Clinical trials: Positive End-expiratory Pressure (PEEP)
Positive-Pressure Respiration/Methods, Esophagus/Physiopathology
Intraoperative PEEP Setting During Laparoscopic Gynecologic Surgery
The creation of pneumoperitoneum during laparoscopic surgery can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and…
- Conditions
- Positive-Pressure Respiration/Methods, Esophagus/Physiopathology, Pleura/Physiopathology, Gynecologic Surgical Procedures
- Trial name
- NCT03256396
- Testing
- PEEP setting based on esophageal pressure measured
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
Mechanical Ventilation
Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects of Changes in Ventilator Parameters on Breathing Pattern
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assist to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT00529347
- Testing
- neurally adjusted ventilatory assist (NAVA)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Respiratory Distress Syndrome
Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
- Trial name
- ELSE (NCT03281473)
- Testing
- Strategy 1, Strategy 2
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Acute Respiratory Distress Syndrome
PEEP Test and Gas Exchange in ALI/ARDS Patients
The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.
- Trial name
- NCT00284102
- Testing
- Mechanical ventilation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Policlinico Hospital
Atelectasis, Hypoxemia
Pulmonary Ultrasound for the Assessment of Atelectasis in Anesthetized Children Using a Laryngeal Mask Airway.
This study will use lung ultrasounds (LUS) to evaluate the incidence and severity of intraoperative atelectasis in anesthetized children undergoing minor surgery using a laryngeal mask airway.
- Trial name
- NCT06214312
- Testing
- Lung Ultrasounds
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Obesity, Intra-Abdominal Hypertension
Chest Wall Influence on Respiratory System Mechanics in Morbidly Obese Patients
The goal of this study is to describe the influence of the chest wall on the respiratory system mechanics in morbidly obese patients and in patients with high intra-abdominal pressure.
- Trial name
- NCT02105220
- Testing
- Respiratory mechanics assessment
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Mechanical Ventilation
Thoraco-abdominal Volume Variations During Anesthesia Studied by OEP.
The aim of this study is to examine chest wall volume changes monitored by opto-electronic plethysmography during recovery from anesthesia and early postoperative period.
- Trial name
- NCT01474850
- Testing
- lung recruitment maneuver
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Uppsala University Hospital
Respiratory Compliance
Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance Volume Profile in Children
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
- Trial name
- NCT04633720
- Testing
- Changes in positive end-expiratory pressure and tidal volume
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Pulmonary Atelectasis, Postoperative
Individual Optimal Positive End-expiratory Pressure During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted radical prostatectomy, pneumoperitoneum with Trendelenburg position is used. However, perioperative atelectasis and respiratory complications may occur with high incidence due to general anesthesia and…
- Trial name
- NCT04085146
- Testing
- Individualized optimal positive end-expiratory pressure, Conventional positive end-expiratory pressure
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Distress Syndrome (ARDS)
Assessment of the Reproducibility of the Recruitment-to-inflation Ratio (R/I Ratio) Measurement in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a severe lung condition that often requires invasive mechanical ventilation in the intensive care unit.
- Trial name
- RIRR (NCT07666503)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ultrasound Guided Recruitment Manauvere, End Expiratory Pressure
Ultrasound Guided Recruitment Manauvere Versus Individualized Positive End Expiratory Pressure in Pediatric Patients Undergoing Laparoscopic Abdominal Surgery
The aim of this prospective randomized controlled study is to compare the effect of US-guided Recruitment Manauvere (RM) versus individualized positive end-expiratory pressure (PEEP) on oxygenation and preventing respiratory…
- Conditions
- Ultrasound Guided Recruitment Manauvere, End Expiratory Pressure, Pediatric Patients, Laparoscopic Abdominal Surgery
- Trial name
- NCT06306820
- Testing
- Fixed PEEP, Ultrasound-guided lung recruitment, Individualized PEEP
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Cerebral Hemodynamics, Mechanical Ventilation Strategies
Cerebral Hemodynamic Effects of Individualized PEEP During Robotic Prostatectomy
This randomized clinical trial will compare two approaches to setting positive end-expiratory pressure (PEEP) during robot-assisted radical prostatectomy performed in the Trendelenburg position.
