Anesthesia, Child
Effect of PEEP on Gastric Insufflation During Face Mask Induction of General Anesthesia in Children
The aim of our study is first to assess the effect of different PEEP levels on gastric volume using ultrasonography during induction of general anesthesia in children undergoing elective surgery
- Trial name
- NCT06127173
- Testing
- Positive End Expiratory Pressure PEEP
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Kasr El Aini Hospital
ARDS Due to Severe Acute Respiratory Syndrome Coronavirus 2
PEEP Setting in COVID19-related ARDS
The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate.
- Trial name
- NCT05115526
- Testing
- PEEP setting
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
Optic Nerve Sheath Diameter
Effect of Different Positive End-Expiratory Pressure (PEEP) Levels on Optic Nerve Sheath Diameter
The goal of this prospective observational study is to evaluate the effects of different PEEP values on the optic nerve sheath diameter (ONSD), a noninvasive indicator of intracranial pressure (ICP), in patients undergoing…
- Trial name
- NCT07085949
- Testing
- 5 cmH2O PEEP, 10 cmH2O PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Izmir City Hospital
General Anesthesia, Laparoscopic Cholecystectomy
Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity
It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position.
- Trial name
- NCT01267916
- Testing
- RR 6 + 0, RR 10 + 0, RR 16 + 0
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul Medical Center
Heart Rate Determination
Correlation Between Respiratory Variability of R-R Intervals and Systolic Pressure Variability
This prospective study is designed to assess and quantify the correlation between respiratory changes in R-R interval and the respiratory changed in invasive systolic blood pressure in ventilated patients during changes in…
- Trial name
- NCT03267017
- Testing
- posture changes
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Obesity
Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation.
- Trial name
- NCT02492113
- Testing
- Positive end-expiratory pressure (PEEP), ZEEP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Airway Management, Positive End Expiratory Pressure
Airway Effects of PEEP During Anesthesia Induction.
This study investigates airway effects of PEEP during maskventilation at anesthesia induction. Four patient groups will be ventilated with different PEEP and driving pressures to evaluate time to open airway after start of…
- Conditions
- Airway Management, Positive End Expiratory Pressure, Mask-ventilation, Anesthesia Induction
- Trial name
- NCT02920879
- Testing
- PEEP-level, driving pressure
- Volunteers
- 120 people
- Sponsor
- Region Örebro County
Robotic Thoracic Surgery, Mechanical Ventilation
Optimal Positive End-Expiratory Pressure in Robotic-Assisted Thoracic Surgery Without Capnothorax
The aim of this study is to assess the impact on lung mechanics during robotic lung resection when no capnothorax is used.
- Conditions
- Robotic Thoracic Surgery, Mechanical Ventilation, Positive End Expiratory Pressure (PEEP)
- Trial name
- NCT06784037
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
Respiratory Distress Syndrome, Adult
Pilot Study of Positive-End Expiratory Pressure in Acute Respiratory Distress Syndrome
Randomized controlled pilot trial in 70 patients with Acute Respiratory Distress Syndrome (ARDS) ventilated with low tidal volumes and limitation on airway pressure at 35 centimeters of water (cmH2O), to compare two different…
- Trial name
- PEEP-HUPA (NCT01119872)
- Testing
- Positive End-expiratory Pressure (PEEP)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Principe de Asturias
Respiratory Physiological Phenomena
Functional Residual Capacity Measured by Capnography in Ventilated Patients
Changes in body position during anesthesia can alter functional residual capacity and gas exchange. The monitoring of such changes in functional residual capacity is difficult at the bedside.
- Trial name
- NCT03693352
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Gynecologic Cancers
Alveolar Recruitment in Obese Patients in Major Gynaecological Cancer Surgery
In this study, the investigators planned to evaluate the effect of alveolar recruitment strategy primarily on postoperative pulmonary complications in obese patients undergoing lung protective ventilation in major open…
- Trial name
- NCT06619626
- Testing
- alveolar recruitment strategy applied group, group without alveolar recruitment strategy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Positive End Expiratory Pressure
Titration of Intraoperative PEEP in Patients Undergoing Robotic Assisted Laparoscopic Prostatectomy
Optimal intraoperative positive end expiratory pressure (PEEP) improves the outcome. Optimal PEEP is not only very different among individuals, but each individual's optimal PEEP is affected by positioning, muscle paralysis, and…
- Trial name
- TIPPR (NCT05155371)
- Testing
- Titration of Optimal Positive End-expiratory Pressure
- Where
- 2 sites in China
- Volunteers
- 95 people
- Sponsor
- Fudan University
Infant, Newborn, Infant, Low Birth Weight
Delivery Room CPAP in Extremely Low Birth Weight Infants
This pilot study was designed to determine the feasibility of randomizing extremely low birth weight (ELBW) infants <28 weeks' gestation who required resuscitation to one of two resuscitation methods, either: (a) 100% oxygen by…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- DR-CPAP (NCT01223274)
- Testing
- CPAP/PEEP, Standard management practices
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- NICHD Neonatal Research Network
Pediatric Anesthesia
PEEP During Induction of Anesthesia in Small Children
Positive end-expiratory pressure (PEEP) applied during induction of anesthesia prevents atelectasis formation and increases the duration of nonhypoxic apnea in obese and nonobese patients.
- Trial name
- NCT03540940
- Testing
- PEEP, ZEEP
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Transient Tachypnea of the Newborn
Positive End Expiratory Pressure With A T-piece Resuscitator For Near-Term and Term Infants With Respiratory Distress
Evaluating the effect of early application of Continuous positive airway pressure (CPAP) via Neopuff in cases of transient tachypnea of the newborn(TTN) and its role in decreasing the duration and complication of TTN.
- Trial name
- NCT01859533
- Testing
- Neopuff
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Bronchiectasis
Oscillating PEP vs Autogenic Drainage in People With Bronchiectasis
In this study, investigating two modes of chest physiotherapy on lung clearance index (LCI), 50 patients with bronchiectasis will be randomized to either oPEP or autogenic drainage.
- Trial name
- oPEP-vs-AD (NCT03013452)
- Testing
- oPEP, Autogenic drainage
- Where
- 2 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Carmel Medical Center
Acute Respiratory Distress Syndrome, ARDS
Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
Doctors follow a standard ventilator management strategy when making adjustments to the breathing machine to optimize the amount of oxygen into the lungs.
- Trial name
- NCT03793842
- Testing
- Usual care, PEEP titration by EIT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Michigan
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health