- Conditions
- Cerebral Hemodynamics, Mechanical Ventilation Strategies, Robotic Prostatectomy
- Trial name
- NCT07784010
- Testing
- Individualized PEEP Titration, Standard PEEP Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Postoperative Respiratory Complications
PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery
The purpose of this international, multicentre, double-blinded randomized controlled trial is to determine if the "open lung approach" providing recruitment maneuvers and PEEP(Positive End Expiratory Pressure) during general…
- Trial name
- PROVHILO (NCT01441791)
- Testing
- Lung protective strategy ventilation
- Where
- 30 sites in United States, Austria and 8 more
- Volunteers
- 900 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Robot-Assisted Radical Prostatectomy
Effect of Control Ventilation, PEEP, and PEEP With ARM in Robot-assisted Radical Prostatectomy
The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia.
- Trial name
- NCT07462689
- Testing
- PEEP group, PEEP + ARM group
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ilsan Cha hospital
One Lung Ventilation
Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation
Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial…
- Trial name
- NCT01652612
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- Yonsei University
Anesthesia, Surgery
The Effects of Individualized Lung-protective Ventilation With Lung Dynamic Compliance-guided Positive End-expiratory Pressure(PEEP) Titration on Postoperative Pulmonary Complications of Pediatric Video-assisted Thoracoscopic Surgery
This study evaluates the influence of individualized lung-protective ventilation strategy(LPVS) on postoperative pulmonary complications(PPCs) through a randomized controlled trial when children undergoing thoracoscopic surgery…
- Trial name
- PEEP (NCT05386901)
- Testing
- Conventional positive end-expiratory pressure(PEEP), Lung dynamic compliance guided positive end-expiratory pressure(PEEP)
- Where
- China
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Jiaxiang Chen
Atelectasis, Oxygenation
Zero Positive End-expiratory Pressure Before Emergence Prevents Postoperative Atelectasis.
A study on healthy patients undergoing anesthesia for non-abdominal surgery - evaluation of positive end-expiratory pressure versus zero positive end-expiratory pressure on the amount of atelectasis in the early postoperative…
- Trial name
- NCT03351946
- Testing
- ZEEP, PEEP
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Västmanland
Pediatric Surgery
Determination of Best PEEP (Positive End-expiratory Pressure) in Anesthetized Infants in Terms of Prevention of Atelectasis
Purpose of research; to determine the appropriate positive end-expiratory pressure to minimize atelectasis during general anesthesia in infants.
- Trial name
- NCT03969173
- Testing
- applying PEEP3, applying PEEP6, applying PEEP9
- Where
- South Korea
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Craniotomy Surgery, Pediatric Patient Safety
The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position
This study evaluated the effect of positive end-expiratory pressure (PEEP) on optic nerve sheath diameter (ONSD), an indicator of intracranial pressure, in pediatric patients undergoing craniotomy in the supine position.
- Conditions
- Craniotomy Surgery, Pediatric Patient Safety, Pediatric Patient, Positive End-expiratory Pressure (PEEP)
- Trial name
- NCT07370779
- Testing
- General Anesthesia, Anesthetic Agents, mechanical ventilation (MV)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Cardiac Arrest, Out-Of-Hospital
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
The goal of this clinical trial is to learn if applying positive end-expiratory pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves neurological outcome in adults with out-of-hospital cardiac arrest who receive an…
- Trial name
- REVIVE-PEEP (NCT07905482)
- Testing
- Fixed PEEP Valve
- Where
- 3 sites in Netherlands
- Volunteers
- 3,200 people
- Sponsor
- Jeroen van Eijk